Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration DOI Creative Commons
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 20, 2023

Abstract There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human vivo post mortem studies. Understanding the consequences of for network function important to support translational guide future therapeutic strategies. To examine this relationship, we recruited 55 participants with syndromes associated degeneration 24 healthy controls. We measured density positron emission tomography using radioligand [ 11 C]UCB-J, which binds presynaptic vesicle glycoprotein SV2A, neurite dispersion diffusion magnetic resonance imaging, task-free imaging functional connectivity. Synaptic patients was reduced connectivity beyond atrophy. Functional moderated relationship between clinical severity. Our findings confirm importance syndromes, resulting effect on behaviour as a abnormal

Language: Английский

Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging DOI
Junhao Wu, Binyin Li, Jie Wang

et al.

Radiology, Journal Year: 2024, Volume and Issue: 313(2)

Published: Nov. 1, 2024

Plasma phosphorylated tau 181 (p-tau-181) and glial fibrillary acidic protein (GFAP) have potential predictive value for identifying synaptic density as measured using 18 F-SynVesT-1 brain PET; the relationship of plasma p-tau-181 GFAP with synapse loss might be influenced by aggregation rather than amyloid-β deposition or cortical thickness.

Language: Английский

Citations

3
An in vivo high-resolution human brain atlas of synaptic density DOI
Annette Johansen, Vincent Beliveau,

E. Colliander

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(33), P. e1750232024 - e1750232024

Published: July 12, 2024

Synapses are fundamental to the function of central nervous system and implicated in a number brain disorders. Despite their pivotal role, comprehensive imaging resource detailing distribution synapses human has been lacking until now. Here, we employ high-resolution PET neuroimaging healthy humans (17F/16M) create 3D atlas synaptic marker Synaptic Vesicle glycoprotein 2A (SV2A). Calibration absolute density values (pmol/ml) was achieved by leveraging postmortem autoradiography data. The unveils distinctive cortical subcortical gradients synapse that reflect functional topography hierarchical order from core sensory higher-order integrative areas—a diverges SV2A mRNA patterns. Furthermore, found positive association between IQ several areas. This new will help advance our understanding physiology pathogenesis disorders, serving as tool for future neuroscience research.

Language: Английский

Citations

2
Biomarkers of Synaptic Degeneration in Alzheimer’s Disease DOI
Qian Cheng,

Yiou Fan,

Pengfei Zhang

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102642 - 102642

Published: Dec. 1, 2024

Language: Английский

Citations

2
Longitudinal synaptic loss versus tau Braak staging in amnestic mild cognitive impairment DOI Creative Commons
Greet Vanderlinden, Michel Koole, Laura Michiels

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Abstract INTRODUCTION The longitudinal progression of synaptic loss in Alzheimer's disease (AD) and how it is affected by tau pathology remains poorly understood. METHODS Thirty patients with amnestic mild cognitive impairment (aMCI) 26 healthy controls underwent evaluations tau, vesicle protein 2A (SV2A), amyloid positron emission tomography. Twenty‐one aMCI 2‐year follow‐up (FU) investigations. RESULTS Tau levels increased longitudinally Braak regions III through VI but not I II. SV2A decreased all aMCI. Baseline was negatively associated early at FU across regions. change were decline. DISCUSSION accumulation reaches a plateau already the stage AD. In regions, association between baseline might reflect dysfunction caused pathology. Highlights reached patients. show widespread decrease (SV2A) over 2 years. predictive for loss. tau–SV2A relation showed individual variability negative cognition.

Language: Английский

Citations

2
Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration DOI Creative Commons
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Dec. 20, 2023

Abstract There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human vivo post mortem studies. Understanding the consequences of for network function important to support translational guide future therapeutic strategies. To examine this relationship, we recruited 55 participants with syndromes associated degeneration 24 healthy controls. We measured density positron emission tomography using radioligand [ 11 C]UCB-J, which binds presynaptic vesicle glycoprotein SV2A, neurite dispersion diffusion magnetic resonance imaging, task-free imaging functional connectivity. Synaptic patients was reduced connectivity beyond atrophy. Functional moderated relationship between clinical severity. Our findings confirm importance syndromes, resulting effect on behaviour as a abnormal

Language: Английский

Citations

6