Research advancements in the association between prevalent trace metals and connective tissue diseases DOI
Jie Chang, Qian Wu, Gang Wang

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 47(1)

Published: Dec. 14, 2024

Language: Английский

Cuproposis-Related Gene LIAS: Disease Mechanism and New Therapeutic Directions DOI

琳 吴

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 621 - 628

Published: Jan. 1, 2025

Language: Английский

Citations

0
Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets DOI Creative Commons

Shen’er Qian,

Yao Long, Guolin Tan

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Programmed cell death represents a precisely regulated and active cellular demise, governed by complex network of specific genes proteins. The identification multiple forms programmed has significantly advanced the understanding its intricate mechanisms, as demonstrated in recent studies. A thorough grasp these processes is essential across various biological disciplines study diseases. Nonetheless, despite notable progress, exploration relationship between disease, well clinical application, are still nascent stage. Therefore, further development corresponding therapeutic methods strategies holds substantial potential. Our review provides detailed examination primary mechanisms behind apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis. Following this, discussion delves into functions diseases associated dysregulated death. Finally, we highlight existing potential targets focused on cancers neurodegenerative This aims to summarize latest insights from more reliable approach for transformation.

Language: Английский

Citations

2
Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma DOI Creative Commons
Zhifei Che, Wenyi Jin, Yaoxi Wu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 7, 2024

The crosstalk between cuproptosis and the tumor immune microenvironment (TIME) is vital during clear cell renal carcinoma (ccRCC) malignant progression. However, underlying molecular mechanisms regulate this cross-talk remain elusive. Through tailored machine learning, we analyze clinical ccRCC data from Cancer Genome Atlas (TCGA) to explore critical factors that interaction among cuproptosis, TIME, We found rhomboid-like 2 (RHBDL2), gene affecting process, might inhibit cuproptosis-related genes (CRGs) promotes progression through Wnt/β-catenin pathway. Next, knocking down RHBDL2 expression increased ferredoxin 1 (FDX1) lipoic acid synthase (LIAS) levels but reduced forkhead box P3 (FOXP3) growth in vivo vitro models. By employing HLY78, pathway activator, rescued of CRGs proliferation metastasis capacity cells with knockdown. Mechanistically, inhibits Abnormal may cause suppressive TIME formation by regulating Treg-cell infiltration, thus triggering escape. In summary, our results indicated an oncogene induces tumorigenesis targeting be novel therapeutic direction for metastatic ccRCC.

Language: Английский

Citations

0
Research advancements in the association between prevalent trace metals and connective tissue diseases DOI
Jie Chang, Qian Wu, Gang Wang

et al.

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 47(1)

Published: Dec. 14, 2024

Language: Английский

Citations

0