Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis DOI Creative Commons
Lan Li, Jie Li,

Jianjiang Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 23, 2024

Osteoarthritis (OA) is the most common type of arthritis characterized by progressive cartilage degradation, with its pathogenesis closely related to chondrocyte autophagy. Chondrocytes are only cells in articular cartilage, and function chondrocytes plays a vital role maintaining homeostasis. Autophagy, an intracellular degradation system that regulates energy metabolism cells, incredibly important OA. During early stages OA, autophagy enhanced chondrocytes, acting as adaptive mechanism protect them from various environmental changes. However, progress gradually decreases, leading accumulation damaged organelles macromolecules within cell, prompting apoptosis. Numerous studies have shown influenced senescence apoptosis which associated reduced The relationship between autophagy, senescence, complex. While generally believed inhibit cellular promote cell survival, recent some proteins degraded selective secretion senescence-associated secretory phenotype (SASP) or increased SA-β-Gal activity senescent region human OA cartilage. Autophagy activation may lead different outcomes depending on timing, duration, activation. Thus, our study explored complex well regulatory molecules signaling pathways, providing new insights for future development safe effective drugs targeting improve

Language: Английский

Chondrocyte autophagy mechanism and therapeutic prospects in osteoarthritis DOI Creative Commons
Lan Li, Jie Li,

Jianjiang Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 23, 2024

Osteoarthritis (OA) is the most common type of arthritis characterized by progressive cartilage degradation, with its pathogenesis closely related to chondrocyte autophagy. Chondrocytes are only cells in articular cartilage, and function chondrocytes plays a vital role maintaining homeostasis. Autophagy, an intracellular degradation system that regulates energy metabolism cells, incredibly important OA. During early stages OA, autophagy enhanced chondrocytes, acting as adaptive mechanism protect them from various environmental changes. However, progress gradually decreases, leading accumulation damaged organelles macromolecules within cell, prompting apoptosis. Numerous studies have shown influenced senescence apoptosis which associated reduced The relationship between autophagy, senescence, complex. While generally believed inhibit cellular promote cell survival, recent some proteins degraded selective secretion senescence-associated secretory phenotype (SASP) or increased SA-β-Gal activity senescent region human OA cartilage. Autophagy activation may lead different outcomes depending on timing, duration, activation. Thus, our study explored complex well regulatory molecules signaling pathways, providing new insights for future development safe effective drugs targeting improve

Language: Английский

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