Corticolimbic structural connectivity encapsulates real-world emotional reactivity and happiness DOI Creative Commons
Mijin Kim,

Sunghyun Shin,

Mina Jyung

et al.

Social Cognitive and Affective Neuroscience, Journal Year: 2023, Volume and Issue: 18(1)

Published: Jan. 1, 2023

Abstract Emotional reactivity to everyday events predicts happiness, but the neural circuits underlying this relationship remain incompletely understood. Here, we combined experience sampling methods and diffusion magnetic resonance imaging examine association among corticolimbic structural connectivity, real-world emotional daily experiences of happiness from 79 young adults (35 females). Participants recorded momentary assessments five times a day for week, approximately 2 weeks after brain scanning. Model-based scores, which index degree moment-to-moment affective state varies with occurrence positive or negative events, were computed. Results showed that stronger microstructural integrity uncinate fasciculus external capsule was associated both greater scores. The between these fiber tracts experienced explained by reactivity. Importantly, indirect effect observed not events. Our findings suggest supporting socioemotional functions are in real world.

Language: Английский

The Amygdala and Depression: A Sober Reconsideration DOI
Shannon E. Grogans, Andrew S. Fox, Alexander J. Shackman

et al.

American Journal of Psychiatry, Journal Year: 2022, Volume and Issue: 179(7), P. 454 - 457

Published: July 1, 2022

Language: Английский

Citations

55
Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning DOI Creative Commons
Renée M. Visser, Joe Bathelt, H. Steven Scholte

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(50), P. 10278 - 10292

Published: Nov. 8, 2021

Most of our knowledge about human emotional memory comes from animal research. Based on this work, the amygdala is often labeled brain's “fear center”, but it unclear to what degree neural circuitries underlying fear and extinction learning are conserved across species. Neuroimaging studies in humans yield conflicting findings, with many failing show activation response learned threat. Such null findings treated as resulting MRI-specific problems related measuring deep brain structures. Here we test assumption a mega-analysis three acquisition ( n = 98; 68 female) 79; 53 female). The conditioning procedure involved presentation two pictures faces houses: one each pair was followed by an electric shock [a conditioned stimulus (CS + )], other never – ), participants were instructed learn these contingencies. Results revealed widespread responses CS compared network, including anterior insula, midcingulate cortex, thalamus, bed nucleus stria terminalis, not amygdala, which actually responded stronger . independent spatial smoothing, individual differences trait anxiety pupil responses. In contrast, robust distinguished houses, refuting idea that poor signal could account for absence effects. Moving forward, suggest that, apart imaging larger samples at higher resolution, alternative statistical approaches may be used identify cross-species similarities learning. SIGNIFICANCE STATEMENT science provides foundation numerous theories psychopathology, stress disorders. This field relies heavily research, suggests central role memory. However, finding strongly corroborated neuroimaging evidence humans, too easily explained away methodological limitations inherent large nonclinical sample, find BOLD fear, amygdala. A While do disprove involvement learning, they challenge its typical portrayals illustrate complexities translational science.

Language: Английский

Citations

46
The central extended amygdala guides survival-relevant tradeoffs: Implications for understanding common psychiatric disorders DOI Creative Commons
Daniel C. Holley,

Andrew S. Fox

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104879 - 104879

Published: Sept. 15, 2022

Language: Английский

Citations

20
Motivation and Pleasure Deficits Undermine the Benefits of Social Affiliation in Psychosis DOI
Jack J. Blanchard,

Jason F. Smith,

Melanie E. Bennett

et al.

Clinical Psychological Science, Journal Year: 2024, Volume and Issue: 12(6), P. 1195 - 1217

Published: Feb. 19, 2024

In psychotic disorders, motivation and pleasure (MAP) deficits are associated with decreased affiliation heightened functional impairment. We leveraged a transdiagnostic sample enriched for psychosis multi-method approach to test the hypothesis that MAP undermine stress-buffering benefits of affiliation. Participants completed Social Affiliation Enhancement Task (SAET) cultivate an experimental partner. Although SAET increased perceived mood, individuals greater negative symptoms derived smaller emotional from partners, as indexed by self-report facial behavior. then used Handholding fMRI paradigm, which combines threat-anticipation affiliative physical contact, determine whether social regulation distress. Individuals showed diminished neural 'benefits'-reduced dampening threat-elicited activation-from touch in key frontoparietal nodes Dorsal Attention Network. short, disrupt neuroregulatory

Language: Английский

Citations

4
Neuroticism modulates functional connectivity of the midcingulate cortex during emotional conflict DOI Creative Commons

H.Y. Kim,

Junhyun Park, Manuel Kuhn

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

Language: Английский

Citations

0
Unsupervised learning analysis of European working condition DOI Creative Commons
Olumide S. Adesina, Adedayo F. Adedotun,

Semiu Ayinla Alayande

et al.

Cogent Business & Management, Journal Year: 2024, Volume and Issue: 11(1)

Published: Feb. 24, 2024

Workers require good working conditions to enhance their job performance, in this study, we conducted a survey of European 2022 and compared the results with that 2016 using an unsupervised learning approach for exploratory data analysis determining relationships. Hence, Principal Component Analysis (PCA) was adopted. The analyses were two parts both surveys. Following PCA, first part shows workers are mostly characterized by cheerfulness spirits. second reveals best enthusiasm work. Test statistics showed condition periods does not differ significantly. Europe have been altered space six years. This study recommends should be improved so employers would continue give best.

Language: Английский

Citations

3
Spatiotemporal Dynamics of Stress-Induced Network Reconfigurations Reflect Negative Affectivity DOI
Anne Kühnel, Michael Czisch, Philipp G. Sämann

et al.

Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(2), P. 158 - 169

Published: Jan. 26, 2022

Language: Английский

Citations

13
Acute nicotine abstinence amplifies subjective withdrawal symptoms and threat-evoked fear and anxiety, but not extended amygdala reactivity DOI Creative Commons
Hyung Cho Kim, Claire M. Kaplan, Samiha Islam

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(7), P. e0288544 - e0288544

Published: July 20, 2023

Tobacco smoking imposes a staggering burden on public health, underscoring the urgency of developing deeper understanding processes that maintain addiction. Clinical and experience-sampling data highlight importance anxious withdrawal symptoms, but underlying neurobiology has remained elusive. Mechanistic work in animals implicates central extended amygdala (EAc)-including nucleus neighboring bed stria terminalis-but translational relevance these discoveries remains unexplored. Here we leveraged randomized trial design, well-established threat-anticipation paradigm, multidimensional battery assessments to understand consequences 24-hour nicotine abstinence. The paradigm had expected consequences, amplifying subjective distress arousal, recruiting canonical network. Abstinence increased urges potentiated threat-evoked distress, negligible for EAc threat reactivity, raising questions about prominent animal human models These observations provide framework conceptualizing abstinence withdrawal, with implications basic, translational, clinical science.

Language: Английский

Citations

7
Neuroticism/Negative Emotionality Is Associated with Increased Reactivity to Uncertain Threat in the Bed Nucleus of the Stria Terminalis, Not the Amygdala DOI
Shannon E. Grogans, Juyoen Hur, Matthew G. Barstead

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(32), P. e1868232024 - e1868232024

Published: July 15, 2024

Neuroticism/negative emotionality (N/NE)-the tendency to experience anxiety, fear, and other negative emotions-is a fundamental dimension of temperament with profound consequences for health, wealth, well-being. Elevated N/NE is associated panoply adverse outcomes, from reduced socioeconomic attainment psychiatric illness. Animal research suggests that reflects heightened reactivity uncertain threat in the bed nucleus stria terminalis (BST) central amygdala (Ce), but relevance these discoveries humans has remained unclear. Here we used novel combination psychometric, psychophysiological, neuroimaging approaches test this hypothesis an ethnoracially diverse, sex-balanced sample 220 emerging adults selectively recruited encompass broad spectrum N/NE. Cross-validated robust-regression analyses demonstrated preferentially BST activation during anticipation genuinely distressing (aversive multimodal stimulation), whereas was unrelated certain-threat anticipation, Ce either type or BST/Ce threat-related faces. It often assumed different paradigms are interchangeable assays individual differences brain function, yet rarely been tested. Our results revealed negligible associations between presentation faces, indicating two tasks nonfungible. These observations provide framework conceptualizing emotional traits disorders; guiding design interpretation biobank studies risk, disease, treatment; refining mechanistic research.

Language: Английский

Citations

2
Bad dream, nightmares and psychopathology: a systematic review DOI Creative Commons
Julie Faccini, Jonathan Del‐Monte

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Objective Bad dreams and nightmares can have a strong psychological impact. However, although the scientific literature points in direction of an established association between psychopathology, many studies investigating these links been carried out on general population. This systematic review aimed to identify that used sample from population with diagnosis psychopathological disorders or nightmare disorder, highlight state knowledge concerning link bad dreams, nightmares, psychopathology. Method The included all cross-sectional longitudinal conducted psychiatric which variables related and/or were examined published since 2014. search was May 2024 PsychINFO PubMed databases. Results A total 34 over last decade met inclusion criteria. Conclusions Psychiatric populations are significantly more affected by than Furthermore, presence tends maximize clinical symptomatology patients. there still too few available understand basis this relationship.

Language: Английский

Citations

2