Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 21, 2024
Neutrophil
extracellular
traps
(NETs)
formed
by
neutrophils
are
netlike
scaffolds
that
mainly
contain
DNA
and
a
variety
of
granule
proteins.
Many
stimuli
can
lead
to
the
NET
formation
through
independent
molecular
pathways.
Clinically,
abundance
NETs
is
correlated
with
poor
tumor
prognosis.
The
biological
actions
complex
diverse,
including
promoting
progression,
awakening
dormant
cancer
cells,
resulting
in
immunosuppression
support
growth
metastasis.
Therefore,
NET‐associated
pathological
processes
provide
an
important
clue
for
both
diagnostic
imaging
alternative
therapies
many
kinds
cancers.
In
recent
years,
scientists’
efforts
have
focused
on
developing
novel
probes
visualize
therapeutic
strategies
degrading
or
inhibiting
its
block
their
pro‐tumoral
functions.
this
review,
development
evaluation
NETs‐targeted
intervention
progress
therapy
on.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
Abstract
Functional
biomaterials
composed
of
multiple
biomacromolecules
have
significant
advantages
over
those
made
from
a
single
type.
However,
harmoniously
integrating
various
remains
challenging.
Neutrophil
extracellular
traps
(NETs),
an
emerging
biological
structure
released
neutrophils,
serve
as
natural
prototype
worth
investigating
and
learning
from.
NETs
consist
intricate
exhibit
web‐like
microstructure,
endowing
them
with
multifaceted
roles
in
both
physiological
pathological
processes.
In
this
review,
research
progress
is
systematically
examined
on
materials
science
perspective.
First,
the
origin
transformation
are
introduced,
their
functional
mechanisms
NET
components
thoroughly
dissected
rather
than
conventionally
treating
entity.
Second,
given
complex
functions,
revealed
potential
biomarker
for
disease
prediction.
Third,
typical
characterization
technologies
analysis
summarized.
Fourth,
artificial
inspired
by
discussed.
addition,
regulatory
processes
provide
bio‐inspired
prototypes
design
advanced
materials.
Finally,
perspectives
opportunities
challenges
advancing
presented
biomarkers
models
development
Cancer Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 29, 2025
Abstract
Neutrophils
are
important
components
of
the
immune
system
and
play
a
key
role
in
defending
against
pathogenic
infections
responding
to
inflammatory
cues,
including
cancer.
Their
dysregulation
indicates
potential
disease
risk
factors.
However,
their
functional
importance
progression
has
often
been
underestimated
due
short
half‐life,
especially
as
there
is
limited
information
on
intratumoral
neutrophils.
Recent
studies
prominent
cancer
have
led
paradigm
shift
our
understanding
diversity
These
highlight
that
neutrophils
emerged
tumor
microenvironment,
where
they
can
dual
promoting
suppressing
Moreover,
several
approaches
therapeutically
target
emerged,
clinical
trials
investigating
efficacy.
In
this
review,
we
discussed
involvement
initiation
progression.
We
summarized
recent
advances
therapeutic
strategies
targeting
and,
most
importantly,
suggested
future
research
directions
could
facilitate
manipulation
for
purposes
patients.
Biology Direct,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 11, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
as
well
leading
causes
mortality
worldwide,
and
sorafenib
first-line
treatment
in
HCC
patients.
Unfortunately,
drug
resistance
to
often
develops.
However,
underlying
mechanism
remains
unclear.
Here,
we
reveal
important
role
macrophage
extracellular
traps
(METs)-mediated
crosstalk
between
macrophages
tumor
cells
resistance.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Immune
cells
show
enormous
potential
for
targeted
nanoparticle
delivery
due
to
their
intrinsic
tumor-homing
skills.
However,
the
immune
can
internalize
nanoparticles,
leading
cellular
functional
impairments,
degradation
of
and
delayed
release
drugs
from
cells.
To
address
these
issues,
this
study
introduces
an
approach
synthesis
freshly
derived
neutrophils
(NUs)-based
nanocarriers
system
where
NUs
are
surfaced
by
dialdehyde
alginate-coated
self-assembled
micelles
loaded
with
mitoxantrone
(MIT)
indocyanine
green
(ICG)
(i.e.,
dA(MI@IPM)s)
stimuli-responsive
tumor-targeted
therapy.
Here,
dA(MI@IPM)s
not
internalized
NUs,
but
they
anchored
on
membrane
via
distearoylphosphatidylethanolamine-polyethylene
glycol-polyethylenimine
anchors.
Owing
natural
recruitment
ability
tumor
microenvironment,
NUs-anchored
accumulation
is
higher
at
site
than
free
dA(MI@IPM)s,
readily
detach
get
in
The
disassembles
inside
cancer
upon
near-infrared
irradiation
photosensitizing
effect
ICG,
releasing
MIT
significantly
inhibiting
growth.
This
simple
fast
prepare,
opening
up
exciting
possibilities
personalized
treatment
using
patient's
autologous
NUs.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 28, 2025
Neutrophils,
the
most
abundant
myeloid
cells
in
human
peripheral
blood,
serve
as
first
defense
line
against
infection
and
are
also
significantly
involved
initiation
progression
of
cancer.
In
colorectal
cancer
(CRC),
neutrophils
exhibit
a
dual
function
by
promoting
tumor
events
exerting
antitumor
activity,
which
is
related
to
heterogeneity
neutrophils.
The
neutrophil
extracellular
traps
(NETs),
gut
microbiota,
various
within
microenvironment
(TME)
shaping
heterogeneous
This
article
provides
an
updated
overview
complex
functions
underlying
mechanisms
CRC
their
pivotal
role
guiding
prognosis
assessment
therapeutic
strategies,
aiming
offer
novel
insights
into
neutrophil-associated
treatment
approaches
for
CRC.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 6, 2025
Cancer-associated
myeloid
cells
due
to
their
plasticity
play
dual
roles
in
both
promoting
and
inhibiting
tumor
progression.
Myeloid
with
immunosuppressive
properties
a
critical
role
anti-cancer
immune
regulation.
Cells
of
different
origin,
such
as
associated
macrophages
(TAMs),
neutrophils
(TANs),
derived
suppressor
(also
called
MDSCs)
eosinophils
are
often
expanded
cancer
patients
significantly
influence
survival,
but
also
the
outcome
therapies.
For
this
reason,
variety
preclinical
clinical
studies
modulate
activity
these
have
been
conducted,
however
without
successful
date.
In
review,
pro-tumor
cells,
cell-specific
therapeutic
targets,
vivo
on
cell
re-polarization
impact
immunotherapies/genetic
engineering
addressed.
This
paper
summarizes
ongoing
trials
concept
chimeric
antigen
receptor
macrophage
(CAR-M)
therapies,
suggests
future
research
perspectives,
offering
new
opportunities
development
novel
treatment
strategies.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 10, 2025
Tumor
metabolic
reprogramming
is
a
highly
complex
process
that
enables
tumor
survival
in
the
presence
of
limited
nutrients,
involving
multiple
signaling
pathways,
non-coding
RNAs
(ncRNAs),
and
transcription
factors.
Lately,
glutamine
has
been
found
to
enhance
growth,
spread,
drug
resistance
cancer
cells,
while
also
fostering
an
immunosuppressive
microenvironment
aids
development.
However,
some
tumors,
such
as
pancreatic
melanoma,
additional
can
inhibit
proliferation
this
mechanism
closely
related
regulation
immune
microenvironment.
Therefore,
further
exploration
metabolism
tumors
essential
for
understanding
pathogenesis
developing
new
metabolically
targeted
therapies.
We
systematically
review
latest
research
on
its
role
system
regulation.
Additionally,
we
clinical
progress
therapies
their
application
combination
with
current
anti-tumor
treatments.
Ultimately,
address
challenges
prospects
involved
anti-cancer
strategies
aimed
at
metabolism.
