The Involvement and Manifestations of SARS-CoV-2 Virus in Cardiovascular Pathology DOI Creative Commons

Sofia Teodora Hărșan,

Anca Sin

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 773 - 773

Published: April 22, 2025

Although the acute phase of COVID-19 pandemic has subsided, emergence post-COVID-19 condition presents a new and complex public health challenge, characterized by persistent, multisystem symptoms that can endure for weeks or months after initial infection with SARS-CoV-2 virus, significantly affecting survivors’ quality life. Among most concerning sequelae are cardiovascular complications, which encompass broad spectrum conditions, including arrhythmias, myocardial damage, postural orthostatic tachycardia syndrome. This narrative review explores burden on reviewing latest relevant findings in literature highlighting different aspects COVID-19’s involvement. investigates pathophysiological mechanisms underlying involvement condition, focus direct viral invasion via ACE2 receptors, immune-mediated injury, cytokine storm, systemic inflammation, endothelial dysfunction, mitochondrial injury. The interplay between pre-existing diseases, such as hypertension, atherosclerosis, diabetes, atrial fibrillation, is also explored, revealing individuals conditions at heightened risk both severe illness long-term complications. Long-term immune activation persistence antigens increasingly recognized contributors to ongoing even mild asymptomatic infections. As healthcare system continues adapt consequences pandemic, deeper understanding these manifestations essential. knowledge will inform development targeted strategies prevention, clinical management, rehabilitation affected patients. Furthermore, insights gained from intersection be instrumental shaping responses future epidemics, necessity multidisciplinary approaches patient care preparedness.

Language: Английский

Unlocking the potential of in silico approach in designing antibodies against SARS-CoV-2 DOI Creative Commons

Tasshitra R. Subramaniam,

Siti Aisyah Mualif, Weng Howe Chan

et al.

Frontiers in Bioinformatics, Journal Year: 2025, Volume and Issue: 5

Published: Feb. 13, 2025

Antibodies are naturally produced safeguarding proteins that the immune system generates to fight against invasive invaders. For centuries, they have been artificially and utilized eradicate various infectious diseases. Given ongoing threat posed by COVID-19 pandemics worldwide, antibodies become one of most promising treatments prevent infection save millions lives. Currently, in silico techniques provide an innovative approach for developing antibodies, which significantly impacts formulation antibodies. These develop with great specificity potency diseases such as SARS-CoV-2 using computational tools algorithms. Conventional methods designing frequently costly time-consuming. However, offers a contemporary, effective, economical paradigm creating next-generation especially accordance recent developments bioinformatics. By utilizing multiple antibody databases high-throughput approaches, unique construct can be designed , facilitating accurate, reliable, secure development human use. Compared their traditionally developed equivalents, large number -designed advanced swiftly clinical trials became accessible sooner. This article helps researchers more quickly affordably giving them access current information on approaches creation.

Language: Английский

Citations

0
The Involvement and Manifestations of SARS-CoV-2 Virus in Cardiovascular Pathology DOI Creative Commons

Sofia Teodora Hărșan,

Anca Sin

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 773 - 773

Published: April 22, 2025

Although the acute phase of COVID-19 pandemic has subsided, emergence post-COVID-19 condition presents a new and complex public health challenge, characterized by persistent, multisystem symptoms that can endure for weeks or months after initial infection with SARS-CoV-2 virus, significantly affecting survivors’ quality life. Among most concerning sequelae are cardiovascular complications, which encompass broad spectrum conditions, including arrhythmias, myocardial damage, postural orthostatic tachycardia syndrome. This narrative review explores burden on reviewing latest relevant findings in literature highlighting different aspects COVID-19’s involvement. investigates pathophysiological mechanisms underlying involvement condition, focus direct viral invasion via ACE2 receptors, immune-mediated injury, cytokine storm, systemic inflammation, endothelial dysfunction, mitochondrial injury. The interplay between pre-existing diseases, such as hypertension, atherosclerosis, diabetes, atrial fibrillation, is also explored, revealing individuals conditions at heightened risk both severe illness long-term complications. Long-term immune activation persistence antigens increasingly recognized contributors to ongoing even mild asymptomatic infections. As healthcare system continues adapt consequences pandemic, deeper understanding these manifestations essential. knowledge will inform development targeted strategies prevention, clinical management, rehabilitation affected patients. Furthermore, insights gained from intersection be instrumental shaping responses future epidemics, necessity multidisciplinary approaches patient care preparedness.

Language: Английский

Citations

0