The effect of geraniol on nickel-induced embryotoxicity and cardiotoxicity in rats DOI Creative Commons
Ali Tavakoli Pirzaman,

Ghazaleh Sadeghnezhad,

Zahra Azmoun

et al.

International Journal of Immunopathology and Pharmacology, Journal Year: 2024, Volume and Issue: 38

Published: Jan. 1, 2024

Background Nickel (Ni), commonly-used heavy metals in industrial activities, can lead to embryo and organ toxicity, especially cardiovascular damage. Geraniol (GER) has various beneficial effects such as anti-oxidant, anti-inflammatory, anti-tumor, anti-ulcer, anti-microbial, neuroprotective activities. Objective The objective of this study was investigate the effect GER on Ni-induced embryotoxicity cardiotoxicity rats. Methods 40 mother Wistar rats were randomly divided into five groups: Control, 250, Ni, Ni + 100, 250. On 20 th day pregnancy, animals sacrificed fetuses along with blood tissue samples collocated for morphological, serological, biochemical, histopathologic analysis. Results Morphological assessments revealed GER’s capacity mitigate incomplete ossification fetal skeletons, indicating a potential safeguarding against impact embryotoxicity. Serological biochemical analyses further affirm role, noteworthy reductions cardiac injury markers, CRP, CKMB, CPK, LDH, troponin, response administration, thereby suggesting its cardioprotective potential. Moreover, treatment 250 could significantly reduce level MDA increase TAC compared group. Histopathological examinations corroborated these findings, underscoring ability counteract diminish structural damage affected tissue. Conclusions These multidimensional indicate protective prowess embryotoxic cardiotoxic effects, shedding light therapeutic significance combating adverse impacts stemming from exposure.

Language: Английский

Toxicity Tolerance in the Carcinogenesis of Environmental Cadmium DOI Open Access
Aleksandar Ćirović,

Soisungwan Satarug

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1851 - 1851

Published: Feb. 3, 2024

Cadmium (Cd) is an environmental toxicant of worldwide public health significance. Diet the main non-workplace Cd exposure source other than passive and active smoking. The intestinal absorption involves transporters for essential metals, notably iron zinc. These determine body burden because only a minuscule amount can be excreted each day. International Agency Research on Cancer listed as human lung carcinogen, but current evidence suggests that effects cancer risk extend beyond lung. A two-year bioassay demonstrated caused neoplasms in multiple tissues mice. Also, several non-tumorigenic cells transformed to malignant when they were exposed sublethal dose prolonged time. does not directly damage DNA, it influences gene expression through interactions with metals various proteins. present review highlights epidemiological studies connect enhanced neoplastic diseases chronic Cd. Special emphasis given impact stores Cd, its implications breast prevention highly susceptible groups women. Resistance cell death phenotypes acquired during Cd-induced transformation, under vitro conditions, are briefly discussed. potential role ZnT1 efflux transporter cellular acquisition tolerance cytotoxicity highlighted.

Language: Английский

Citations

16
Melatonin Interplay in Physiology and Disease—The Fountain of Eternal Youth Revisited DOI Creative Commons
Cándido Ortiz-Placín, Ginés M. Salido, Antonio González

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 682 - 682

Published: May 8, 2025

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone associated with the regulation of biological rhythms. The indoleamine secreted by pineal gland during night, following circadian rhythm. highest plasmatic levels are reached whereas lowest achieved day. In addition to gland, other organs and tissues also produce melatonin, like, for example, retina, Harderian glands, gut, ovaries, testes, skin, leukocytes, or bone marrow. list extensive, including cerebellum, airway epithelium, liver, kidney, adrenals, thymus, thyroid, pancreas, carotid body, placenta, endometrium. At all these locations, availability melatonin intended local use. Interestingly, decline amplitude secretion occurs in old subjects comparison that found younger subjects. Moreover, genetic environmental factors primary causes diseases, oxidative stress key contributor most pathologies. Numerous studies exist show interesting effects different models disease. Impairment its might have deleterious consequences cellular physiology. this regard, natural compound carrier not yet completely known potential deserves consideration. Thus, has emerged as helpful ally could be considered guard powerful tools orchestrate homeostasis majorly based on antioxidant effects. review, we provide an overview widespread actions against diseases preferentially affecting elderly.

Language: Английский

Citations

0
Melatonin mitigates vincristine-induced peripheral neuropathy by inhibiting TNF-α/astrocytes/microglial cells activation in the spinal cord of rats, while preserving vincristine's chemotherapeutic efficacy in lymphoma cells DOI
Engie S. El-Sawaf,

Nabila N. El Maraghy,

Hanan S. El‐Abhar

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 492, P. 117134 - 117134

Published: Oct. 25, 2024

Language: Английский

Citations

1
The effect of geraniol on nickel-induced embryotoxicity and cardiotoxicity in rats DOI Creative Commons
Ali Tavakoli Pirzaman,

Ghazaleh Sadeghnezhad,

Zahra Azmoun

et al.

International Journal of Immunopathology and Pharmacology, Journal Year: 2024, Volume and Issue: 38

Published: Jan. 1, 2024

Background Nickel (Ni), commonly-used heavy metals in industrial activities, can lead to embryo and organ toxicity, especially cardiovascular damage. Geraniol (GER) has various beneficial effects such as anti-oxidant, anti-inflammatory, anti-tumor, anti-ulcer, anti-microbial, neuroprotective activities. Objective The objective of this study was investigate the effect GER on Ni-induced embryotoxicity cardiotoxicity rats. Methods 40 mother Wistar rats were randomly divided into five groups: Control, 250, Ni, Ni + 100, 250. On 20 th day pregnancy, animals sacrificed fetuses along with blood tissue samples collocated for morphological, serological, biochemical, histopathologic analysis. Results Morphological assessments revealed GER’s capacity mitigate incomplete ossification fetal skeletons, indicating a potential safeguarding against impact embryotoxicity. Serological biochemical analyses further affirm role, noteworthy reductions cardiac injury markers, CRP, CKMB, CPK, LDH, troponin, response administration, thereby suggesting its cardioprotective potential. Moreover, treatment 250 could significantly reduce level MDA increase TAC compared group. Histopathological examinations corroborated these findings, underscoring ability counteract diminish structural damage affected tissue. Conclusions These multidimensional indicate protective prowess embryotoxic cardiotoxic effects, shedding light therapeutic significance combating adverse impacts stemming from exposure.

Language: Английский

Citations

0