Pharmacovigilance in Action: Utilizing VigiBase Data to Improve Clozapine Safety DOI Creative Commons
Carlos De las Cuevas, Emílio J. Sanz, José de León

et al.

Patient Preference and Adherence, Journal Year: 2024, Volume and Issue: Volume 18, P. 2261 - 2280

Published: Nov. 1, 2024

Clozapine is an antipsychotic which was approved in 1989 for treatment-resistant schizophrenia the United States (US). There were few randomized trials before its approval and potentially lethal clozapine adverse drug reactions (ADRs), such as agranulocytosis myocarditis identified by pharmacovigilance. VigiBase, WHO global database, a cornerstone of international pharmacovigilance efforts ADR identification during post-marketing surveillance. This systematic review literature explores additional contributions to knowledge ADRs from recent VigiBase studies.

Language: Английский

Pharmacovigilance in Action: Utilizing VigiBase Data to Improve Clozapine Safety DOI Creative Commons
Carlos De las Cuevas, Emílio J. Sanz, José de León

et al.

Patient Preference and Adherence, Journal Year: 2024, Volume and Issue: Volume 18, P. 2261 - 2280

Published: Nov. 1, 2024

Clozapine is an antipsychotic which was approved in 1989 for treatment-resistant schizophrenia the United States (US). There were few randomized trials before its approval and potentially lethal clozapine adverse drug reactions (ADRs), such as agranulocytosis myocarditis identified by pharmacovigilance. VigiBase, WHO global database, a cornerstone of international pharmacovigilance efforts ADR identification during post-marketing surveillance. This systematic review literature explores additional contributions to knowledge ADRs from recent VigiBase studies.

Language: Английский

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