Neural markers of methylphenidate response in children with attention deficit hyperactivity disorder and the impact on executive function DOI Creative Commons
Anqi Wang, Hua Yang,

Yue Yang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Background Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. A core cognitive deficit in ADHD executive function (EF) impairment, which significantly impacts daily life. Methylphenidate (MPH) widely used first-line treatment for ADHD, but objective biomarkers to assess response are lacking. The aim of this study was investigate the effects MPH on identify potential neural children with using electroencephalogram (EEG). Methods total 26 boys (mean age 8.64 ± 1.30 years) participated study. All participants were treated 18 mg/day oral extended-release morning 8 weeks. Executive assessed BRIEF2 Digit Span Test (DST), event-related potentials (ERP) measured at baseline after weeks treatment. Results After treatment, significant improvements observed several domains. scores, including inhibition, self-monitoring, shifting, emotional control, initiation, working memory, planning/organization, task monitoring, material organization, reduced ( P < 0.05). Behavioral performance Go/NoGo also improved, shorter correct times higher accuracy rates = 0.002, 0.009). EEG results revealed reduction Nogo-P300 latency Fz, Cz Pz compared <0.05). Conclusions normalization P300 following appears be reliable biomarker positive ADHD. associated function, particularly inhibitory control memory.

Language: Английский

Neural markers of methylphenidate response in children with attention deficit hyperactivity disorder and the impact on executive function DOI Creative Commons
Anqi Wang, Hua Yang,

Yue Yang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Background Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. A core cognitive deficit in ADHD executive function (EF) impairment, which significantly impacts daily life. Methylphenidate (MPH) widely used first-line treatment for ADHD, but objective biomarkers to assess response are lacking. The aim of this study was investigate the effects MPH on identify potential neural children with using electroencephalogram (EEG). Methods total 26 boys (mean age 8.64 ± 1.30 years) participated study. All participants were treated 18 mg/day oral extended-release morning 8 weeks. Executive assessed BRIEF2 Digit Span Test (DST), event-related potentials (ERP) measured at baseline after weeks treatment. Results After treatment, significant improvements observed several domains. scores, including inhibition, self-monitoring, shifting, emotional control, initiation, working memory, planning/organization, task monitoring, material organization, reduced ( P < 0.05). Behavioral performance Go/NoGo also improved, shorter correct times higher accuracy rates = 0.002, 0.009). EEG results revealed reduction Nogo-P300 latency Fz, Cz Pz compared <0.05). Conclusions normalization P300 following appears be reliable biomarker positive ADHD. associated function, particularly inhibitory control memory.

Language: Английский

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