COVID-19 vaccines in patients with cancer: immunogenicity, efficacy and safety

Nature Reviews Clinical Oncology, Journal Year: 2022, Volume and Issue: 19(6), P. 385 - 401

Published: March 11, 2022

Language: Английский

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Disproportionate Impact of COVID-19 on Racial and Ethnic Minority Groups in the United States: a 2021 Update

Journal of Racial and Ethnic Health Disparities, Journal Year: 2021, Volume and Issue: 9(6), P. 2334 - 2339

Published: Oct. 13, 2021

Language: Английский

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The effect of mandatory COVID-19 certificates on vaccine uptake: synthetic-control modelling of six countries

The Lancet Public Health, Journal Year: 2021, Volume and Issue: 7(1), P. e15 - e22

Published: Dec. 13, 2021

Mandatory COVID-19 certification (showing vaccination, recent negative test, or proof of recovery) has been introduced in some countries. We aimed to investigate the effect on vaccine uptake.We designed a synthetic control model comparing six countries (Denmark, Israel, Italy, France, Germany, and Switzerland) that (April-August, 2021), with 19 Using daily data cases, deaths, vaccinations, country-specific information, we produced counterfactual trend estimating what might have happened similar circumstances if certificates were not introduced. The main outcome was doses.COVID-19 led increased vaccinations 20 days before implementation anticipation, lasting up 40 after. Countries pre-intervention uptake below average had more pronounced increase compared those where already higher. In doses exceeded 55 672 (95% CI 49 668-73 707) vaccines per million population or, absolute terms, 3 761 440 (3 355 761-4 979 952) mandatory 72 151 (37 940-114 140) after (4 874 857 [2 563 396-7 711 769] doses). found no (Germany), an unclear when during period limited supply (Denmark). Increase highest for people younger than 30 years introduction certification. Access restrictions linked certain settings (nightclubs events >1000 people) associated years. When extended broader settings, remained high youngest group, but increases also observed aged 30-49 years.Mandatory could uptake, interpretation transferability findings need be considered context pre-existing levels hesitancy, eligibility changes, pandemic trajectory.Leverhulme Trust European Research Council.

Language: Английский

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Vaccine Hesitancy: Obstacles and Challenges

Current Pediatrics Reports, Journal Year: 2022, Volume and Issue: 10(4), P. 241 - 248

Published: Oct. 8, 2022

Language: Английский

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Factors affecting COVID-19 vaccine hesitancy among healthcare providers in 23 countries

Vaccine, Journal Year: 2022, Volume and Issue: 40(31), P. 4081 - 4089

Published: May 5, 2022

Several early COVID-19 studies aimed to assess the potential acceptance of a vaccine among healthcare providers, but relatively few this population have been published since vaccines became widely available. Vaccine safety, speed development, and low perceived disease risk were commonly cited as factors for hesitancy group. In secondary analysis based on cross-sectional, structured survey, authors associations between self-reported number sociodemographic perception using data from 3,295 providers (physicians, nurses, community health workers, other providers) in 23 countries. 494 (15.0%) participants reported hesitancy, whom 132 (4.0%) would outright refuse accept vaccine. Physicians least hesitant. was more likely occur those with less than median income and, lesser degree, younger age. Safety concerns lack trust that be equitably distributed strongly associated so about efficacy vaccines. Findings suggest need address safety through tailored messaging, training, and/or incentive approaches well international national vaccination efforts ensure equitable distribution.

Language: Английский

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Racial differences in institutional trust and COVID-19 vaccine hesitancy and refusal

BMC Public Health, Journal Year: 2021, Volume and Issue: 21(1)

Published: Nov. 16, 2021

Abstract Background Previous research has indicated that demographic differences affect COVID-19 vaccination rates. Trust, in both the vaccine itself and institutional trust, is one possible factor. The present study examines racial trust status among a nationally representative sample of adults United States. Methods Data for current was collected as part Wave 8 Omnibus 2000 survey conducted by RAND ALP consisted 2080 participants. Responses were through online March 2021. Results Trust scientific community strongest predictor already receiving at least dose time study. Asians had significantly higher compared to all other groups. also showed significant difference level government’s response pandemic with Indian/Alaskan Natives reporting lower Whites, Blacks Asians. when those who identified Other. Those identify American lowest levels trust. not indicative within sample. Conclusions Strategies increase can be employed address hesitancy community-based initiatives building partnerships between local stakeholders.

Language: Английский

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Correlates of COVID-19 Vaccine Hesitancy among a Community Sample of African Americans Living in the Southern United States

Vaccines, Journal Year: 2021, Volume and Issue: 9(8), P. 879 - 879

Published: Aug. 8, 2021

In the United States, African Americans (AAs) have been disproportionately affected by COVID-19 mortality. However, AAs are more likely to be hesitant in receiving vaccinations when compared non-Hispanic Whites. We examined factors associated with vaccine hesitancy among a predominant AA community sample. performed cross-sectional analysis on data collected from convenience sample of 257 community-dwelling participants Central Savannah River Area 5 December 2020, through 17 April 2021. Vaccine was categorized as resistant, hesitant, and acceptant. estimated relative odds resistance using polytomous logistic regression models. Nearly one-third were either (n = 40, 15.6%) or resistant 42, 16.3%) vaccination. Vaccine-resistant younger experienced housing insecurity due both acceptant participants, respectively. Age accounted for nearly 25% variation resistance, 21-fold increased (OR: 21.93, 95% CI: 8.97-5.26-91.43) aged 18 29 50 older adults. Housing 8% 7-fold (AOR: 7.35, 1.99-27.10). this sample, under age 30 those experiencing because pandemic free

Language: Английский

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Attitudes towards vaccines and intention to vaccinate against COVID-19: a cross-sectional analysis—implications for public health communications in Australia

BMJ Open, Journal Year: 2022, Volume and Issue: 12(1), P. e057127 - e057127

Published: Jan. 1, 2022

Objective To examine SARS-CoV-2 vaccine confidence, attitudes and intentions in Australian adults as part of the iCARE Study. Design setting Cross-sectional online survey conducted when free COVID-19 vaccinations first became available Australia February 2021. Participants Total 1166 Australians from general population aged 18–90 years (mean 52, SD 19). Main outcome measures Primary outcome: responses to question ‘If a for were today, what is likelihood that you would get vaccinated?’. Secondary analyses putative drivers uptake, including socioeconomic status sources trust, derived multiple questions. Results Seventy-eight per cent reported being likely receive vaccine. Higher associated with: increasing age (OR: 2.01 (95% CI 1.77 2.77)), male (1.37 1.08 1.72)), residing least disadvantaged area quintile (2.27 1.53 3.37)) self-perceived high risk getting (1.52 2.14)). However, 72% did not believe they at COVID-19. Findings regarding vaccines similar except there no sex differences. For both general, differences vaccinate function education level, perceived income level rurality. Knowing safe effective vaccinated will protect others, trusting company made it vaccination recommended by doctor influence large proportion study cohort uptake intent continue engaging virus-protecting behaviours (mask wearing, social distancing, etc) postvaccine. Conclusions Most are Key influencing factors identified (eg, knowing effective, doctor’s recommendation vaccinated) can inform public health messaging enhance rates.

Language: Английский

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Coronavirus Disease 2019 (COVID-19) Pandemic across Africa: Current Status of Vaccinations and Implications for the Future

Vaccines, Journal Year: 2022, Volume and Issue: 10(9), P. 1553 - 1553

Published: Sept. 17, 2022

The introduction of effective vaccines in December 2020 marked a significant step forward the global response to COVID-19. Given concerns with access, acceptability, and hesitancy across Africa, there is need describe current status vaccine uptake continent. An exploratory study was undertaken investigate these aspects, challenges, lessons learnt Africa provide future direction. Senior personnel 14 African countries completed self-administered questionnaire, descriptive analysis data. Vaccine roll-out commenced March 2021 most countries. COVID-19 vaccination coverage varied from low Cameroon Tanzania up 39.85% full Botswana at end 2021; that is, all doses advocated by initial protocols versus total population, rates increasing 58.4% June 2022. greatest increase people being fully vaccinated observed Uganda (20.4% increase), (18.5% Zambia (17.9% increase). Most were obtained through WHO-COVAX agreements. Initially, prioritised for healthcare workers (HCWs), elderly, adults co-morbidities, other at-risk groups, now commencing among children administering booster doses. Challenges included irregular supply considerable arising misinformation fuelled social media activities. Overall, fair reasonable access countries, enhanced government initiatives. must be addressed context-specific interventions, including proactive programmes HCWs, medical journalists, public.

Language: Английский

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Facilitators and barriers to vaccination uptake in pregnancy: A qualitative systematic review

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0298407 - e0298407

Published: April 19, 2024

Introduction Vaccination during pregnancy protects both the mother and foetus from vaccine-preventable diseases. However, uptake of recommended vaccines (influenza, pertussis, COVID-19) by pregnant women remains low in Europe USA. Understanding reasons for this is crucial to inform strategies increase vaccination rates women. This qualitative systematic review aimed identify barriers facilitators against influenza, pertussis/whooping cough COVID-19 possible rates. Methods We conducted a comprehensive search electronic databases, including Medline, PsycINFO, CINAHL, Web Science, WHO database, Embase grey literature studies that explored vaccine among (PROSPERO CRD42023399488). The was limited published between 2012 2022 high-income countries with established programmes pregnancy. Studies were thematically analysed underwent quality assessment using Joanna Briggs Institute validated critical appraisal tool research. Results Out 2681 articles screened, 28 (n = 1573 participants) eligible inclusion. Five overarching themes emerged relating personal, provider systemic factors. Barriers included concerns about safety efficacy, lack knowledge vaccines’ benefits necessity, fear adverse effects on or perception disease severity. Facilitators recommendations trusted healthcare providers, easy access vaccination, clear communication positive social influences family friends. Strategies increasing strong proactive professionals, provision routine antenatal care, consistent addressing women’s concerns. Conclusion highlights need interventions address identified Recommendation can play significant role promoting uptake, as risk/benefit convenient vaccination. Addressing providing accurate information also important.

Language: Английский

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