Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(3)

Published: Feb. 2, 2025

The precise mechanisms of blood pressure (BP) regulation are not fully elucidated, and understanding BP is crucial for managing hypertension improving outcomes cardiovascular disease. In this issue the JCI, Wang et al. identified transcription factor PR domain-containing protein 16 (PRDM16) as a regulator both vascular smooth muscle cell contraction circadian response to control. PRDM16 directly transcriptionally controlled expression adrenergic receptor α 1d several clock genes regulation. These findings identify mechanism how molecular pathways govern variation, highlighting potential target hypertension.

Language: Английский

Factors associated with blood pressure regulation in vascular smooth muscle cells

Hypertension Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Language: Английский