Cardiac Fibroblasts: Helping or Hurting DOI Open Access
Mohammad Shameem,

Steve Olson,

Ezequiel Marrón Fernández de Velasco

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 381 - 381

Published: March 27, 2025

Cardiac fibroblasts (CFs) are the essential cell type for heart morphogenesis and homeostasis. In addition to maintaining structural integrity of tissue, muscle involved in complex signaling cascades that regulate cardiomyocyte proliferation, migration, maturation. While CFs serve as primary source extracellular matrix proteins (ECM), tissue repair, paracrine signaling, they also responsible adverse pathological changes associated with cardiovascular disease. Following activation, produce excessive ECM components ultimately lead fibrosis cardiac dysfunction. Decades research have led a much deeper understanding role cardiogenesis. Recent studies using single-cell genomic approach focused on advancing cellular interactions, mechanistic implications during development Arguably, unique development, disease progression categorizes them into friend or foe category. This brief review summarizes current fibroblast biology discusses key findings context pathophysiological conditions.

Language: Английский

Ubiquitin-specific protease: an emerging key player in cardiomyopathy DOI Creative Commons
Danlei Li, Qilin Ma

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 18, 2025

Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend accumulate under pathological conditions. Ubiquitin-specific protease (USP) is the largest deubiquitinating enzyme family and key component of ubiquitin proteasome system (UPS), non-lysosomal protein degradation machinery mediate PQC cells. USPs regulate stability activity target proteins that involve intracellular signaling, transcriptional inflammation, antioxidation, cell growth. Recent studies demonstrate can fibrosis, lipid metabolism, glucose homeostasis, hypertrophic response, post-ischemic recovery death such apoptosis ferroptosis cardiomyocytes. Since myocardial loss an important cardiomyopathy, therefore, these findings suggest UPSs play emerging roles cardiomyopathy. This review briefly summarizes recent literature on regulatory occurrence development giving us new insights into molecular mechanisms different cardiomyopathy potential preventive strategies for

Language: Английский

Citations

0
Cardiac Fibroblasts: Helping or Hurting DOI Open Access
Mohammad Shameem,

Steve Olson,

Ezequiel Marrón Fernández de Velasco

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 381 - 381

Published: March 27, 2025

Cardiac fibroblasts (CFs) are the essential cell type for heart morphogenesis and homeostasis. In addition to maintaining structural integrity of tissue, muscle involved in complex signaling cascades that regulate cardiomyocyte proliferation, migration, maturation. While CFs serve as primary source extracellular matrix proteins (ECM), tissue repair, paracrine signaling, they also responsible adverse pathological changes associated with cardiovascular disease. Following activation, produce excessive ECM components ultimately lead fibrosis cardiac dysfunction. Decades research have led a much deeper understanding role cardiogenesis. Recent studies using single-cell genomic approach focused on advancing cellular interactions, mechanistic implications during development Arguably, unique development, disease progression categorizes them into friend or foe category. This brief review summarizes current fibroblast biology discusses key findings context pathophysiological conditions.

Language: Английский

Citations

0