Multidimensional relationships between sensory perception and cognitive aging DOI Creative Commons
Lakshmi Kannan, E. Sebastian Lelo de Larrea-Mancera, Marcello Maniglia

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 20, 2024

A growing literature suggests that declines in sensory/perceptual systems predate cognitive aging, and furthermore, they are highly predictive for developing Alzheimer's disease related dementias (ADRD). While vision, hearing, olfaction, vestibular function have each been shown to be ADRD, their causal relations declines, how interact with other remains clarified. Currently, there is substantial debate whether fail early progression contributions load and/or social isolation or simply coincident due aging. At the same time, any of these senses requires compensation, can strain neural processes impact activities daily living, including engagement, quality life, risk falls. In this perspective piece, we review illustrates different relationships between systems, aging ADRD. We suggest broadly administered precise assessment functions could facilitate detection ADRD pave way intervention strategies help reduce multifaceted improve everyday functioning as people age.

Language: Английский

Talking While Walking After Concussion: Acute Effects of Concussion on Speech Pauses and Gait Speed DOI

Shu Yang,

Paula Johnson, C. Hansen

et al.

Neurorehabilitation and neural repair, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Background Deficits in dual-tasks (DT) are frequently observed post-concussion (ie, mild Traumatic Brain Injury). However, traditional DT may not be relevant to daily life. Walking while talking elicits costs healthy adults and is part of Objective We investigated the effect concussion on walking with extemporaneous speech explored relationships between acute symptoms. Methods Participants recent (<14 days post-injury) controls completed 3 tasks: single-task gait without speaking (ST G ), S (DT). Silent pauses audio reflected cognitive performance, was quantified using inertial sensors. used linear mixed models compare groups conditions associations self-reported Results Both (n = 19) control 18) exhibited longer ( P < .001), slower speeds cadence .001) during compared ST conditions. There were no group differences or interactions for > .424). The slowed down more than (group × task .032). Vestibular symptoms strongly associated pause duration (ρ .72), speed −.75), −.78). Conclusions Extemporaneous well-practiced but challenging complete post-concussion. Strong outcomes vestibular-related suggest deficits vary symptomology. deleterious tasks

Language: Английский

Citations

0
Posterior parietal cortex activity during visually cued gait: a preliminary study DOI Creative Commons

Paul M. McDonnell,

Adam B. Grimmitt, Jonaz Moreno Jaramillo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Safe gait requires visually cued (VC) step adjustments for negotiating targets and obstacles. Effective rely on good visuospatial processing. The posterior parietal cortex (PPC) is implicated in processing, yet empirical evidence limited the PPC’s role during humans. Increased cortical control of associated with higher variability, a marker performance fall risk among older adults. However, underpinnings variability complex environments are not well established. primary aim this preliminary study was to assess PPC activity VC perturbations (VCP). A secondary determine how relates VCP gait. Twenty-one healthy young adults completed three treadmill conditions at preferred speed: non-cued (NC) gait, where stepping were presented regular pattern, target positions pseudorandomly shifted. Functional near-infrared spectroscopy quantified relative changes deoxygenated oxygenated hemoglobin (ΔHbO 2 ) concentrations PPC. Inertial measurement units variability. Moderate effects observed more positive ΔHbO from NC both likely reflecting increased processing demands. Stride time positively correlated suggesting potential modulating temporal components Extending these findings will help elucidate adaptability aging.

Language: Английский

Citations

0
Cerebral Haemodynamic Assessment Following Sport-related Concussion (Mild Traumatic Brain Injury) in Youth and Amateur Rugby Union Players DOI Creative Commons
Benjamin Jones, Mohammadreza Jamalifard, Sally Waterworth

et al.

Sports Medicine - Open, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 2, 2025

Abstract Background Using functional near-infrared spectroscopy (fNIRS) as an objective diagnostic tool, we aimed to (1) compare fNIRS measurements in adult and youth male rugby players against controls over a playing season, 2) document the changes that occur concussed during England Rugby Football Union Graduated Return-To-Play programme (GRTP). Sixty-seven participants (rugby = 41 (26 adults: 27.5 ± 4.4 years; 15 youth: 16.5 0.6 control 26 (11 adult: 30.5 5.2 16.9 0.4 years) completed assessments at pre, mid end-season. Eight (five youth, three adult) sustained concussions, Graded Symptom Checklist from Sport Concussion Assessment Tool version 5 (SCAT5) assessment throughout GRTP period. Mixed linear models were utilised assess effect of group time on measures oxyhaemoglobin (∆O 2 Hb) deoxyhaemoglobin (∆HHb) performance tasks. Typical Error (TE) i.e., normal biological fluctuation measurement error, was calculated identify ‘cut-off’ thresholds for identifying effects concussion. Results There significant differences indices groups ( p < 0.05) but no between > 0.05). Seven out eight (87.5%) showed greater than TE period both ∆O Hb ∆HHb tasks these players’ profiles had not returned within ‘normal’ levels All symptom severity number Conclusion Current protocols alone are problematic there is need more individualised approach concussion management, utilising biomarker tools such fNIRS.

Language: Английский

Citations

0
Talking while Walking After Concussion: Acute effects of concussion on speech pauses and gait speed DOI Open Access

Shu Yang,

Paula Johnson, C. Hansen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 7, 2024

Deficits in dual-tasks (DT) are frequently observed post-concussion (i.e., mild Traumatic Brain Injury). However, traditional DT may not be relevant to daily life. Walking while talking elicits costs healthy adults and is part of

Language: Английский

Citations

1
Altered neural recruitment despite dual task performance recovery in athletes with repeat concussion DOI Creative Commons
Andrew C. Hagen, Brian Tracy, Jaclyn A. Stephens

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Sports-related concussions (SRCs) pose significant challenges to college-aged athletes, eliciting both immediate symptoms and subacute cognitive motor function impairment. While most impairments resolve within weeks, athletes with repeat SRCs may experience heightened risk for prolonged recovery trajectories, future musculoskeletal injuries, long-term neurocognitive deficits. This includes impaired dual task performance altered neurophysiology that could persist across the lifespan elicit pathophysiology neurodegeneration. Thus, it is imperative improve our understanding of after SRC. study aimed investigate impact on associated neural recruitment using functional near-infrared spectroscopy (fNIRS). A total 37 (ages 18-24) participated in this cross-sectional observational study. Among these 20 had a history two or more SRCs, while 17 never sustained SRC served as controls. Participants completed Neuroimaging-Compatible Dual Task Screen (NC-DTS) fNIRS measured frontoparietal attention network primary sensory cortices. Behavioral analysis revealed exhibited comparable single control athletes. Additionally, effects (DTE), which capture declines tasks versus tasks, did not significantly differ between groups. Notably, cohort longer time since their last (mean = 1.75 years) than majority previous studies. Neuroimaging results indicated patterns multiple during tasks. Specifically, demonstrated increased prefrontal cortex (PFC) activation compared controls ( P < 0.001, d 0.47). Conversely, same reduced PFC 0.29) (M1) 0.038, 0.16) activation. These findings emphasize complex relationship history, performance, changes neurophysiology. demonstrate behavioral persistent alterations suggest ongoing neurophysiological changes, possibly indicating compensatory strategies inefficient resource allocation, even beyond symptom resolution medical clearance. Understanding support following can inform return-to-play decisions, injury risk, function.

Language: Английский

Citations

1
Altered neural recruitment during single and dual tasks in athletes with repeat concussion DOI Creative Commons
Andrew C. Hagen, Brian Tracy, Jaclyn A. Stephens

et al.

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 11, 2024

Sports-related concussions (SRCs) pose significant challenges to college-aged athletes, eliciting both immediate symptoms and subacute cognitive motor function impairment. While most impairments resolve within weeks, athletes with repeat SRCs may experience heightened risk for prolonged recovery trajectories, future musculoskeletal injuries, long-term neurocognitive deficits. This study aimed investigate the impact of on dual task performance associated neural recruitment using functional near-infrared spectroscopy (fNIRS). A total 37 (ages 18–24) participated in this cross-sectional observational study, 20 a history two or more SRCs, 17 controls that had never sustained an SRC. Participants completed Neuroimaging-Compatible Dual Task Screen (NC-DTS) while frontoparietal attention network primary sensory cortices was measured fNIRS. Athletes exhibited comparable single control athletes. Neuroimaging results indicated altered patterns during tasks. Specifically, demonstrated increased prefrontal cortex (PFC) activation tasks compared ( p &lt; 0.001, d = 0.47). Conversely, tasks, these same reduced PFC 0.29) their activation. These findings emphasize demonstrate typical performance, persistent alterations suggest ongoing neurophysiological changes, possibly indicating compensatory strategies inefficient resource allocation, even beyond symptom resolution medical clearance.

Language: Английский

Citations

1
Theta oscillations in observers’ temporal cortex index postural instability of point-light displays DOI Creative Commons
Banty Tia, Mitsuaki Takemi, Thierry Pozzo

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 561, P. 107 - 118

Published: Oct. 19, 2024

Language: Английский

Citations

0
Multidimensional relationships between sensory perception and cognitive aging DOI Creative Commons
Lakshmi Kannan, E. Sebastian Lelo de Larrea-Mancera, Marcello Maniglia

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 20, 2024

A growing literature suggests that declines in sensory/perceptual systems predate cognitive aging, and furthermore, they are highly predictive for developing Alzheimer's disease related dementias (ADRD). While vision, hearing, olfaction, vestibular function have each been shown to be ADRD, their causal relations declines, how interact with other remains clarified. Currently, there is substantial debate whether fail early progression contributions load and/or social isolation or simply coincident due aging. At the same time, any of these senses requires compensation, can strain neural processes impact activities daily living, including engagement, quality life, risk falls. In this perspective piece, we review illustrates different relationships between systems, aging ADRD. We suggest broadly administered precise assessment functions could facilitate detection ADRD pave way intervention strategies help reduce multifaceted improve everyday functioning as people age.

Language: Английский

Citations

0