Association between oral microbiome and sleep disorders in U.S. adults: analysis of NHANES database 2009–2012 DOI Creative Commons
Guihua Hao, Yiwen Wu,

Xiaoqiao Mo

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 1, 2025

The microbiome, especially the gut contributes to regulation, etiology, and pathogenesis of sleep disorder. However, limited evidence regarding oral microbiome's role in Therefore, this study aimed investigate association between disorder microbial diversity whether microbiota is associated with all-cause mortality people included 4,729 individuals National Health Nutrition Examination Survey (NHANES) from 2009 2012 data until 2019. Sleep was assessed by structured questionnaire. microbiome characterized 16 S ribosomal RNA gene sequencing. Logistic regression models were conducted quantify α-diversity different status controlling for potential confounding variables, principal coordinate analysis along permutational multivariate variance β-diversity. using Cox proportional hazard models. showed that a lower number operational taxonomic units (OTUs) (adjusted odds ratio [aOR] = 0.996; 95% confidence interval [CI] 0.994–0.998), less Faith's phylogenetic (aOR 0.954, CI 0.934–0.975), Shannon–Weiner index 0.854, 0.772–0.944) β-diversity revealed communities two groups, as measured Bray–Curtis dissimilarity (R2 0.358%, P 0.001), unweighted UniFrac distance 0.450%, 0.001) weighted 0.709%, 0.001). Furthermore, OTUs (odds [OR] 0.999; 0.998–0.999; < 0.05), (OR 0.987; 0.975–0.998; 0.924; 0.873–0.979; inverse Simpson 0.553; 0.306–0.997; 0.05) all significant increase risk death participants Intra-population richness, inter-population dispersion, have been linked mortality. Overall, these results will help better understand etiology Further studies are required determine mechanisms underlying

Language: Английский

Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study DOI Creative Commons
Muhammed Manzoor, Jaakko Leskelä, Milla Pietiäinen

et al.

Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 22, 2024

Background Gingivitis, i.e. inflammation of the gums, is often induced by dentalplaque. However, its exact link to oral microbiota remains unclear.

Language: Английский

Citations

5
Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A Bidirectional Relationship DOI Open Access

Hardika S Vegda,

Bhavin Patel, Gaurav Girdhar

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: July 3, 2024

Nonalcoholic fatty liver disease (NAFLD) and periodontitis share common risk factors such as obesity, insulin resistance (IR), dyslipidemia, which contribute to systemic inflammation. It has been suggested that a bidirectional relationship exists between NAFLD periodontitis, indicating one condition may exacerbate the other. is characterized by excessive fat deposition in associated with low-grade chronic There are several for development of NAFLD, including gender, geriatric community, race, ethnicity, poor sleep quality deprivation, physical activity, nutritional status, dysbiosis gut microbiota, increased oxidative stress, overweight, higher body mass index (BMI), IR, type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), dyslipidemia (hypercholesterolemia), sarcopenia (decreased skeletal muscle mass). This inflammation can progression impairing immune responses exacerbating inflammatory processes periodontal tissues. Furthermore, individuals often exhibit altered lipid metabolism, affect oral microbiota composition, leading susceptibility disease. Conversely, linked through mechanisms involving stress. Chronic release pro-inflammatory cytokines bacterial toxins into bloodstream, contributing hepatic steatosis. Moreover, periodontitis-induced stress promote accumulation further aggravating NAFLD. The interplay underscores importance comprehensive management strategies targeting both conditions. Lifestyle modifications regular exercise, healthy diet, proper hygiene practices crucial preventing managing these interconnected diseases. Additionally, interdisciplinary collaboration hepatologists periodontists essential optimizing patient care improving outcomes periodontitis.

Language: Английский

Citations

5
Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review DOI Creative Commons
Georgy Leonov, Diana Salikhova, Antonina V. Starodubova

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1732 - 1732

Published: Aug. 22, 2024

Stroke represents a significant global health burden, with substantial impact on mortality, morbidity, and long-term disability. The examination of stroke biomarkers, particularly the oral microbiome, offers promising avenue for advancing our understanding factors that contribute to risk developing strategies mitigate risk. This review highlights correlations between diseases, such as periodontitis caries, onset stroke. Periodontal pathogens within microbiome have been identified contributing factor in exacerbation stroke, including obesity, dyslipidemia, atherosclerosis, hypertension, endothelial dysfunction. alteration may these conditions, emphasizing vital role prevention cardiovascular disease. integration dental medical practices enhancing efforts improving patient outcomes.

Language: Английский

Citations

5
The Gut Microbiota’s Role in Neurological, Psychiatric, and Neurodevelopmental Disorders DOI Open Access
Ioannis Alexandros Charitos, Angelo Michele Inchingolo, Laura Ferrante

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4404 - 4404

Published: Dec. 22, 2024

Aim: This article aims to explore the role of human gut microbiota (GM) in pathogenesis neurological, psychiatric, and neurodevelopmental disorders, highlighting its influence on health disease, investigating potential therapeutic strategies targeting GM modulation. Materials Methods: A comprehensive analysis microbiota’s composition interaction with body, particularly, neurological psychiatric conditions, is provided. The review discusses factors influencing composition, including birth mode, breastfeeding, diet, medications, geography. Additionally, it examines GM’s functions, such as nutrient absorption, immune regulation, pathogen defense, alongside interactions nervous system through gut–brain axis, neurotransmitters, short-chain fatty acids (SCFAs). Results: Alterations are linked various Parkinson’s multiple sclerosis, depression, schizophrenia, ADHD, autism. influences cognitive stress responses, mood regulation. Antibiotic use disrupts diversity, increasing risk metabolic obesity, allergic diseases. Emerging therapies probiotics, prebiotics, transplantation show promise modulating alleviating symptoms conditions. Conclusions. modulation represents a promising approach for personalized treatment strategies. Further research needed better understand underlying mechanisms develop targeted aimed at restoring balance improved clinical outcomes.

Language: Английский

Citations

5
Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: a systematic review of in vitro studies DOI

João Marcos Carvalho‐Silva,

Ana Beatriz Vilela Teixeira, Mariana Lima da Costa Valente

et al.

Biofouling, Journal Year: 2024, Volume and Issue: 40(2), P. 114 - 129

Published: Feb. 7, 2024

This study aimed to answer the question formulated according PICO strategy: 'Which essential oils show antimicrobial activity against biofilms formed on dental acrylic resin?' composed by population (dental resin), intervention (application of oils), comparison (denture cleansers, antifungal drugs, chlorhexidine, and oral mouthwashes), outcome (antibiofilm activity). In vitro experimental studies evaluating EOs biofilm resin were included. PRISMA guidelines followed, search was performed in PubMed, Science Direct, Embase, Lilacs databases gray literature using Google Scholar ProQuest December 2023. A manual reference lists included primary performed. Of 1467 articles identified, 37 selected for full-text reading 12 Twelve evaluated, which 11 showed Candida spp., 3 Staphylococcus aureus, 1 Pseudomonas aeruginosa. The Cymbopogon citratus, Cinnamomum zeylanicum, nardus higher action than C. Listerine, citratus nystatin, Melaleuca alternifolia fluconazole nystatin. However, chlorhexidine more effective Lippia sidoides Salvia officinalis, sodium hypochlorite L. sidoides, nystatin Zingiber officinale, Amphotericin B Eucalyptus globulus M. alternifolia. conclusion, nardus, reduce resin.

Language: Английский

Citations

4
Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis DOI Creative Commons
Nicky Linlin Liang, Bella Weijia Luo, Ivy Guofang Sun

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: 74(5), P. 987 - 998

Published: April 10, 2024

The use of sugar substitutes in food products has recently increased. Limited information regarding the role various caries prevention was found. This systematic review and meta-analysis conducted to investigate effects substitute consumption on reducing cariogenic bacteria dental plaque saliva. We systematically searched PubMed, EMBASE, Web Science (inception July 2023) for prospective controlled trials published English investigated primary outcome changes bacteria. Two independent reviewers screened papers. Quality assessed using Cochrane risk-of-bias tools. From 977 studies identified, 32 were included. Almost half (14/32, 44%) included had a high risk bias. all (31/32, 96.88%) investigations xylitol other alcohols (low-intensity sweeteners), such as sorbitol, erythritol, maltitol. Only one trial stevia, high-intensity sweetener, whereas no sweeteners, sucralose, saccharin, or aspartame, (30/32, 93.75%) showed low-intensity sweeteners led significant reduction different types results that both saliva compared treatment. helps reduce There is limited clinical evidence

Language: Английский

Citations

4
Cancer and the Microbiome of the Human Body DOI Open Access
Lourdes Herrera‐Quintana, Héctor Vázquez‐Lorente, María López-Garzón

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2790 - 2790

Published: Aug. 21, 2024

Cancer remains a public health concern worldwide, with its incidence increasing worldwide and expected to continue growing during the next decades. The microbiome has emerged as central factor in human disease, demonstrating an intricate relationship between cancer. Although some microbiomes present within local tissues have been shown restrict cancer development, mainly by interacting cells or host immune system, microorganisms are harmful risk factors for development. This review summarizes recent evidence concerning of most common types (i.e., lung, head neck, breast, gastric, colorectal, prostate, cervix cancers), providing general overview future clinical approaches perspectives.

Language: Английский

Citations

4
The forgotten link: how the oral microbiome shapes childhood growth and development DOI Creative Commons
Raymond R. Tjandrawinata, Nurlinah Amalia, Yosi Yohanes Putra Tandi

et al.

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: Feb. 7, 2025

Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive physical well-being. Emerging evidence highlights the pivotal role of oral microbiome-a dynamic microbial ecosystem-in influencing nutritional status, immune response, overall systemic health. This review explores intricate interplay between microbiome emphasizing mechanisms such dysbiosis, its impact nutrient absorption, modulation. Disruptions in can lead to malabsorption inflammation, further exacerbating impairments children. Furthermore, potential for microbiome-targeted diagnostics interventions, including probiotics prebiotics, offers novel strategies address stunting. A deeper understanding these interactions may inform innovative diagnostic tools therapeutic interventions aimed at mitigating stunting through Integrating research into prevention efforts could provide valuable insights public improve child particularly resource-limited settings. Future should focus elucidating molecular pathways linking developing personalized that optimize early life.

Language: Английский

Citations

0
Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study DOI Creative Commons
Zhengrui Li, Xufeng Huang, Qi Wang

et al.

International Dental Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exploring the role of oral bacteria in oral cancer: a narrative review DOI Creative Commons

Hassan Mivehchi,

Aisan Eskandari-Yaghbastlo,

Parnian Pour Bahrami

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

A growing body of research indicates that a wide range cancer types may correlate with human microbiome components. On the other hand, little is known about potential contribution oral microbiota to cancer. However, some components can stimulate different tumorigenic processes associated development In this line, two prevalent infections, Porphyromonas gingivalis, and Fusobacterium nucleatum increase tumor growth. The impact course illness through direct interactions major modifications toxicity responsiveness kinds therapy. Recent has demonstrated relationship between specific phylogenetic groupings results immunotherapy treatment for particular types. Conversely, there been recent upsurge in interest possibility using microbes treat At moment, species, such as Salmonella typhimurium Clostridium spp., are being explored possible vectors. Thus, understanding these microbial highlights importance maintaining healthy preventing cancers. From perspective, review will discuss role on cancers their application treatment/improvement.

Language: Английский

Citations

0