When Do Tumours Develop? Neoplastic Processes Across Different Timescales: Age, Season and Round the Circadian Clock DOI Creative Commons
Margaux Bieuville, Antoine M. Dujon, Nynke Raven

et al.

Evolutionary Applications, Journal Year: 2024, Volume and Issue: 17(10)

Published: Oct. 1, 2024

ABSTRACT While it is recognised that most, if not all, multicellular organisms harbour neoplastic processes within their bodies, the timing of when these undesirable cell proliferations are most likely to occur and progress throughout organism's lifetime remains only partially documented. Due different mechanisms implicated in tumourigenesis, highly unlikely this probability constant at all times stages life. In article, we summarise what known about variation, considering roles age, season circadian rhythm. studies requiring level detail be done on humans, also review available evidence other animal species. For each timescales, identify or biological functions shaping variation. When possible, show evolutionary played a role, either directly regulate cancer risk indirectly through trade‐offs. We find varies with age more complex way than predicted by early epidemiological models: rather resulting from mutations alone, tumour development dictated tissue‐ age‐specific processes. Similarly, seasonal cycle can associated variation some species life‐history events such as sexual competition mating being timed according season. Lastly, influences tumourigenesis physiological, pathological therapeutic contexts. highlight two core variations across our three timescales: immunity metabolism. Finally, understanding entanglement between tumourigenic cycles constrained limited number for which have extensive data. Improving knowledge periods vulnerability onset and/or progression (malignant) tumours key issue deserves further investigation, successful prevention strategies.

Language: Английский

Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research DOI Creative Commons
Rachel S. Edgar, Aidan J. O’Donnell, Xiaodong Zhuang

et al.

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1918)

Published: Jan. 23, 2025

The discovery of rhythmicity in host and pathogen activities dates back to the Hippocratic era, but causes consequences these biological rhythms have remained poorly understood. Rhythms infection phenotypes or traits are observed across taxonomically diverse hosts pathogens, suggesting general evolutionary principles. Understanding principles may enable be leveraged manners that improve drug vaccine efficacy disrupt timekeeping reduce virulence transmission. Explaining exploiting infections require an integrative multidisciplinary approach, which is a hallmark research within chronobiology. Many researchers welcomed into chronobiology from other fields after observing unexpected rhythm time-of-day effect their data. Such findings can launch rich new topic, engaging with concepts, approaches dogma discipline daunting. Fortunately, has well-developed frameworks for interrogating readily applied novel contexts. Here, we provide ‘how to’ guide exploring daily infectious disease research. We outline how establish: whether circadian, what extent responsible, relevance host–pathogen interactions, explore therapeutic potential. This article part Theo Murphy meeting issue ‘Circadian immunity’.

Language: Английский

Citations

0
Journal Club Commentaries: An Invitation for Chronobiology Trainees to Share Their Ideas DOI Creative Commons
Mary E. Harrington

Journal of Biological Rhythms, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

0
Circadian Medicine Education: The Time Has Arrived DOI Creative Commons
Horacio O. de la Iglesia, John B. Hogenesch

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: 39(6), P. 511 - 512

Published: Nov. 14, 2024

Language: Английский

Citations

1
Practical Advice on Measuring and Applying Light for Laboratory Mammals DOI
Robert J. Lucas, Stuart N. Peirson

Journal of Biological Rhythms, Journal Year: 2024, Volume and Issue: 39(4), P. 323 - 330

Published: July 31, 2024

Light is recognized as an important component of the environment for laboratory animals. It supports vision, sets phase circadian clocks, and drives wide-ranging adjustments in physiological behavioral state. Manipulating light meanwhile a key experimental approach fields vision science chronobiology. Nevertheless, until recently, there has been no consensus on methods quantifying experienced by Widely adopted practices employ metrics such illuminance (units = lux) that are designed to quantify human observers. These weight energy across spectrum according spectral sensitivity profile not widely replicated non-human species. Recently, Consensus View was published proposes measurement standardization take account these species-specific differences wavelength sensitivity. Here, we draw upon contents provide simplified advice mammal experimentation husbandry quantitative guidance what constitutes appropriate lighting both visual function.

Language: Английский

Citations

0
When Do Tumours Develop? Neoplastic Processes Across Different Timescales: Age, Season and Round the Circadian Clock DOI Creative Commons
Margaux Bieuville, Antoine M. Dujon, Nynke Raven

et al.

Evolutionary Applications, Journal Year: 2024, Volume and Issue: 17(10)

Published: Oct. 1, 2024

ABSTRACT While it is recognised that most, if not all, multicellular organisms harbour neoplastic processes within their bodies, the timing of when these undesirable cell proliferations are most likely to occur and progress throughout organism's lifetime remains only partially documented. Due different mechanisms implicated in tumourigenesis, highly unlikely this probability constant at all times stages life. In article, we summarise what known about variation, considering roles age, season circadian rhythm. studies requiring level detail be done on humans, also review available evidence other animal species. For each timescales, identify or biological functions shaping variation. When possible, show evolutionary played a role, either directly regulate cancer risk indirectly through trade‐offs. We find varies with age more complex way than predicted by early epidemiological models: rather resulting from mutations alone, tumour development dictated tissue‐ age‐specific processes. Similarly, seasonal cycle can associated variation some species life‐history events such as sexual competition mating being timed according season. Lastly, influences tumourigenesis physiological, pathological therapeutic contexts. highlight two core variations across our three timescales: immunity metabolism. Finally, understanding entanglement between tumourigenic cycles constrained limited number for which have extensive data. Improving knowledge periods vulnerability onset and/or progression (malignant) tumours key issue deserves further investigation, successful prevention strategies.

Language: Английский

Citations

0