Annals of Medicine and Surgery,
Journal Year:
2025,
Volume and Issue:
87(3), P. 1487 - 1505
Published: Feb. 26, 2025
Objective:
This
study
aims
to
conduct
a
bibliometric
analysis
of
the
triglyceride-glucose
(TyG)
index
in
relation
cardiovascular
disorders.
Methods:
Data
for
were
extracted
from
Web
Science
Core
Collection
database
on
13
July
2024.
We
utilized
VOSviewer,
CiteSpace,
and
Biblioshiny
tools
analysis.
Results:
The
revealed
marked
increase
research
outputs
TyG
recent
years,
peaking
with
137
publications
2023.
China
emerged
as
leading
contributor,
followed
by
USA.
Chinese
Academy
Medical
Sciences
Peking
Union
College
among
top
contributing
institutions.
Shouling
Wu
Shuohua
Chen
authors,
journal
Cardiovascular
Diabetology
publishing
most
articles
this
topic.
Keyword
identified
“insulin-resistance”
frequently
occurring
term,
“risk.”
Cluster
eleven
key
areas,
including
“percutaneous
coronary
intervention,”
“obesity
indicators,”
“arterial
stiffness,”
“heart
failure.”
Conclusion:
highlights
expanding
role
metabolic
research.
Key
clusters
such
percutaneous
intervention,
obesity
indicators,
arterial
stiffness,
heart
failure,
new-onset
hypertension,
predicting
outcomes,
subclinical
artery
disease
emphasize
its
wide
applicability
across
diverse
clinical
settings.
keyword
“risk”
was
underscoring
importance
risk
assessment,
alongside
growing
use
prognostic
applications.
These
findings
reflect
increasing
recognition
pivotal
biomarker
medicine
encourage
further
exploration
integration.
Current Tissue Microenvironment Reports,
Journal Year:
2024,
Volume and Issue:
5(3), P. 79 - 90
Published: Feb. 21, 2024
Abstract
Purpose
of
Review
Although
the
molecular
mechanism
insulin
resistance
involves
multiple
factors
and
several
intrinsic
extrinsic
mechanisms
have
been
identified,
this
comprehensive
review
provides
key
information
on
some
core
complex
interactions
molecules
involved
in
signaling
pathways
resistance.
Recent
Findings
Diabetes
Mellitus,
most
common
metabolic
disorder,
is
one
greatest
global
medical
challenges
at
present.
There
has
a
significant
increase
complications
associated
with
diabetes
such
as
heart
disorders,
stroke,
neuropathy,
dyslipidemia,
dysfunction-associated
steatotic
liver
disease,
nephropathy.
This
calls
for
immediate
strategic
action
to
combat
disorder.
Insulin
resistance,
characteristic
marker
type
2
condition
which
regulation
glucose
metabolism
body
tissues,
liver,
adipose
tissue,
skeletal
muscle,
becomes
disrupted.
It
generally
hyperglycemia,
hyperinsulinemia,
hyperlipidemia,
impaired
homeostasis.
Summary
Understanding
pathophysiological
critical
developing
new
therapeutic
strategies
treat
polygenic
multifactorial
condition.
Impairment
caused
by
lipotoxicity,
increased
adiposity,
enhanced
inflammatory
signaling,
endoplasmic
reticulum
stress,
adipokines,
mitochondrial
dysfunction,
free
fatty
acids,
dysfunctional
signaling.
Cardiovascular Diabetology,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 8, 2025
Among
hypertensive
cohorts
across
different
nations,
the
relationship
between
triglyceride-glucose
index
(TyG)
and
its
conjunction
with
obesity
metrics
in
relation
to
cardiovascular
disease
(CVD)
incidence
mortality
remains
be
elucidated.
This
study
enrolled
9,283,
164,357,
5,334
hypertensives
from
National
Health
Nutrition
Examination
Survey
(NHANES),
UK
Biobank
(UKBB),
Shanghai
Pudong
cohort.
The
related
outcomes
for
CVD
were
defined
by
multivariate
Cox
proportional
hazards
models,
Generalized
Additive
Models
Mendelian
randomization
analysis.
Mediation
analysis
explored
mediating
role
of
inflammatory
markers
above
relationships.
Five
measures
insulin
resistance
linked
death
a
U-shaped
pattern,
highest
group
having
risk
increases.
Higher
glucose
triglyceride-waist
height
ratio
(TyG-WHTR)
was
higher
all-cause
(UKBB:
HR
1.21,
95%CI
1.16–1.26,
NHANES:
1.17,
1.00–1.36),
1.36,
1.23–1.49,
1.32,
1.00–1.72)
risks.
In
China
cohort,
triglyceride/high-density
lipoprotein-cholesterol
(TG/HDL_C)
associated
risks
stroke
(HR
1.31,
1.00–1.73
1.67,
1.06–2.63).
Inflammation
like
systemic
response
(SIRI)
C-reactive
protein
(CRP)
partially
explained
these
links,
CRP
stronger
effect.
Genetically
predicted
TyG
also
(OR
1.26,
1.10–1.45)
risk.
An
elevated
indices
are
significantly
correlated
an
increased
three
national
cohorts.
These
anticipated
serve
as
valid
predictors
incident
individuals
hypertension.
Cardiovascular Diabetology,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Aug. 24, 2023
Abstract
Background
Diabetes
and
hyperlipidaemia
are
both
risk
factors
for
coronary
artery
disease,
associated
with
a
high
triglyceride-glucose
index
(TyG
index).
The
TyG
has
been
presented
as
marker
of
insulin
resistance
(IR).
Its
utility
in
predicting
detecting
cardiovascular
disease
reported.
However,
few
studies
have
found
it
to
be
helpful
atherosclerosis
patients
symptomatic
(CAD).
purpose
this
study
was
demonstrate
that
the
can
serve
valuable
carotid
CAD
patients,
regardless
diabetes
mellitus
hyperlipidaemia.
Methods
This
included
1516
who
underwent
angiography
Doppler
ultrasound
Department
Cardiology
at
Tianjin
Union
Medical
Center
from
January
2016
December
2022.
determined
using
Ln
formula.
population
further
grouped
analysed
according
presence
or
absence
Gensini
score
intima-media
thickness
were
calculated
measured,
divided
into
four
groups
quartile
examine
relationship
between
lesions
patients.
Results
In
showed
significant
positive
correlation
plaques.
After
adjusting
sex,
age,
smoking,
BMI,
hypertension,
diabetes,
use
antilipemic
antidiabetic
agents,
developing
plaques
increased
across
baseline
index.
Compared
lowest
index,
highest
(quartile
4)
greater
incidence
heart
[OR
=
2.55
(95%
CI
1.61,
4.03)]
atherosclerotic
plaque
2.31
1.27,
4.20)]
(
P
<
0.05).
Furthermore,
when
compared
fasting
blood
glucose
(FBG)
triglyceride
(TG)
level,
had
area
under
ROC
curve
subgroup
analysis
demonstrated
an
equally
effective
predictor
Conclusion
is
useful
CAD,
higher
value
identification
than
FBG
TG
level
alone.
Cardiovascular Diabetology,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: May 13, 2024
Abstract
Background
The
relationship
between
the
triglyceride–glucose
(TyG)
index
and
risk
of
cardiovascular
disease
(CVD)
in
U.S.
population
under
65
years
age
with
diabetes
or
prediabetes
is
unknown.
purpose
this
study
was
to
investigate
baseline
TyG
CVD
patients
prediabetes.
Methods
We
used
data
from
2003–2018
National
Health
Nutrition
Examination
Survey
(NHANES).
Multivariate
regression
analysis
models
were
constructed
explore
risk.
Nonlinear
correlations
explored
using
restricted
cubic
splines.
Subgroup
interaction
tests
also
conducted.
Results
enrolled
a
total
4340
participants
pre-diabetes,
mean
9.02
±
0.02.
overall
average
prevalence
10.38%.
Participants
higher
quartiles
showed
high
rates
(Quartile
1:
7.35%;
Quartile
2:
10.04%;
3:
10.71%;
4:
13.65%).
For
CVD,
possible
association
observed.
Our
findings
suggested
linear
CVD.
results
revealed
U-shaped
both
(P
nonlinear
=
0.02583)
CHF
0.0208)
individuals
diabetes.
term
indicated
that
there
no
significant
difference
among
different
stratifications.
positive
comorbid
MetS
Conclusions
A
linked
an
increased
likelihood
aged
≤
Besides,
assessment
will
contribute
more
convenient
effective
screening
high-risk
MetS.
Future
studies
should
whether
interventions
targeting
may
improve
clinical
outcomes
these
patients.
ESC Heart Failure,
Journal Year:
2024,
Volume and Issue:
11(3), P. 1317 - 1328
Published: Jan. 21, 2024
Abstract
Percutaneous
coronary
intervention
(PCI)
addresses
myocardial
ischaemia,
but
a
significant
subset
of
patients
encounter
major
adverse
cardiovascular
events
(MACE)
post‐treatment.
This
meta‐analysis
investigated
the
relationship
between
post‐PCI
triglyceride‐glucose
(TyG)
index
and
MACE.
Comprehensive
searches
Embase,
PubMed,
Cochrane
Library,
Web
Science
databases
were
conducted
up
to
3
March
2023,
using
relevant
keywords.
The
effect
size
was
determined
based
on
I
2
statistic
random‐effects
models.
Cluster‐robust
standard
errors
crafted
dose–response
curve,
GRADE
Evaluation
Scale
employed
rate
quality
evidence.
group
with
highest
TyG
had
significantly
higher
MACE
rates
than
lowest
group,
hazard
ratios
(HRs)
2.04
(95%
CI
1.65–2.52;
=
77%).
Each
unit
increase
in
corresponded
HRs
1.82
for
1.34–2.46;
92%),
2.57
non‐fatal
MI
1.49–4.41;
63%),
2.06
revascularization
1.23–3.50;
90%).
A
linear
risk
established
(
R
0.6114).
For
all‐cause
mortality,
HR
1.93
1.35–2.75;
50%),
indicating
mortality
elevated
index.
assessment
yielded
high
certainty
low
revascularization,
may
predict
risks
MACE,
MI,
varied
levels
certainty.
potential
association
identified.
Future
research
should
validate
these
findings.
Frontiers in Cardiovascular Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: March 13, 2024
Cardiovascular
mortality
is
still
excessively
high,
despite
the
considerable
progress
made
in
prevention
and
treatment
of
cardiovascular
diseases.
Although
many
risk
factors
(such
as
arterial
hypertension,
hypercholesterolemia,
diabetes,
etc.),
identified
general
population,
are
being
promptly
treated,
to
date
little
consideration
given
a
factor
which
we
believe
has
largely
demonstrated
scientific
literature
last
three
decades
that,
if
neglected,
can
produce
series
relevant
negative
effects
on
system:
insulin
resistance
(IR)/hyperinsulinemia
(Hyperins).
This
not
sufficently
sought
population
and,
consequently,
treated
promptly,
it
should
be,
avoid
its
impact
system.
IR's
prevalence
constantly
growing
worldwide,
estimated
have
reached
51%
developed
developing
countries,
Hyperins
constant
strong
feature
IR.
article
aims
stimulate
community
towards
IR/Hyperins
factor,
since
neglected.
The
analyzed
used
for
this
was
found
PubMed,
Scopus,
Science
Direct,
etc,
using
following
keywords:
insulin,
signaling,
resistance,
hyperinsulinemia,
factors,
system,
We
selected
studies
that
explored
association
between
those
discussed
possibilities
screening
IR/Hyperins.
