Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder DOI Creative Commons
Simeng Liu,

Huayuan Xi,

Xia Xue

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 21, 2024

Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that has been found to be associated with dysregulation of gastrointestinal functions and gut microbial homeostasis (the so-called “gut-brain axis”). ASD often accompanied by poor performances in social interaction repetitive behaviors. Studies on the gut-brain axis provide novel insights candidate targets for therapeutics diagnosis. Based mice model, this work aims reveal mechanisms behind intestinal barrier function probiotics mouse models. Results We an altered both BTBR T + Itpr3 tf /J ( BTBR) valproic acid (VPA) mice, including increased permeability, decreased expression tight junction proteins (claudin1, claudin3, occludin), levels IL-6, TNF-α, IFN-γ. alternation, C. butyricum can drive reduced histone deacetylases 1 (HDAC1) enhanced function, significantly promoting behavioral abnormalities mice. In parallel, we confirmed was involved regulation Trek1 channel, indicating it target C . /butyric improve Conclusions Our finding provides solid evidence microbiota through brain-gut axis. addition, hold promise health ameliorate ASD.

Language: Английский

Lead exposure induces neurodysfunction through caspase-1-mediated neuronal pyroptosis DOI
Dongjie Peng, Leilei Wang, Yuanyuan Fang

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 255, P. 119210 - 119210

Published: May 23, 2024

Language: Английский

Citations

2
Treatment of Manganese and Lead Poisoning with Sodium Para-aminosalicylic Acid：A Contemporary Update DOI
Yuhan Xie,

Han‐xiao Song,

Jianchao Peng

et al.

Toxicology Letters, Journal Year: 2024, Volume and Issue: 398, P. 69 - 81

Published: June 22, 2024

Language: Английский

Citations

1
Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder DOI Creative Commons
Simeng Liu,

Huayuan Xi,

Xia Xue

et al.

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 21, 2024

Abstract Background Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that has been found to be associated with dysregulation of gastrointestinal functions and gut microbial homeostasis (the so-called “gut-brain axis”). ASD often accompanied by poor performances in social interaction repetitive behaviors. Studies on the gut-brain axis provide novel insights candidate targets for therapeutics diagnosis. Based mice model, this work aims reveal mechanisms behind intestinal barrier function probiotics mouse models. Results We an altered both BTBR T + Itpr3 tf /J ( BTBR) valproic acid (VPA) mice, including increased permeability, decreased expression tight junction proteins (claudin1, claudin3, occludin), levels IL-6, TNF-α, IFN-γ. alternation, C. butyricum can drive reduced histone deacetylases 1 (HDAC1) enhanced function, significantly promoting behavioral abnormalities mice. In parallel, we confirmed was involved regulation Trek1 channel, indicating it target C . /butyric improve Conclusions Our finding provides solid evidence microbiota through brain-gut axis. addition, hold promise health ameliorate ASD.

Language: Английский

Citations

1