Mucins and Their Roles in Asthma DOI
Qihua Ye,

Gilda Opoku,

Marika Orlov

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: April 30, 2025

ABSTRACT Mucus is a crucial component of airway host defense. For optimal protection, its chief components—the mucins MUC5AC and MUC5B—need to be tightly regulated. Their expression localizes specific secretory epithelial cell types capable producing secreting massive glycopolymers. In asthma, abnormal mucus an important clinical problem that effectively treated with therapies directly target mucins. This review summarizes what known about how mucin gene regulation, protein synthesis, secretion are regulated in healthy asthmatic lungs. Ultimately, better understanding these processes could help identify novel ways preventing or reversing dysfunction.

Language: Английский

Mucins and Their Roles in Asthma DOI
Qihua Ye,

Gilda Opoku,

Marika Orlov

et al.

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: April 30, 2025

ABSTRACT Mucus is a crucial component of airway host defense. For optimal protection, its chief components—the mucins MUC5AC and MUC5B—need to be tightly regulated. Their expression localizes specific secretory epithelial cell types capable producing secreting massive glycopolymers. In asthma, abnormal mucus an important clinical problem that effectively treated with therapies directly target mucins. This review summarizes what known about how mucin gene regulation, protein synthesis, secretion are regulated in healthy asthmatic lungs. Ultimately, better understanding these processes could help identify novel ways preventing or reversing dysfunction.

Language: Английский

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