Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 8, 2024

Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, treatment PCOS mainly based on symptoms and not its pathophysiology. Neuroendocrine disturbance, as shown by an elevated LH/FSH ratio in patients, was thought to be central mechanism syndrome, especially lean PCOS. LH FSH secretion are influenced GnRH pulsatility neurons hypothalamus. Kisspeptin main regulator secretion, whereas neurokinin B (NKB) dynorphin regulate kisspeptin KNDy neurons. This study aims deepen understanding neuroendocrine patients potential pathophysiology-based therapy. A cross-sectional performed at Dr. Cipto Mangunkusumo Kencana Hospital IMERI UI HRIFP cluster with 110 subjects. LH, FSH, ratio, kisspeptin, NKB, dynorphin, leptin, adiponectin, AMH, fasting blood glucose, insulin, HOMA-IR, testosterone, SHBG were measured. Bivariate path analyses determine relationship between variables. There a negative association while NKB levels associated kisspeptin. no direct ratio; interestingly, positively both bivariate pathway analyses. AMH correlated Path analysis showed PCOS, Furthermore, there correlation but did show significant ratio. HOMA-IR negatively adiponectin leptin FAI levels. In conclusion, correlates directly showing important role neuroendocrinology From analysis, also intermediary variable Interestingly, this found positive found. Further research needed investigate therapeutic targets management patients.

Language: Английский

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Ameliorative effect of Fagonia indica-coated chitosan nanoparticles on the ovulatory pattern in PCOS rat model

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 6, 2025

Polycystic ovarian syndrome (PCOS) with wide-range prevalence, affecting 5-18% of females reproductive age, and its substantive role as a primary etiological factor in anovulatory infertility, up to 80% such cases attributed this having particular significance. The current research delineates the outcomes meticulous inquiry into efficacy Fagonia indica-coated chitosan nanoparticles (FICNPs) ameliorating prevalent clinically consequential PCOS female Wistar rats. FICNPs were synthesized by using methanolic extract F. indica via ion gelatin method. nuanced interplay hormonal profiles, histology, miRNA expression response intervention was investigated. Notable findings include an obvious decrease luteinizing (LH) testosterone hormone levels high-dose FICNPs-treated subjects (100 mg/kg) compared their untreated counterparts. Follicle-stimulating (FSH) prolactin markedly decreased rat models, whereas, histopathological examination revealed augmented oocyte diameters FICNP-treated rats, suggesting pronounced improvements morphogenesis follicular maturation. Additionally, real-time quantitative PCR analysis disparate prominently implicating rno-miR-30c-2-3p, rno-miR-146b-5p, rno-miR-486, rno-miR-3586-3p therapeutic FICNPs. Notably, progeny (F1 generation) showed normalized ovulatory activity, substantiating sustained potential Collectively, these underscore auspicious promise paradigm-shifting modality for mitigating complex pathophysiology PCOS, thereby addressing formidable prevalence clinical import, surpass conventional pharmacotherapy modalities.

Language: Английский

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Competence of Combined Low Dose of Human Chorionic Gonadotropin (HCG) and Clomiphene Citrate (CC) Versus Continued CC during Ovulation Induction in Women with CC-Resistant Polycystic Ovarian Syndrome: A Randomized Controlled Trial

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1300 - 1300

Published: Aug. 12, 2024

Background and Objectives: Polycystic ovarian syndrome (PCOS) is a widespread endocrine disorder affecting 5–18% of females in their childbearing age. The aim this study to assess the efficacy combining low dosage human chorionic gonadotropin (HCG) along with clomiphene citrate (CC) for stimulating ovulation infertile women diagnosed CC-resistant PCOS. Materials Methods: A randomized controlled trial was carried out on 300 PCOS women. All participants were assigned two groups: CC-HCG group CC-Placebo group. Subjects given CC (150 mg/day 5 days starting 2nd day cycle) HCG (200 IU/day SC 7th cycle). placebo. number follicles > 18 mm, cycle cancellation rate, endometrial thickness, clinical pregnancy occurrence early hyper-stimulation all outcome variables primary research. Results: Data from 138 individuals 131 subjected final analysis. In comparison group, rate considerably lower. exhibited substantial increase reaching rate. higher (7.2% vs. 2.3%; CC-Placebo). Upon adjusting BMI age, findings our revealed that who had serum prolactin levels below 20 (ng/mL), secondary infertility, infertility duration less than 4 years, baseline LH/FSH ratios 1.5, AMH more (ng/mL) likelihood achieving pregnancy. there greater prediction those (<4), ≤ < years. Conclusions: use small dose appeared be an effective treatment reducing cancelation, improving patients. registered Clinical Trials.gov, identifier NCT02436226

Language: Английский

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Multisystem Health Consequences of Prenatal Hyperandrogenism in Offspring

Clinical and Experimental Obstetrics & Gynecology, Journal Year: 2024, Volume and Issue: 51(10)

Published: Oct. 8, 2024

Objective: Prenatal hyperandrogenism, characterized by elevated androgen levels during pregnancy, has significant multisystem impacts on offspring health. This review systematically examines the effects of prenatal hyperandrogenism cardiovascular, metabolic, reproductive, and behavioral health offspring. By analyzing existing research, this aims to provide a comprehensive understanding long-term offering insights for clinical management prevention related diseases. Mechanism: A search was performed in PubMed database with key words: “hyperandrogenemia child”, offspring”, “androgen excess “prenatal hyperandrogenism”, excess”, combination these terms find quality articles published from 1995 2024. Findings Brief: Elevated disrupt normal fetal development, leading consequences such as cardiovascular dysfunction, including hypertension cardiac hypertrophy, metabolic abnormalities insulin resistance syndrome. It impact offspring’s reproductive system, potential links conditions polycystic ovary syndrome (PCOS). Furthermore, is associated increased risks neuropsychiatric disorders, autism spectrum disorder (ASD) anxiety. Conclusions: disorders. The underlying mechanisms involve hormonal regulation, placental function, oxidative stress, gene expression alterations, programming. Further research needed develop effective interventions mitigate adverse effects.

Language: Английский

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