How Hormonal Balance Changes Lives in Women with Psoriasis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 582 - 582

Published: Jan. 17, 2025

Psoriasis is a chronic, immune-mediated skin disease significantly impacting women, with severity often modulated by hormonal fluctuations. This review examines the influence of changes on course psoriasis in focusing key life stages—including menstrual cycle, pregnancy, postpartum, and menopause—and their impact progression symptomatology. Estrogen, principal female sex hormone, plays critical role immune modulation. Variations estrogen levels, which occur naturally throughout woman’s life, are associated fluctuations severity. Low as seen during menstruation or menopause, linked to symptom exacerbation, while elevated levels pregnancy may reduce symptoms some women. However, responses variable, others experiencing no change worsening pregnancy. Postpartum, rapid decline triggers severe flare-ups, marked sustained reduction, frequently correlates increased flare frequency. The also addresses profound women’s quality including physical discomfort, psychological distress, social stigma. Additionally, fertility concerns discussed, treatments increase risk adverse outcomes. Consideration given therapies, lifestyle modifications, effects psoriasis, underscoring need for personalized treatment approaches that account influences. Understanding these dynamics essential developing targeted, effective management strategies enhance women affected psoriasis.

Language: Английский

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Case Report: Baricitinib improved alopecia areata in a pediatric patient with atopic dermatitis

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 10, 2025

Alopecia areata (AA) is a common non-scarring hair loss condition whose specific pathogenesis not yet fully understood. In children, AA often co-occurs with atopic dermatitis (AD), complicating treatment. Here, we report the case of child myasthenia gravis who had severe and moderate AD. The previously been treated local injections corticosteroids developed total AD after discontinuing corticosteroid use. After approximately one year treatment baricitinib, 4 mg once daily, combined twice-daily application ointment, significant improvement in child's was observed, Severity Tool score dropping from 100 to 24.4 Eczema Area Index 0. New vellus hairs were clearly observable under trichoscopy, which contrasted significantly pre-treatment state. Throughout process, patient's clinical symptoms, blood cell counts, liver kidney function, coagulation functions essentially normal, no adverse reactions observed except for folliculitis on scalp. We discuss targets as well safety prospects Janus kinase inhibitors pediatric patients these conditions.

Language: Английский

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Psychodermatoses: Diagnostic and Therapeutic Challenges

Published: Jan. 24, 2025

A complicated subgroup of psychodermatological conditions is self-induced dermatoses, which affect not only the skin but also its appendages (hair and nails). These occur when people harm themselves due to underlying mental health issues. disorders include Dermatitis Artefacta, Delusional Parasitosis, Trichotillomania, Onychotillomania Excoriation Disorder, where patients simulate or create lesions. Often, there no organic disease patient’s denial self-harm further complicates diagnosis treatment. This article explores clinical manifestations diagnostic difficulties they present essential role both dermatologists psychiatrists in managing these conditions. Recognizing psychological factors behind behaviors are vital for creating comprehensive treatment strategies that combine medical psychiatric care. Early collaboration between fundamental enhancing patient outcomes reducing risks severe consequences, such as suicide. Additionally, discusses emerging therapeutic approaches cultural perspectives ensure a global forward-thinking understanding psychodermatoses.

Language: Английский

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The Impacts of Seasonal Factors on Psoriasis

Experimental Dermatology, Journal Year: 2025, Volume and Issue: 34(3)

Published: March 1, 2025

ABSTRACT Psoriasis is a chronic inflammatory skin condition driven by immune system dysfunction, genetic predisposition and environmental factors. Patients with psoriasis experience well‐known clinical phenomenon of ‘winter severity summer relief’, in which seasonal factors play critical roles the onset progression psoriasis. These include temperature, humidity, infection, light exposure psychological stress. Seasonal changes temperature humidity can compromise barrier function exacerbate responses, thereby worsening symptoms. Notably, during winter, decreased leads to reduced vitamin D (VD) levels, reaching their lowest levels from late winter early spring. This decline VD associated increased disease activity, greater more frequent flare‐ups patients During influenza Streptococcus pneumoniae infections are prevalent, further Moreover, conditions trigger or intensify feelings depression, may adversely affect through brain–skin axis. In this comprehensive review, we thoroughly examined influence on incidence, recurrence By clarifying these complex relationships, aimed support future development personalised effective treatment management strategies for

Language: Английский

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Severity of acne vulgaris predicts maladaptive psychosocial perceptions and neuropsychiatric disorders: a case-control study

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: March 19, 2025

Abstract Acne vulgaris can negatively impact a patient’s quality of life. This study evaluated the psychological and interpersonal perceptions patients who had received acne treatment. Using data from National Institutes Health’s All Us Research Program, we analyzed survey responses 1,843 participants treated with systemic therapies for (reflecting more severe disease) matched topical alone. Outcomes included surveys assessing both mental social health prevalence neuropsychiatric conditions between groups. Compared those used only therapies, experience greater personal relational difficulties in addition to having higher rates obsessive-compulsive disorder, personality disorders, anxiety, depression. These findings were robust sensitivity analysis excluding isotretinoin-treated participants. The subset people receive therapy comprise high-risk group adverse outcomes. We aim bring awareness these issues among dermatologists other clinicians managing acne. also highlight potential need support

Language: Английский

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Causal relationship between rosacea and psychiatric disorders: a bidirectional two-sample Mendelian randomization study

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 7, 2025

Language: Английский

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Immune-Mediated and Psychiatric Comorbidities Among Patients Newly Diagnosed With Alopecia Areata

JAMA Dermatology, Journal Year: 2024, Volume and Issue: 160(9), P. 945 - 945

Published: July 31, 2024

Alopecia areata (AA) has been associated with multiple comorbidities, yet information regarding the timing of comorbidity development after AA diagnosis is limited.

Language: Английский

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Depression, Anxiety and Suicidal Ideation in Prurigo Nodularis: A Systematic Review and Meta-analysis

Acta Dermato Venereologica, Journal Year: 2024, Volume and Issue: 104, P. adv40677 - adv40677

Published: Aug. 5, 2024

Abstract is missing (Short communication)

Language: Английский

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Lifestyle interventions in dermatology

Cosmoderma, Journal Year: 2023, Volume and Issue: 3, P. 189 - 189

Published: Dec. 23, 2023

Chronic inflammatory skin disorders such as hidradenitis suppurativa and psoriasis are associated with cardiovascular disease. Lifestyle medicine is a vast evolving domain that can reduce morbidity mortality. interventions exercise, sleep, stress management, nutrition, mind-body approaches benefit several disorders. This review addresses lifestyle influence the general health outcome of patients’

Language: Английский

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