Psychedelic therapy – refining the claim of a paradigm shift DOI Creative Commons
Helena D. Aicher, Max Wolff, Uwe Herwig

et al.

International Review of Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Oct. 3, 2024

The renewed interest in psychedelics as treatments for mental health disorders is often referred to the "Psychedelic Renaissance." This article assesses whether this resurgence truly constitutes a paradigm shift psychiatry, some proponents claim, or if it should be viewed an integration of existing therapeutic approaches. We explore historical contexts, noting that were extensively researched mid-20th century and argue many current claims about their novelty overlook prior knowledge research from period. While do introduce novel aspects, such rapid effects unique modes action, we challenge idea full shift, suggesting these developments are better understood enhancements frameworks rather than wholesale replacement. emphasize importance integrating within broader bio-psycho-social model combining pharmacological, psychological, contextual factors. potential psychotherapy has previously been described working "nonspecific amplifiers" psychological processes, introducing entirely new mechanisms. suggest balanced, integrative approach incorporates into care models, cautioning against "psychedelic exceptionalism" risk overselling revolutionary treatment.

Language: Английский

Psychedelic-assisted psychotherapy: where is the psychotherapy research? DOI
Jacob S. Aday, David Horton, Gisele Fernandes‐Osterhold

et al.

Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(8), P. 1517 - 1526

Published: May 24, 2024

Language: Английский

Citations

10
The intensity of the psychedelic experience is reliably associated with clinical improvements: a systematic review and meta-analysis DOI
Bruno Roméo, E. Kervadec, Baptiste Fauvel

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 172, P. 106086 - 106086

Published: March 1, 2025

Language: Английский

Citations

1
The conceptual framework for the therapeutic approach used in phase 3 trials of MDMA-assisted therapy for PTSD DOI Creative Commons
Kelley C. O’Donnell,

Lauren Okano,

Michael Alpert

et al.

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 4, 2024

Results from multiple recent studies support further evaluation of 3,4-methylenedioxymethamphetamine (MDMA) in conjunction with psychotherapy (i.e., MDMA-Assisted Therapy) the treatment post-traumatic stress disorder (PTSD). In two Phase 3 trials, Therapy comprised a short-term, intensive that included three sessions directly facilitated by MDMA (referred to as “experimental sessions”), well number non-drug sessions. This model aimed harness potential facilitate recall and processing traumatic memories, increase learning social context, integrating “top-down” “bottom-up” approaches trauma-focused care. To date, conceptual framework for this has not been described scientific literature. omission contributed misunderstandings about both theoretical underpinnings modality therapeutic approach emerges it. paper delineates psychotherapeutic concepts, theories, historical antecedents underlying inner-directed PTSD. Broadly speaking, centered concept participant’s inner healing intelligence primary agent change, relationship being core facilitative condition fostering self-directed movement toward recovery growth. Corollaries holistic, self-directed, relational, trauma-informed include non-pathologizing embodied experience (including possibility intense emotional somatic expression, experiences multiplicity, suicidal ideation, multigenerational transpersonal experiences), therapists’ own psychodynamic, somatic, awareness, empathic attunement, relational skillfulness, cultural humility. The use platform outperformed placebo 2 measured symptom reduction participants However, within-group comparisons also identified significant who did receive MDMA, lending empirical itself. addition comparative efficacy future research should investigate which elements underlie clinical benefit individuals

Language: Английский

Citations

6
Catalyst for change: Psilocybin’s antidepressant mechanisms—A systematic review DOI Creative Commons
Joshua Liebnau, Felix Betzler, André Kerber

et al.

Journal of Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Background: Recent clinical trials suggest promising antidepressant effects of psilocybin, despite methodological challenges. While various studies have investigated distinct mechanisms and proposed theoretical opinions, a comprehensive understanding psilocybin’s neurobiological psychological is lacking. Aims: Systematically review potential psilocybin. Methods: Search terms were generated based on existing evidence related to mechanisms. Following Preferred Reporting Items for Systematic Reviews Meta-Analysis guidelines, 15 systematically reviewed, exploring therapeutic change principles such as brain dynamics, emotion regulation, cognition, self-referential processing, connectedness, interpersonal functioning. Results: Within supportive setting, psilocybin promoted openness, cognitive neural flexibility, greater ability acceptance emotional experiences. A renewed sense connectedness the self, others, world emerged key experience. Imaging consistently found altered characterized by reduced global within default mode network connectivity, alongside increased between-network connectivity. Conclusions: Together, these changes may create fertile yet vulnerable window change, emphasizing importance set, guidance. The results that context, induce leveraging interplay between common psychotherapeutic factors. This complements view purely pharmacological effects, supporting multileveled approach reflects relevant dimensions including neurobiological, psychological, environmental

Language: Английский

Citations

0
Further education in psychedelic-assisted therapy – experiences from Switzerland DOI Creative Commons
Helena D. Aicher, Felix Müller,

Peter Gasser

et al.

BMC Medical Education, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 5, 2025

The growing interest in psychedelic-assisted therapy (PAT) for treating psychiatric disorders such as treatment-resistant depression, PTSD, and anxiety has led to an increasing demand specialized training. In Switzerland, MDMA, psilocybin, LSD are applied the framework of limited medical use exceptional treatment options since 2014. Swiss Medical Association Psychedelic Therapy (SÄPT) been a key player addressing need education, offering comprehensive, three-year training program physicians psychologists. This curriculum integrates theoretical knowledge with hands-on experience, emphasizing therapeutic relationship, ethical considerations, management altered states consciousness induced by psychedelics. article gives overview structure addresses topics covered through teaching retreats focusing on practical learning. However, these programs far exceeds supply. gap is expected widen psychedelics potentially become regulated prescription medications. response, several organizations have expanded their educational offerings, including further education trainings, workshops, conferences, symposia. Overall, there more comprehensive accessible meet demand. evolving landscape psychedelic research, regulatory changes, diverse patient populations require flexible adaptive models. As field progresses, it essential establish certification standards ensure continued quality safe effective PAT clinical trials practice.

Language: Английский

Citations

0
The Afterglow Inventory (AGI): Validation of a new instrument for measuring subacute effects of classic serotonergic psychedelics DOI
Tomislav Majić, Timo Torsten Schmidt,

Anna Gröticke

et al.

Journal of Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Background: Classic psychedelics such as psilocybin and lysergic acid diethylamide are anecdotally associated with the phenomenon of “psychedelic afterglow,” a set predominantly pleasant, temporary psychological effects reported after acute have subsided. Since post-acute crucial for therapeutic use psychedelics, an instrument to systematically assess subacute “afterglow” is needed. Aims: To create validate questionnaire quantify psychedelics. Methods: An international online survey was conducted in English German. Participants who had consumed psychedelic ( N = 1323) or another non-psychedelic substance (control group, 157) within past 4 weeks were included. initial list 97 items progressively reduced 24 items. Results: A 5-factor structure best fit data showed high internal consistency. The factors included (1) vitality, (2) transpersonal aspects, (3) inspiration/creativity, (4) interpersonal relationships, (5) relationship nature. final 24-item version Afterglow Inventory (AGI) effectively differentiated between group control group. overall AGI score positively correlated intensity r 0.165; p < 0.001) positive valence 0.251; effects. Conclusions: novel scale quantifying (“afterglow”) could lead better understanding interplay acute, subacute, long-term Insights also be gained into how different substances, dosages, extra-pharmacological factors, psychotherapy, might influence outcomes.

Language: Английский

Citations

0
Acute subjective effects of psychedelics in naturalistic group settings prospectively predict longitudinal improvements in trauma symptoms, trait shame, and connectedness among adults with childhood maltreatment histories DOI Creative Commons
C. J. Healy,

Aaron Frazier,

Stephen Kirsch

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111361 - 111361

Published: April 1, 2025

Studies of psychedelic use in naturalistic and clinical settings have suggested safety mental health benefits for adults with histories childhood maltreatment. Acute psychological mechanisms that predict therapeutic this population, however, yet to be determined. Two common group - organized ceremonies raves or other electronic dance music events might facilitate effects because the unique psychosocial environments they comprise. This prospective, longitudinal study sought investigate 2 primary questions: first, whether maltreatment planning drugs intent at would see enduring after their experiences; second, subjective dimensions acute experience associated lasting benefits. Eighty-five participants completed self-report measures month before, within days after, approximately months a planned ceremony rave assessing history; trauma symptoms, internalized (trait) shame, connectedness baseline follow-up; various experience. Mean scores posttraumatic stress disorder (PTSD) complex PTSD trait social connectedness, general significantly improved from 2-month follow-up (ds = 0.73-1.12). Longitudinal changes outcomes correlated These findings implications regarding both potential benefit among as well action psychedelics.

Language: Английский

Citations

0
Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences DOI
Bruno Roméo, E. Kervadec, Baptiste Fauvel

et al.

Journal of Psychoactive Drugs, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: April 25, 2025

Neurobiological effects and psychological models propose that psychedelics may promote flexibility, suggesting a transdiagnostic effect by disrupting maladaptive patterns. The objective of this study was therefore to investigate the determinants flexibility change following psychedelic use. This retrospective online survey included French individuals who had undergone significant experience. Participants were assessed for mystical experience intensity with MEQ-30, via AAQ-II, at three time points. Data analysis comprised descriptive statistics, correlation analysis, ANCOVA evaluate impact use variables on linear regression identify predictors changes. showed positive between improvements in especially 1-month post-experience (p < .01), during 6 months before .01). Key changes baseline AAQ-II scores, MEQ total scores frequent use, underlining interaction personal experiential factors determining therapeutic outcomes. In conclusion, highlights how be key influencing post-psychedelic potential value.

Language: Английский

Citations

0
A systematic review of income and education reporting in psychedelic clinical trials DOI

Daniel H. Grossman,

Kevin R. Madden, Nicky J. Mehtani

et al.

Nature Mental Health, Journal Year: 2025, Volume and Issue: 3(5), P. 567 - 574

Published: May 12, 2025

Language: Английский

Citations

0
Psychedelic therapy – refining the claim of a paradigm shift DOI Creative Commons
Helena D. Aicher, Max Wolff, Uwe Herwig

et al.

International Review of Psychiatry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Oct. 3, 2024

The renewed interest in psychedelics as treatments for mental health disorders is often referred to the "Psychedelic Renaissance." This article assesses whether this resurgence truly constitutes a paradigm shift psychiatry, some proponents claim, or if it should be viewed an integration of existing therapeutic approaches. We explore historical contexts, noting that were extensively researched mid-20th century and argue many current claims about their novelty overlook prior knowledge research from period. While do introduce novel aspects, such rapid effects unique modes action, we challenge idea full shift, suggesting these developments are better understood enhancements frameworks rather than wholesale replacement. emphasize importance integrating within broader bio-psycho-social model combining pharmacological, psychological, contextual factors. potential psychotherapy has previously been described working "nonspecific amplifiers" psychological processes, introducing entirely new mechanisms. suggest balanced, integrative approach incorporates into care models, cautioning against "psychedelic exceptionalism" risk overselling revolutionary treatment.

Language: Английский

Citations

3