Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature

Diabetes and Vascular Disease Research, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 1, 2021

Type 2 diabetes mellitus is a pathology of heterogeneous etiology characterized by hyperglycemia resulting from lack insulin action, secretion, or both, and the population with predicted to be about 439 million worldwide 2030. Prolong has been related microvascular complications especially diabetic nephropathy. DN most common complication type mellitus, it leading cause end-stage renal disease worldwide. It crucial diagnose patients who are more sensible develop for better control process disease. Several factors mechanisms contribute development outcome Microalbuminuria an early marker use as routine screening, but damages may happening even without microalbuminuria. There several significant kidney damage biomarkers which helps in detection DN. An biomarker allow earlier diagnosis, treatment reduces prevalence slows progression. Therefore, this review focuses on laboratory that earlier, validation specific could potentially make possible treatment, retardation progression

Language: Английский

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Pro-resolving lipid mediators: regulators of inflammation, metabolism and kidney function

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 17(11), P. 725 - 739

Published: July 19, 2021

Language: Английский

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p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease

Journal of Clinical Investigation, Journal Year: 2020, Volume and Issue: 130(9), P. 5011 - 5026

Published: Aug. 16, 2020

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that was inhibited DKD models human kidneys. Ablation autophagy-related gene 7 (Atg7) from proximal tubules led to deficiency worse renal hypertrophy, tubular damage, inflammation, fibrosis, albuminuria mice, indicating a protective DKD. Autophagy impairment associated with downregulation unc-51-like autophagy-activating kinase 1 (ULK1), which mediated by upregulation microRNA-214 (miR-214) cells tissues. miR-214 prevented decrease ULK1 expression kidneys, resulting less hypertrophy albuminuria. Furthermore, blockade p53 attenuated induction DKD, leading higher levels autophagy, accompanied an amelioration Compared nondiabetic samples, biopsies patients diabetes showed miR-214, autophagy. found positive correlation between p53/miR-214 negative ULK1/LC3 fibrosis diabetes. Together, these results identify p53/miR-214/ULK1 axis pinpointing possible therapeutic targets for

Language: Английский

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Probiotics, prebiotics, and postbiotics in health and disease

MedComm, Journal Year: 2023, Volume and Issue: 4(6)

Published: Nov. 4, 2023

The gut microbiota and its homeostasis play a crucial role in human health. However, for some diseases related to the microbiota, current traditional medicines can only relieve symptoms, it is difficult solve root causes or even cause side effects like disturbances microbiota. Increasing clinical studies evidences have demonstrated that probiotics, prebiotics, postbiotics prevent treat various diseases, but currently they be used as dietary supplements rather than medicines, which restricts application of probiotics field medicine. Here, this review analyzes importance health problems systematically summarizes effectiveness mechanisms maintaining treating based on animal models trials. And research outcomes development trends field, challenges prospects their health, alleviating are analyzed. It hoped promote disease treatment open up new frontiers probiotic research.

Language: Английский

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AGE/RAGE in diabetic kidney disease and ageing kidney

Free Radical Biology and Medicine, Journal Year: 2021, Volume and Issue: 171, P. 260 - 271

Published: May 18, 2021

Language: Английский

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