Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41536 - e41536

Published: Feb. 14, 2025

The gut-disc axis, which refers to the interaction between gut microbiota and bone health, has recently garnered widespread attention in scientific community. However, it remains be determined whether directly induces cervical spondylosis (CS). This study employed a bidirectional 2-sample Mendelian randomization (MR) analysis explore potential causal link CS. We initially used inverse variance weighted method for preliminary estimation supplemented with other MR methods, including MR-Egger, median, mode, simple mode. Furthermore, we utilized Cochrane Q test, MR-PRESSO global MR-Egger intercept test assess possible pleiotropy heterogeneity. Ultimately, conducted investigate reverse associations identified 27 significantly associated CS, of 12 may contributing factors, while 15 have protective effects. further revealed relationship CS 24 microbiota. In this study, no significant heterogeneity or was detected. Through analysis, uncovered providing new perspectives prevention treatment especially modulation

Language: Английский

Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 20, 2025

Cardiovascular disease (CVD) is the leading cause of death worldwide, with physical inactivity being a known contributor to global rates CVD incidence. incidence, however, not uniform recognized sex differences as well and racial ethnic differences. Furthermore, gut microbiota have been associated CVD, sex, race/ethnicity. Researchers begun examine interplay these complicated yet interrelated topics. This review will present evidence that (risk development), are distinct between sexes racial/ethnic groups, which appear be influenced by acculturation, discrimination, stress, lifestyle factors like exercise. this address beneficial impacts exercise on cardiovascular system provide recommendations for future research in field.

Language: Английский

Gut microbiota and osteonecrosis: A Mendelian randomization study

Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41703 - e41703

Published: March 7, 2025

Emerging evidence indicates an association between the gut microbiota and incidence of osteonecrosis (ON), yet literature has not adequately addressed whether this relationship is causal. This study uses data from MiBioGen Consortium UK Biobank for Mendelian randomization (MR) analysis to identify pathogenic microbial taxa associated with ON. Sensitivity analyses confirmed causal relationships, while reverse MR ruled out causation. SNP annotation located genetic variants linked instrumental variables in The inverse variance weighted method revealed 5 a ON, including order Erysipelotrichales (OR = 2.24, 95% CI 1.16-4.32, P .02), genus Christensenellaceae R 0.41, 0.19-0.87, family Erysipelotrichaceae Family XIII 0.45, 0.21-0.95, .04), class Erysipelotrichia .02). mitigated concerns regarding heterogeneity, directional pleiotropy, outliers (P > .05). However, showed no effect ON on these taxa. (single-nucleotide polymorphism) pinpointed 20 host genes pathogenesis. These findings lay groundwork microbiota-targeted therapies deepen our understanding gut-bone axis osteonecrosis.

Language: Английский