Stem Cell Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102507 - 102507
Published: May 1, 2025
The
human
brain
has
a
very
limited
capacity
for
self-repair,
presenting
significant
challenges
in
recovery
following
injuries
such
as
ischemic
stroke.
Stem
cell-based
therapies
have
emerged
promising
strategies
to
enhance
post-stroke
recovery.
Building
on
large
body
of
preclinical
evidence,
clinical
trials
are
currently
ongoing
prove
the
efficacy
stem
cell
therapy
stroke
patients.
However,
mechanisms
through
which
grafts
promote
neural
repair
remain
incompletely
understood.
Key
questions
include
whether
these
effects
primarily
driven
by
(1)
secretion
trophic
factors
that
stimulate
endogenous
processes,
(2)
direct
replacement,
or
(3)
combination
both
mechanisms.
This
review
explores
latest
advancements
stroke,
highlighting
research
insights
Deciphering
fundamental
underlying
cell-mediated
regeneration
holds
potential
refine
therapeutic
and
advance
treatments
range
neurological
disorders.
Stem Cell Reviews and Reports,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 21, 2025
One
of
the
major
global
causes
death
and
disability
is
ischemic
stroke
(IS).
Mesenchymal
stem
cells
(MSCs)
emerge
as
a
cell-based
therapy
for
numerous
diseases.
Recently,
research
on
role
MSCs
in
has
developed
rapidly
worldwide.
Bibliometric
analysis
IS
not
yet
been
published,
though.
Through
bibliometric
analysis,
aim
this
study
was
to
assess
current
state
field
worldwide
identify
important
results,
areas,
emerging
trends.
Publications
related
from
January
1,
2002,
December
31,
2022,
were
obtained
Web
Science
Core
Collection
(WoSCC).
We
used
HistCite,
VOSViewer,
CiteSpace,
Bibliometrix
visualization.
employed
Total
Global
Citation
Score
(TGCS)
impact
publications.
The
included
total
2,048
1,386
papers
authored
by
200
individuals
across
organizations
72
countries,
published
202
journals.
Cesar
V
Borlongan
most
documents
among
high-productivity
authors.
Michael
Chopp
author
with
highest
average
number
citations
per
paper,
an
paper
citation
time
118.54.
found
that
starting
2008.
Neurosciences
productive
journals,
Chinese
researchers
have
produced
subject.
cited
article
"Systemic
administration
exosomes
released
mesenchymal
stromal
promotes
functional
recovery
neurovascular
plasticity
after
rats".
This
uses
both
numbers
descriptions
thoroughly
review
IS.
information
provides
valuable
experience
carry
out
MSCs'
work
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(4), P. e0321579 - e0321579
Published: April 21, 2025
Corneal
diseases
are
a
leading
cause
of
visual
impairment,
and
their
treatment
remains
challenging.
epithelial
stem
cells
exist
in
the
limbus,
peripheral
region
cornea,
play
an
important
role
corneal
regeneration.
Here,
we
evaluated
effects
extracellular
vesicles
from
human
adipose-derived
mesenchymal
(AdMSC-EVs)
on
limbal
(LECs).
Colony
formation
assays
showed
that
colony-forming
efficiency
LECs
significantly
increased
presence
AdMSC-EVs.
We
next
demonstrated
AdMSC-EVs
accelerated
migration
scratch
assay,
whereas
proliferation
was
decreased
by
cell
assay.
RNA
sequencing
analysis
indicated
maintained
properties
improved
epithelial-mesenchymal
transition
(EMT).
Furthermore,
after
identifying
six
most
abundant
microRNAs
(miRNAs)
AdMSC-EVs,
LEC
transfection
with
miRNA
mimics
miR-25
,
miR-191
miR-335
were
probable
factors
within
at
improving
colony
ability
EMT.
Taken
together,
our
findings
enhanced
EMT
LECs,
in-part
mediated
miRNAs
Tzu Chi Medical Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 9, 2025
A
BSTRACT
Objectives:
Transplantation
of
human
umbilical
cord
blood
cells
(hUCB)
may
enhance
neuroprotection,
and
thus,
the
intravenous
(IV)
infusion
hUCB
in
patients
with
acute
ischemic
stroke
(AIS)
is
being
tested
for
its
safety
efficacy.
Materials
Methods:
We
conducted
a
12-month,
open-label,
single-center,
phase
I
trial
treatment
AIS
at
age
45–80
years,
magnetic
resonance
imaging
evidence
infarction
internal
carotid
artery
supplied
territory
National
Institute
Health
Stroke
Scale
(NIHSS)
score
between
6
18.
Eligible
participants
received
single-dose
IV
followed
by
two
doses
mannitol
within
9
days
after
onset
symptoms.
The
primary
endpoint
was
incidence
adverse
events
(AEs)
secondary
endpoints
were
changes
NIHSS,
Barthel
index
(BI),
Berg
Balance
(BBS)
scores.
Results:
Six
(Male:
Female
=
3:
3)
enrolled
mean
65.8
years.
total
40
AEs
occurred
six
during
this
study,
which
included
nine
serious
events.
Only
transient
erythema
multiforme
hematuria
probably
possibly
related
to
infusion,
respectively.
NIHSS
11.5
baseline
it
significantly
improved
1,
3,
6,
9,
12
months
(mean
change
from
baseline:
−4.0,
−5.3,
−6.8,
−7.0,
−7.3).
BI
22.5
increased
3
26.7
42.5,
respectively).
BBS
numerically
but
did
not
reach
statistical
significance.
cytokine
levels
spleen
size
unremarkable.
Conclusion:
safe
well
tolerated
patients,
preliminary
efficacy
results
demonstrated
therapeutic
potential,
supporting
conduct
randomized,
placebo
controlled,
II
clinical
future.
Stem Cell Reports,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102507 - 102507
Published: May 1, 2025
The
human
brain
has
a
very
limited
capacity
for
self-repair,
presenting
significant
challenges
in
recovery
following
injuries
such
as
ischemic
stroke.
Stem
cell-based
therapies
have
emerged
promising
strategies
to
enhance
post-stroke
recovery.
Building
on
large
body
of
preclinical
evidence,
clinical
trials
are
currently
ongoing
prove
the
efficacy
stem
cell
therapy
stroke
patients.
However,
mechanisms
through
which
grafts
promote
neural
repair
remain
incompletely
understood.
Key
questions
include
whether
these
effects
primarily
driven
by
(1)
secretion
trophic
factors
that
stimulate
endogenous
processes,
(2)
direct
replacement,
or
(3)
combination
both
mechanisms.
This
review
explores
latest
advancements
stroke,
highlighting
research
insights
Deciphering
fundamental
underlying
cell-mediated
regeneration
holds
potential
refine
therapeutic
and
advance
treatments
range
neurological
disorders.
