Current Pharmaceutical Design,
Journal Year:
2022,
Volume and Issue:
28(39), P. 3225 - 3230
Published: Oct. 21, 2022
Background:
Coronavirus
Disease-19
(COVID-19)
is
implicated
in
endotheliitis
which
adversely
affects
cardiovascular
events.
The
impact
of
vaccination
with
COVID-19
on
the
clinical
outcome
patients
documented.
Objective:
To
evaluate
severe
acute
respiratory
syndrome,
coronavirus-2
(SARS-CoV-2)
infection-related
endothelial
impairment.
Methods:
We
enrolled
45
hospitalized
for
(either
vaccinated
or
not
against
SARS-CoV-2).
Clinical
and
laboratory
data
were
collected,
brachial
artery
flow-mediated
dilation
(FMD)
was
evaluated.
Subjects
without
used
as
control
group.
Results:
There
no
difference
age
(64.7±7.5
years
vs.
61.2±11.1
62.4±9.5,
p=0.28)
male
sex
(49%
60%
52%,
p=0.71),
between
subjects,
vaccinated,
unvaccinated
subjects
respectively.
Of
COVID-19,
44%
SARS-CoV-2.
Unvaccinated
had
significantly
impaired
FMD
compared
to
Control
(2.05±2.41
%
7.24±2.52
7.36±2.94
%,
p<0.001).
Importantly,
post
hoc
tests
revealed
that
from
both
Vaccinated
(p<0.001)
form
(p<0.001).
group
(p=0.99).
Conclusion:
Hospitalized
present
dysfunction
phase
disease.
Endothelial
function
well
COVID-19.
do
show
dysfunction,
strengthening
protective
role
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
150, P. 112970 - 112970
Published: April 15, 2022
The
coronavirus
disease
2019
(COVID-19),
caused
by
the
SARS-CoV-2
virus,
is
a
current
pandemic
that
has
resulted
in
nearly
250
million
cases
and
over
5
deaths.
While
vaccines
have
been
developed
to
prevent
infection,
most
COVID-19
end
up
being
fairly
light,
there
are
severe
of
may
death,
even
with
adequate
healthcare
treatment.
New
options
combat
this
disease's
effects,
therefore,
could
prove
be
invaluable
saving
lives.
Adamalysins
proteins
several
roles
regulating
different
functions
human
body
but
also
known
inflammation.
They
diseases,
including
COVID-19,
where
ADAM17,
particular,
now
well-known
prominent
role,
diseases
which
include
comorbidities
worsen
COVID-19.
Therefore,
investigating
adamalysins
give
us
clues
molecular
workings
as
well
potentially
new
therapeutic
targets.
Understanding
these
mechanisms
allow
for
an
understanding
behind
rare
side
effects
occur
response
vaccines,
lead
better
monitoring
measures
people
who
more
at
risk
developing
effects.
This
review
investigates
disease,
what
currently
their
involvement
how
might
involved.
Internal Medicine,
Journal Year:
2021,
Volume and Issue:
61(1), P. 81 - 86
Published: Oct. 25, 2021
A
65-year-old
man
experienced
cough
and
shortness
of
breath
3
days
after
receiving
the
first
dose
Pfizer-BioNTech
coronavirus
disease
2019
(COVID-19)
vaccine.
Chest
X-ray
revealed
bilateral
infiltrates,
desaturation
deteriorated
rapidly.
The
symptoms
radiographic
abnormalities
rapidly
improved
initiation
corticosteroid
therapy.
Intradermal
testing
COVID-19
vaccine
showed
a
delayed
positive
reaction.
Based
on
these
findings,
patient
was
diagnosed
with
vaccine-induced
pneumonitis.
timing
onset
pneumonitis
vaccination
results
intradermal
suggest
that
Type
IV
hypersensitivity
against
may
have
been
responsible
for
this
clinical
condition.
Osong Public Health and Research Perspectives,
Journal Year:
2022,
Volume and Issue:
13(6), P. 394 - 406
Published: Nov. 28, 2022
The
recent
outbreak
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
ahighly
transmissible
virus
with
a
likely
animal
origin,
has
posed
major
and
unprecedentedchallenges
to
millions
lives
across
the
affected
nations
world.
This
firstoccurred
in
China,
despite
massive
regional
global
attempts
shortly
thereafter,
itspread
other
countries
caused
deaths
worldwide.
review
presents
keyinformation
about
characteristics
SARS-CoV-2
its
associated
disease
(namely,coronavirus
2019)
briefly
discusses
origin
virus.
Herein,
we
also
brieflysummarize
strategies
used
against
viral
spread
transmission.
Clinical Case Reports,
Journal Year:
2023,
Volume and Issue:
11(4)
Published: March 31, 2023
Abstract
The
presence
and
reactivation
of
oral
lesions
such
as
herpetic
gingivostomatitis,
erythema
multiforme,
candidiasis
in
a
COVID‐19
recovered
patient
could
be
related
to
COVID‐19s
profound
role
immune
dysregulation
or
therapies.
Medicina,
Journal Year:
2021,
Volume and Issue:
57(10), P. 997 - 997
Published: Sept. 22, 2021
SARS-CoV-2
induced
a
pandemic
that
is
reported
to
have
started
in
Asia
and
was
then
extended
other
countries
the
world.
Main
clinical
aspects
of
this
viral
infection
been
lung
injuries
with
severe
pneumonia
requiring
prolonged
hospitalization
associated
morbidities
such
as
venous
thromboembolism
and/or
superinfection
by
bacteria,
fungus
or
pests.
Immediately
there
need
develop
sustainable
therapeutic
strategy,
vaccination.
Vaccines
against
Covid-19,
fact,
exert
protective
action
for
common
people
reduce
diffusion.
Yet,
vaccination
large
number
raises
question
well-known
complication
several
types
vaccines;
immune
thrombocytopenia,
which
sometimes
thrombosis
well.
In
short
review,
we
summarized
mechanisms
involved
pathogenesis
vaccine-induced
prothrombotic
thrombocytopenia
thrombocytopenic
thrombosis.
Journal of Clinical Laboratory Analysis,
Journal Year:
2022,
Volume and Issue:
36(12)
Published: Nov. 28, 2022
Abstract
Background
The
severe
acute
respiratory
syndrome
coronavirus
2
Omicron
variant
has
a
low
rate
of
serious
illness,
is
highly
contagious,
and
spread
rapidly
since
January
2022.
number
cases
deaths
remains
problematic.
Here,
we
aimed
to
elucidate
the
coagulation
pathology
Omicron‐infected
patients
using
rotational
thromboelastometry.
Methods
Patients
with
disease
2019,
hospitalized
treated
from
2021
April
2022,
were
included.
Alpha–Delta
groups
defined
during
admission.
Blood
tests,
clinical
course,
thromboelastometry
measurements
compared
propensity
score‐matched
cohort.
Results
Both
had
21
each.
Lactate
dehydrogenase
(Alpha–Delta
group
[interquartile
range]
vs.
range];
449
[368–518]
U/L
241
[196–398]
U/L,
p
=
0.01)
ferritin
(1428
[1145–3061]
ng/dl
481
[188–881]
ng/dl,
0.0002)
levels
significantly
lower
in
group.
In
thromboelastometry,
thrombus
hardness
indexes
FIBTEM
A5
(29
[23–34]
mm
23
[18–28]
mm,
0.034)
maximum
clot
firmness
(34
[27–40]
26
[21–33]
0.021)
group,
whereas
fibrinolysis
index
LI60
(98
[92–100]
%
100
[100–100]
%,
0.0082)
was
higher.
Conclusion
Severe
abnormalities
may
be
less
likely
than
those
infected
previous
Alpha
Delta
variants.
International Heart Journal,
Journal Year:
2022,
Volume and Issue:
63(2), P. 388 - 392
Published: March 29, 2022
CoronaVac
is
an
inactivated
coronavirus
disease
(COVID-19)
vaccine
that
was
granted
emergency
authorization
by
the
World
Health
Organization
in
June
2021.
We
present
two
cases
of
patients
presenting
with
chest
pain,
abnormal
electrocardiography,
and
elevated
troponin
consistent
non-ST-elevation
myocardial
infarction
within
24
hours
after
receiving
COVID-19
vaccine.
Hematology Reports,
Journal Year:
2022,
Volume and Issue:
14(4), P. 358 - 372
Published: Dec. 1, 2022
Adenoviral-based
vaccines
such
as
ChadoX1
CoV-19
(AstraZeneca)
and
Ad26.COV2.S
(J&J)
were
developed
to
prevent
infection
reduce
hospitalization
or
death
in
Coronavirus
Disease
2019
(COVID-19)
patients.
Although
these
passed
safety
efficacy
trials
with
excellent
neutralizing
capabilities
against
SARS-CoV-2,
very
rare
reports
of
acute
thrombotic
thrombocytopenic
events
following
administration
emerged
certain
populations,
which
triggered
a
series
clinical
investigations
that
gave
rise
novel
phenomenon
called
vaccine-induced
immune
thrombocytopenia
(VITT).
Several
converging
pathways
exist
between
VITT
other
forms
syndromes,
specifically
heparin-induced
thrombocytopenia,
involves
the
formation
anti-PF4
antibodies
activation
platelets
leading
thrombin-mediated
clotting.
Interestingly,
differences
presentation
also
VITT,
guidelines
have
been
published
recent
months
assist
clinicians
recognizing
achieve
desired
outcomes.
In
this
paper,
we
first
discuss
clotting
COVID-19
delineate
it
from
followed
by
review
current
knowledge
on
manifestations
lieu
syndromes.
Likewise,
emerging
evidence
role
adenoviral
vectors
vaccine
constituents
is
discussed
briefly.
