Possibilities of the capnometry method in the diagnosis of post-COVID-19 disorders DOI Creative Commons

A. I. Mikhailovicheva,

P. V. Struchkov, N. S. Nosenko

et al.

Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, Journal Year: 2025, Volume and Issue: 1, P. 35 - 38

Published: March 31, 2025

Relevance. This work presents the diagnostic capabilities of capnometry and spirometry methods in individuals with a mild form COVID-19 infection. Objective. To assess changes external respiration parameters patients Materials methods. The results examination 2 groups were analyzed. Group 1 included 30 subjects after infection, 10 men 20 women, average age 56.3 ± 4.2 years. group was also divided into people depending on period infection: 3 months, 6 months 9–10 months. healthy volunteers: 16 14 45.6 2.4 Results. Two examined: I — who had COVID-19, II volunteers. Capnometry revealed statistically significant increase alveolar phase slope infection compared control during quiet breathing deep exhalation, statistical differences Toulu index revealed. According to data, no difference found FEV1, FVC, FEV1/FVC ratio. Conclusion. method ventilation-perfusion disturbances for No spirometric noted can be recommended identify persistent have COVID-19.

Language: Английский

Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals DOI Creative Commons
Juliane Brun, Edi Dharmana, Michelle L. Hill

et al.

Antiviral Research, Journal Year: 2025, Volume and Issue: unknown, P. 106123 - 106123

Published: Feb. 1, 2025

Language: Английский

Citations

0
Morphopathology of the lesions induced by SARS-CoV-2 infection in the lungs DOI Open Access

Florin Ionuț Buibaș,

Roberta Andreea Cercel,

Mircea-Sebastian Șerbănescu

et al.

Romanian Journal of Morphology and Embryology, Journal Year: 2025, Volume and Issue: 65(4), P. 637 - 645

Published: Feb. 13, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spread rapidly from China around the world, causing worst pandemic since beginning of 21st century. Although disease named 2019 (COVID-19) has multiple organ symptoms, main pathological lesions occur in lung, failure, pulmonary embolism, secondary bacterial pneumonia and fibrosis. Despite best efforts researchers, pathogenesis SARS-CoV-2-induced cellular tissue damage organs systems is poorly understood. Therefore, our study, we aimed to highlight their extent, which could explain complex symptomatology presented by patients who died with distress (ARDS). The study was performed on a number 36 diagnosed COVID-19 under legally suspicious conditions, requiring autopsy within Romanian Forensic Medicine Institutes. All local inflammatory reaction pneumonic type, exudative proliferative phenomena, intra-alveolar interstitial infiltrates formed lymphocytes, macrophages neutrophilic granulocytes, congested or ruptured blood vessels hemorrhages, thrombosis, proliferation fibroblasts transformed into myofibroblasts presence granulation that remodeled entire lung parenchyma.

Language: Английский

Citations

0
Possibilities of the capnometry method in the diagnosis of post-COVID-19 disorders DOI Creative Commons

A. I. Mikhailovicheva,

P. V. Struchkov, N. S. Nosenko

et al.

Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice, Journal Year: 2025, Volume and Issue: 1, P. 35 - 38

Published: March 31, 2025

Relevance. This work presents the diagnostic capabilities of capnometry and spirometry methods in individuals with a mild form COVID-19 infection. Objective. To assess changes external respiration parameters patients Materials methods. The results examination 2 groups were analyzed. Group 1 included 30 subjects after infection, 10 men 20 women, average age 56.3 ± 4.2 years. group was also divided into people depending on period infection: 3 months, 6 months 9–10 months. healthy volunteers: 16 14 45.6 2.4 Results. Two examined: I — who had COVID-19, II volunteers. Capnometry revealed statistically significant increase alveolar phase slope infection compared control during quiet breathing deep exhalation, statistical differences Toulu index revealed. According to data, no difference found FEV1, FVC, FEV1/FVC ratio. Conclusion. method ventilation-perfusion disturbances for No spirometric noted can be recommended identify persistent have COVID-19.

Language: Английский

Citations

0