Investigation of the Roles of the Adenosine A(2A) and Metabotropic Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis DOI Creative Commons

Anthony M. Cuozzo,

Loren D. Peeters,

Cristal D. Ahmed

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 182 - 182

Published: Jan. 24, 2025

The metabotropic glutamate receptor type 5 (mGlu5) and adenosine A(2A) form a mutually inhibitory heteromer with the dopamine D2 receptor, where activation of either mGlu5 or leads to reduced signaling. This study investigated whether mGlu5-positive allosteric modulator (PAM) an agonist treatment could mitigate sensorimotor gating deficits alter cyclic AMP response element-binding protein (CREB) levels in rodent neonatal quinpirole (NQ) model psychosis. F0 Sprague–Dawley rats were treated saline (1 mg/kg) from postnatal day 1 21 bred produce F1 generation. offspring underwent prepulse inhibition (PPI) testing 44 48 assess gating. PAM 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) CGS21680. Rats at least one NQ-treated parent showed PPI deficits, which alleviated by both CDPPB Sex differences noted across groups, CGS21680 showing greater efficacy than CDPPB. Additionally, CREB elevated nucleus accumbens (NAc), expression control levels. These findings suggest that targeting adenosinergic glutamatergic systems alleviates abnormal signaling, are associated

Language: Английский

Investigation of the Roles of the Adenosine A(2A) and Metabotropic Receptor Type 5 (mGlu5) Receptors in Prepulse Inhibition and CREB Signaling in a Heritable Rodent Model of Psychosis DOI Creative Commons

Anthony M. Cuozzo,

Loren D. Peeters,

Cristal D. Ahmed

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 182 - 182

Published: Jan. 24, 2025

The metabotropic glutamate receptor type 5 (mGlu5) and adenosine A(2A) form a mutually inhibitory heteromer with the dopamine D2 receptor, where activation of either mGlu5 or leads to reduced signaling. This study investigated whether mGlu5-positive allosteric modulator (PAM) an agonist treatment could mitigate sensorimotor gating deficits alter cyclic AMP response element-binding protein (CREB) levels in rodent neonatal quinpirole (NQ) model psychosis. F0 Sprague–Dawley rats were treated saline (1 mg/kg) from postnatal day 1 21 bred produce F1 generation. offspring underwent prepulse inhibition (PPI) testing 44 48 assess gating. PAM 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB) CGS21680. Rats at least one NQ-treated parent showed PPI deficits, which alleviated by both CDPPB Sex differences noted across groups, CGS21680 showing greater efficacy than CDPPB. Additionally, CREB elevated nucleus accumbens (NAc), expression control levels. These findings suggest that targeting adenosinergic glutamatergic systems alleviates abnormal signaling, are associated

Language: Английский

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