Treatments for Burning Mouth Syndrome: A Network Meta-analysis DOI
Rachel Alvarenga‐Brant,

F.O. Costa,

Gustavo Henrique Mattos Pereira

et al.

Journal of Dental Research, Journal Year: 2022, Volume and Issue: 102(2), P. 135 - 145

Published: Oct. 8, 2022

The aim of this systematic review and network meta-analysis (NMA) randomized controlled trials was to evaluate the effectiveness treatments for pain relief burning mouth syndrome (BMS). Five databases gray literature were searched. Independent reviewers selected studies, extracted data, assessed risk bias. primary outcome or sensation, secondary outcomes side effects, quality life, salivary flow, TNF-α interleukin 6 levels. Four comparable interventions grouped into different geometries ensure transitivity assumption pain: photobiomodulation therapy, alpha-lipoic acid, phytotherapics, anxiolytics/antidepressants. Mean difference (MD) 95% CI calculated continuous outcomes. minimal important consider a therapy beneficial against placebo an MD at least −1 pain. To interpret results, GRADE approach NMA used with minimally contextualized framework magnitude effect. Forty-four included (24 in NMA). anxiolytic (clonazepam) probably reduces BMS when compared (MD, −1.88; CI, −2.61 −1.16; moderate certainty). Photobiomodulation −1.90; −3.58 −0.21) pregabalin −2.40; −3.49 −1.32) achieved effect low very certainty. Among all tested treatments, only clonazepam is likely reduce placebo. majority other had certainty, mainly due imprecision, indirectness, intransitivity. More comparing are encouraged confirm evidence test possible alternative (PROSPERO CRD42021255039).

Language: Английский

Pharmacological Management of Orofacial Pain DOI
Marcela Romero‐Reyes, Sherwin Arman,

Antonia Teruel

et al.

Drugs, Journal Year: 2023, Volume and Issue: 83(14), P. 1269 - 1292

Published: Aug. 26, 2023

Language: Английский

Citations

17
Photobiomodulation alleviates Burning Mouth Syndrome pain: Immediate and weekly outcomes explored DOI

Ori Finfter,

Layla Kizel,

Rakefet Czerninski

et al.

Oral Diseases, Journal Year: 2024, Volume and Issue: 30(7), P. 4668 - 4676

Published: Feb. 23, 2024

Burning Mouth Syndrome (BMS) is an intraoral chronic burning or dysesthetic sensation, without clinically evident causative lesions on clinical examination and investigation.

Language: Английский

Citations

7
Is burning mouth syndrome associated with stress? A meta‐analysis DOI Creative Commons
André Luís Porporatti, Ângela Graciela Deliga Schröder,

Ashley Lebel

et al.

Journal of Oral Rehabilitation, Journal Year: 2023, Volume and Issue: 50(11), P. 1279 - 1315

Published: June 19, 2023

Some studies have shown burning mouth syndrome (BMS) as comorbid psychosocial and psychiatric disorders, well, pointed at stress a major risk factor.The aim of this meta-analysis was to answer the following question: 'Is there an association between BMS stress, compared healthy controls?'Two reviewers searched for effect in published on five main databases three from grey literature. Various questionnaires biomarkers were analysed. Of 2489 selected articles, 30 met inclusion criteria. Studies englobed questionnaires, such Perceived Stress Questionnaire, Lipp Symptoms Inventory, Holmes-Rahe scale, Depression, Anxiety, Scale (DASS-21), Recent Experience Test; various biomarkers, cortisol, opiorphin, IgA, α-amylase interleukins.In all with significantly increased group vs. control. Patients presented 25.73% higher cortisol levels, 28.17% IgA levels 40.62% than controls. Meta-analysis found that subjects 3.01 nmoL/L [0.53; 5.50] 84.35 kU/L [15.00; 153.71] 29.25 mg/mL [9.86; 48.64] 258.59 pg/mL [59.24; 457.94] IL-8 No differences opiorphin concentration ng/mL [-0.96; 2.53]. For interleukins, no founded IL-1 β, IL-2, IL-4, IL-6, IL-8, IL-10 TNF-α.Based available evidence, suggests more factors questionnaire-based studies, α-amylase,

Language: Английский

Citations

13
Orofacial Pain and Dentistry Management: Guidelines for a More Comprehensive Evidence-Based Approach DOI Creative Commons

Mauro Labanca,

Marzia Gianò, Caterina Franco

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(17), P. 2854 - 2854

Published: Sept. 4, 2023

Orofacial pain represents one of the most common health problems that negatively affects activities daily living. However, mechanisms underlying these conditions are still unclear, and their comprehensive management is often lacking. Moreover, even if a symptom in dentistry, differential diagnostic procedures needed to exclude other origins. Misinterpretation origin, fact, can lead misdiagnosis subsequent mismanagement. Pain orofacial area reason for patients visit dentist, but this complex, could be associated with hard soft tissues head, face, oral cavity, or dysfunction nervous system. Considering origins many varied, thorough assessment situation necessary enable appropriate pathway followed achieve optimal clinical therapeutic management.

Language: Английский

Citations

13
Oral Microbiome, Oral Health and Systemic Health: A Multidirectional Link DOI Creative Commons
Elena Maria Varoni, Lia Rimondini

Biomedicines, Journal Year: 2022, Volume and Issue: 10(1), P. 186 - 186

Published: Jan. 17, 2022

The oral cavity can be regarded as the mirror of systemic health, since many diseases may have manifestations in cavity, case, among oral, potentially malignant disorders, lupus erythematosus lichenoid lesions, and, vice-versa, affect impairing patient's nutrition and wellbeing, reducing quality life increasing stress anxiety [...].

Language: Английский

Citations

21
Oral manifestations serve as potential signs of ulcerative colitis: A review DOI Creative Commons
Chunyu Li, Yuqi Wu, Yulang Xie

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 29, 2022

As an immune dysregulation-related disease, although ulcerative colitis (UC) primarily affects the intestinal tract, extraintestinal manifestations of disease are evident, particularly in oral cavity. Herein, we have reviewed various presentations, potential pathogenesis, and treatment lesions related to UC. The UC include specific nonspecific manifestations, with former including pyostomatitis vegetans latter encompassing recurrent aphthous ulcers, atrophic glossitis, burning mouth syndrome, angular cheilitis, dry mouth, taste change, halitosis, periodontitis. Although aetiology has not been fully determined, factors leading its development system dysregulation, dysbiosis, malnutrition. principle treating is relieve pain, accelerate healing lesions, prevent secondary infection, primary procedure control diseases. Systemic corticosteroids preferred options, besides, topical systemic administration combined dietary guidance can also be applied. Oral might accompany or precede diagnosis UC, albeit absence symptoms; therefore, especially vegetans, ulcer periodontitis, could used as good mucocutaneous signs judge occurrence severity thus facilitating early avoiding severe consequences, such colon cancer.

Language: Английский

Citations

19
Diagnosis and treatment of intractable idiopathic orofacial pain with attention-deficit/hyperactivity disorder DOI Creative Commons
Satoshi Kasahara,

Kaori Takahashi,

Ko Matsudaira

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 30, 2023

Abstract Attention-deficit/hyperactivity disorder (ADHD) has been reported to be associated with primary chronic pain syndromes, such as fibromyalgia, migraine, and low back pain. Although idiopathic orofacial (IOP) is classified burning mouth syndrome or persistent facial dentoalveolar a pain, the association between IOP ADHD not investigated. This retrospective cohort study investigated severity of symptoms measured using scale effects treatment drugs dopamine system stabilizer aripiprazole. The participants were 25 consecutive patients refractory referred psychiatrist diagnosed coexisting according Diagnostic Statistical Manual Mental Disorders-5. scores higher in intractable than those general population. Pharmacotherapy used this led clinically significant improvements anxiety/depression, catastrophizing. Intractable shown associated. In future, screening pharmacotherapy for should considered IOP.

Language: Английский

Citations

13
Therapeutic effects of clonazepam in patients with burning mouth syndrome and various symptoms or psychological conditions DOI Creative Commons

Hyun-Il Shin,

Joo-In Bang,

Geun‐Jeon Kim

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 4, 2023

Abstract Burning mouth syndrome (BMS) is frequently accompanied by dysgeusia and xerostomia. Clonazepam has been widely prescribed effective, but it unclear whether clonazepam also affects the symptoms that accompany BMS, or such affect treatment outcomes. Here, we investigated therapeutic outcomes in BMS patients with various comorbidities. We retrospectively reviewed 41 diagnosed between June 2010 2021 at a single institution. Patients were instructed to take for 6 weeks. Before first dose, burning pain intensity was measured using visual analog scale (VAS); unstimulated salivary flow rate (USFR), psychologic characteristics, site(s) of pain, any taste disturbance evaluated. again after Thirty-one patents (75.7%) exhibited depressed mood, whereas more than 67.8% anxiety. Subjective xerostomia reported ten (24.3%). The mean 0.69 mL/min hyposalivation (an ≤ 0.5 mL/min) apparent Dysgeusia present 20 (48.7%); bitter (n = 15, 75%) largest proportion patients. who responded best terms reduction weeks 4, 26.6%). Overall, 32 (78%) decreased oral (mean VAS score changed from 6.56 5.34) use. disturbances significantly greater decrease compared other 6.41 4.58) ( p 0.02). improved had disturbances.

Language: Английский

Citations

12
Orofacial pain for clinicians: A review of constant and attack-like facial pain syndromes DOI Creative Commons
Arne May, Rafael Benoliel, Yoshiki Imamura

et al.

Cephalalgia, Journal Year: 2023, Volume and Issue: 43(8)

Published: Aug. 1, 2023

Background Primary headache syndromes such as migraine are among the most common neurological syndromes. Chronic facial pain of non-odontogenic cause less well known to neurologists despite being highly disabling. Given localization, these patients often consult dentists first who may conduct unnecessary dental interventions even if a is not identified. Once it becomes clear that modalities have no effect on pain, be referred another dentist or orofacial specialist, and later neurologist. Unfortunately, also familiar with chronic although they share neural system, i.e., trigeminal nerve central processing areas for disorders. Conclusion In essence, three broad groups important clinicians: (i) Attack-like conditions, which encompass neuralgias cranial nerves well-known variants primary syndromes; (ii) persistent disorders, including neuropathic idiopathic facial/dentoalveolar pain; (iii) other differential diagnostically relevant conditions encountered by clinicians painful temporomandibular bruxism, sinus others interfere (trigger) overlap headache. It rewarding know recognize clinical picture syndromes, given that, just like headache, an internationally accepted classification system has been published many can treated medications generally used

Language: Английский

Citations

12
Oral Health Knowledge, Self-Assessed Oral Health Behavior, and Oral Hygiene Practices among the Adult General Population in Croatia DOI Open Access
Antonija Tadin, Marija Badrov

Healthcare, Journal Year: 2023, Volume and Issue: 12(1), P. 88 - 88

Published: Dec. 30, 2023

Emphasizing the significance of optimal oral health for enhancing overall well-being, this study aimed to investigate knowledge, self-assessed behaviors, and hygiene practices within Croatian general population.

Language: Английский

Citations

12