Potential Mechanisms of Casein Hexapeptide YPVEPF on Stress-Induced Anxiety and Insomnia Mice and Its Molecular Effects and Key Active Structure DOI

Jingjing Qian,

Lin Zheng, Mingtao Huang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(12), P. 6189 - 6202

Published: March 19, 2024

The hexapeptide YPVEPF with strong sleep-enhancing effects could be detected in rat brain after a single oral administration as we previously proved. In this study, the mechanism and molecular of targeted stress-induced anxiety mice were first investigated, its key active structure was further explored. results showed that significantly prolong sleep duration improve indexes, including prolonging time spent open arms center. Meanwhile, by increasing level GABA/Glu ratio, 5-HT, dopamine serum regulating anabolism multiple targets, but blocked bicuculline WAY100135. Moreover, simulation stably bind to vital GABAA 5-HT1A receptors due Tyr-Pro-Xaa-Xaa-Pro-, electrostatic van der Waals energy played dominant roles stabilizing conformation. Therefore, displayed anxiolytic GABA-Glu metabolic pathway serotoninergic system depending on distinctive self-folding structures Tyr two Pro repeats.

Language: Английский

Exploring the potential of the ketogenic diet in autism spectrum disorder: metabolic, genetic, and therapeutic insights DOI Creative Commons
Alexa Schrickel,

Jasja T. Groeneweg,

Eline Dekeyster

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 8, 2025

Abstract Current treatment approaches for Autism spectrum disorder (ASD) primarily focus on symptom management rather than addressing underlying dysfunctions. The ketogenic diet (KD), a high-fat, low-carbohydrate inducing nutritional ketosis, has shown promise in treating epilepsy and may offer therapeutic benefits ASD by modulating metabolic neuroprotective pathways. This review examined the potential impact of KD mechanisms ASD. While evidence from human studies is limited, animal research large overlap modulated dysfunctions As such, targeting multiple disrupted pathways at once, presents multifaceted approach However, more needed effectiveness modulation Additionally, precision medicine could help identify individuals who would benefit most intervention, potentially extending its use to other psychiatric conditions with similar patterns. Consequently, interventions might show induce drastic paradigm shift understanding

Language: Английский

Citations

2
Hypotheses of development and strategies for overcoming drug resistance in epilepsy. Part I: Hypotheses of development DOI Creative Commons
Alexey M. Yakimov, Elena E. Timechko,

A. I. Paramonova

et al.

Epilepsy and Paroxysmal Conditions, Journal Year: 2025, Volume and Issue: 16(4), P. 375 - 384

Published: Jan. 18, 2025

Currently, the problem of effective therapy for drug-resistant epilepsy remains vastly relevant. The severity epilepsy, remarkable negative social sequelae and sudden death in pose a heavy burden on healthcare system. Although many innovative antiepileptic drugs have been developed recent decades, surgical approach only way to treat which is coupled significant health risks does not guarantee freedom from seizures. stumbling block managing this pathology lack knowledge pathogenetic mechanisms, leaving proportion patients without quality medical care. There are different viewpoints developing drug resistance characterized by multilayered overlapping molecular disease bases. review presents analysis existing hypotheses regarding mechanisms underlying development epilepsy.

Language: Английский

Citations

2
The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy DOI Creative Commons
Anna L. M. Parsons, Eboni M. V. Bucknor, Enrico Castroflorio

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(1), P. 157 - 157

Published: Jan. 14, 2022

One of the most important characteristics brain compared to other organs is its elevated metabolic demand. Consequently, neurons consume high quantities oxygen, generating significant amounts reactive oxygen species (ROS) as a by-product. These potentially toxic molecules cause oxidative stress (OS) and are associated with many disorders nervous system, where pathological processes such aberrant protein oxidation can ultimately lead cellular dysfunction death. Epilepsy, characterized by long-term predisposition epileptic seizures, one common neurological OS. Evidence shows that increased neuronal excitability-the hallmark epilepsy-is accompanied neuroinflammation an excessive production ROS; together, these factors likely key features seizure initiation propagation. This review discusses role OS in epilepsy, connection impact on synaptic function. Considering pharmacological treatment options for epilepsy limited heterogeneity disorders, we also introduce latest advances anti-epileptic drugs (AEDs) how they interact We conclude intertwined numerous physiological molecular mechanisms although causal relationship yet be established.

Language: Английский

Citations

70
Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission DOI Open Access
Martina Montanari, Giuseppina Martella, Paola Bonsi

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3861 - 3861

Published: March 31, 2022

Disturbances in the glutamatergic system have been increasingly documented several neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered theories of ASD are based on evidence from patient samples and postmortem studies, as well studies documenting abnormalities gene expression metabolic pathways, changes gut microbiota glutamate metabolism patients with ASD. In addition, preclinical animal models demonstrated neurotransmission deficits altered synaptic proteins. At present, there no approved drugs for ASD, but ongoing clinical trials currently focusing evaluating autistic pharmaceuticals already other conditions. this review, we provide an overview literature concerning role pathophysiology a potential target novel treatments.

Language: Английский

Citations

66
The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases DOI Open Access
Yuan Zhang, Wanpeng Yu, Lei Zhang

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(24), P. 5373 - 5373

Published: Dec. 17, 2022

Polyphenols are secondary metabolites of plants and play a potential role in the prevention treatment neurodegenerative diseases (NND) such as Alzheimer’s disease (AD) Parkinson’s (PD) due to their unique physiological functions acting antioxidants, being anti-inflammatory, neuroprotective, promoting intestinal health. Since dietary polyphenols exist plant foods form glycosylation or esterification combined with polymers, they need undergo extensive metabolism through phase I II biotransformations by various enzymes, well microbiota before can be fully absorbed. improve disorders influencing structure function microbiota, inducing beneficial bacteria produce variety short-chain fatty acids (SCFAs), secretion hormones neurotransmitters, playing an important NND affecting microbe–gut–brain axis. We review ways which some change composition AD PD animal models exert slowing down progression NND, aiming provide evidence for via microbiota–gut–brain (MGB)

Language: Английский

Citations

51
The Role of the γ-Aminobutyric Acid (GABA) in Plant Salt Stress Tolerance DOI Creative Commons
Siarhei A. Dabravolski, Stanislav V. Isayenkov

Horticulturae, Journal Year: 2023, Volume and Issue: 9(2), P. 230 - 230

Published: Feb. 8, 2023

γ-Aminobutyric acid (GABA) is a non-protein amino that accumulates in many plant species response to environmental stress. A number of reverse-genetic experiments and omics analyses have revealed positive relationships between GABA levels tolerance stresses. Furthermore, the application exogenous has been demonstrated effectively reduce ROS levels, enhance membrane stability modulate phytohormones cross-talk, thus improving against multiple However, molecular mechanisms regulating homeostasis physiological functions plants remain largely unclear. In this review, we focus on recent achievements deciphering role genetic manipulations endogenous associated metabolites improve salt Finally, discuss regulation ion high-salinity conditions. These findings laid groundwork for future studies explore genetic, physiological, GABA-mediated improvements productivity under high-salt

Language: Английский

Citations

34
Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501) DOI
Yang Du, Lei Chen,

Meichen Yan

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(7), P. 3092 - 3103

Published: April 28, 2023

Language: Английский

Citations

34
Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion DOI Creative Commons
Leon D. Lotter, Simon H. Kohl, Christian Gerloff

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 146, P. 105042 - 105042

Published: Jan. 11, 2023

Humans synchronize with one another to foster successful interactions. Here, we use a multimodal data fusion approach the aim of elucidating neurobiological mechanisms by which interpersonal neural synchronization (INS) occurs. Our meta-analysis 22 functional magnetic resonance imaging and 69 near-infrared spectroscopy hyperscanning experiments (740 3721 subjects) revealed robust brain regional correlates INS in right temporoparietal junction left ventral prefrontal cortex. Integrating this meta-analytic information public databases, biobehavioral brain-functional association analyses suggested that involves sensory-integrative hubs connections mentalizing attention networks. On molecular genetic levels, found be associated GABAergic neurotransmission layer IV/V neuronal circuits, protracted developmental gene expression patterns, disorders neurodevelopment. Although limited indirect nature phenotypic-molecular analyses, our findings generate new testable hypotheses on basis INS.

Language: Английский

Citations

25
Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects DOI Creative Commons
Mehmet Arif İçer,

Buse Sarikaya,

Emine Koçyiğit

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2437 - 2437

Published: Aug. 1, 2024

The need to increase food safety and improve human health has led a worldwide in interest gamma-aminobutyric acid (GABA), produced by lactic bacteria (LABs). GABA, from glutamic reaction catalyzed glutamate decarboxylase (GAD), is four-carbon, non-protein amino that increasingly used the industry safety/quality of foods. In addition possible positive effects called postbiotic, on neuroprotection, improving sleep quality, alleviating depression relieving pain, various benefits GABA-enriched foods such as antidiabetic, antihypertension, anti-inflammatory are also being investigated. For all these reasons, it not surprising efforts identify LAB strains with high GABA productivity production LABs through genetic engineering yield accelerating. However, GABA's contributions have yet been fully discussed literature. Therefore, this current review highlights synthesis applications LABs, discusses its as, for example, drug withdrawal syndromes regulating obesity overeating. Still, other potential interactions (among others) remain unanswered questions be elucidated future. Hence, paves way toward further studies.

Language: Английский

Citations

14
A comparison between children and adolescents with autism spectrum disorders and healthy controls in biomedical factors, trace elements, and microbiota biomarkers: a meta-analysis DOI Creative Commons
Ping Lin, Qianwen Zhang, Junyu Sun

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 9, 2024

Autism spectrum disorder (ASD) is a multifaceted developmental condition that commonly appears during early childhood. The etiology of ASD remains multifactorial and not yet fully understood. identification biomarkers may provide insights into the underlying mechanisms pathophysiology disorder. present study aimed to explore causes by investigating key biomedical markers, trace elements, microbiota factors between children with autism control subjects.

Language: Английский

Citations

11