Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine
Neuropsychopharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 29, 2024
Language: Английский
A Systematic Review of the Neurocognitive Effects of Psychedelics in Healthy Populations: Implications for Depressive Disorders and Post-Traumatic Stress Disorder
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(3), P. 248 - 248
Published: March 3, 2024
Objective:
This
study
aims
to
provide
an
overview
of
pharmacological
trials
that
examine
the
neurocognitive
effects
psychedelics
among
healthy
individuals
and
patients
with
post-traumatic
stress
disorder
(PTSD)
or
major
depressive
(MDD).
Methods:
The
Preferred
Reporting
Items
for
Systematic
Reviews
(PRISMA)
was
used
as
a
guide
structure
report
findings
this
review.
A
literature
search
included
MEDLINE
database
up
until
December
2022.
We
randomized
open-label
human
studies
MDMA,
psilocybin,
mescaline,
LSD,
DMT,
cannabis
reporting
non-emotionally
charged
outcomes
(“cold
cognition”)
measured
through
validated
neuropsychological
tests.
Results:
total
43
full-text
papers
on
MDMA
(15),
(12),
LSD
(6),
psilocybin
(9),
DMT/ayahuasca
(1),
mescaline
(0)
were
included,
mostly
subjects.
single
article
MDMA’s
cognition
in
subjects
PTSD
included;
there
no
neurocognition
MDD.
Most
reported
detrimental
neutral
during
peak
effect
few
exceptions
(e.g.,
improved
psychomotor
function).
Performance
type
dimension
attention,
memory,
executive
function,
psychomotor)
varies
by
psychedelic,
dosage,
cognitive
testing.
Conclusions:
Small
samples
lack
uniformed
methods
across
preclude
unequivocal
conclusions
whether
enhance,
decrease,
have
significant
performance.
It
is
foreseen
will
soon
become
available
treatment
various
psychiatric
disorders.
acute
long-term
caused
should
be
assessed
future
studies.
Language: Английский
Thermal transformation of CBD, CBDA, and Δ9-THC during e-cigarette vaping: Identification of conversion products by GC-MS
Journal of Chromatography A,
Journal Year:
2025,
Volume and Issue:
unknown, P. 465909 - 465909
Published: March 1, 2025
Language: Английский
Naturalistic use of psychedelics does not modulate processing of self‐related stimuli (but it might modulate attentional mechanisms): An event‐related potentials study
Psychophysiology,
Journal Year:
2024,
Volume and Issue:
61(8)
Published: April 7, 2024
Abstract
Classic
psychedelics
are
able
to
profoundly
alter
the
state
of
consciousness
and
lead
acute
experiences
ego
dissolution
–
blurring
distinction
between
representations
self
external
world.
However,
whether
repeated
use
is
associated
with
more
prolonged
permanent
modifications
concept
remains
be
investigated.
Therefore,
we
conducted
a
preregistered,
cross‐sectional
study
in
which
experienced
users
(15
or
lifetime
psychedelics;
N
=
56)
were
compared
nonusers
(
57)
terms
neural
reactivity
Self‐name
(i.e.,
each
participant's
own
name)
stimulus,
known
robustly
activate
representation
self.
Two
control
stimuli
additionally
used:
an
Other‐name
as
passive
condition
no
reaction
was
required,
Target‐name
participants
provided
manual
response
thus
constituted
active
condition.
Analysis
amplitude
P300
ERP
component
evoked
by
Self‐
Target‐names
revealed
difference
nonusers.
psychedelic
exhibited
increased
during
perception
Other‐names.
In
addition,
comparison
nonusers,
smaller
increase
when
processing
task‐relevant
(in
relation
both
Other‐names).
our
data
suggests
that
regular
naturalistic
may
not
related
long‐term
changes
,
but
it
might
potentially
affect
allocation
attentional
resources
stimuli.
Language: Английский
Is Use of Psychedelic Drugs a Risk or Protective Factor for Late-Life Cognitive Decline?
Gerontology and Geriatric Medicine,
Journal Year:
2024,
Volume and Issue:
10
Published: Jan. 1, 2024
Common
age-related
health
conditions
can
lead
to
poor
mental
outcomes
and
deteriorate
cognition.
Additionally,
commonly
prescribed
medications
for
various
mental/physical
may
cause
adverse
reactions,
especially
among
older
adults.
Psychedelic
therapy
has
shown
positive
impacts
on
cognition
been
successful
in
treating
problems
without
long-lasting
adversities.
The
current
study
examines
the
association
between
psychedelic
drug
usage
cognitive
functions
middle-aged
Language: Английский
Silence between words: Is solitude important for relatedness?
Progress in brain research,
Journal Year:
2024,
Volume and Issue:
unknown, P. 153 - 190
Published: Jan. 1, 2024
Language: Английский
Psychedelic risks and benefits: A cross-sectional survey study
Journal of Psychopharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 29, 2024
Background:
As
classic
psychedelics’
therapeutic
potential
is
studied
and
their
popularity
continues
to
rise,
it
important
establish
relative
risks
benefits.
Previous
surveys
have
tended
use
convenience
sampling
on
social
media,
select
participants
who
had
either
extremely
positive
or
negative
effects,
not
compared
the
risk/benefit
profile
of
psychedelics
other
substances.
Aims:
To
address
these
limitations,
we
gathered
samples
from
an
opt-in
panel
service
using
quota-based
approximate
demographics
representing
US
Census
data,
did
pre-specify
experiences,
experiences
with
those
cannabis.
Methods:
We
conducted
two
studies,
one
a
between-subjects
design
(
n
=
743)
within-subjects
514),
in
which
recruited
reflected
prior
experience
cannabis
indicated
self-reported
benefits
associated
experience.
Results:
Results
that
first
most
memorable
psychedelic
were
greater
acute
challenging
effects
persisting
than
but
also
effects.
Common
predictors
included
various
qualities
(e.g.,
dose
level,
presence
others)
individual
differences
religiosity,
personality),
though
only
small
degree.
Conclusions:
These
findings
provide
more
nuanced
characterization
predictors.
Language: Английский
Naturalistic use of psychedelics does not modulate processing of self-related stimuli (but it might modulate attentional mechanisms): an event-related potentials study comparing non-users and experienced users of classic psychedelics
Published: Dec. 28, 2023
Classic
psychedelics
are
able
to
profoundly
alter
the
state
of
consciousness
and
lead
acute
experiences
ego
dissolution
–
blurring
distinction
between
representations
self
external
world.
However,
whether
repeated
use
is
associated
with
more
prolonged
permanent
modifications
concept
remains
be
investigated.
Therefore,
we
conducted
a
preregistered,
cross-sectional
study
in
which
experienced
users
(15
or
lifetime
psychedelics;
N
=
56)
were
compared
non-users
(N
57)
terms
neural
reactivity
Self-name
(i.e.,
each
participant’s
own
name)
stimulus,
known
robustly
activate
representation
self.
Two
control
stimuli
additionally
used:
an
Other-name
as
passive
condition
no
reaction
was
required;
Target-name
participants
provided
manual
response
thus
constituted
active
condition.
Analysis
amplitude
P300
ERP
component
evoked
by
revealed
difference
non-users.
comparison
non-users,
exhibited
smaller
increase
when
processing
task-relevant
(in
relation
both
Self-
Other-names).
our
data
suggests
that
regular
naturalistic
may
not
related
long-term
changes
self,
but
it
might
potentially
affect
allocation
attentional
resources
stimuli.
Language: Английский