Therapeutic Effects of 35 kDa Hyaluronan Injection at Trigger Points in the Treatment of Myofascial Pain Syndrome

International Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 16(01), P. 1 - 15

Published: Jan. 1, 2025

Language: Английский

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Application of 35 kDa Hyaluronic Acid Fragment in Managing Persistent Localized Pain in Rheumatoid Arthritis : A Case Report

Clinical Case Reports, Journal Year: 2025, Volume and Issue: 13(4)

Published: March 28, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic joint inflammation, leading to damage and pain. This case report presents 58-year-old Chinese female who developed widespread pain after contracting mild COVID-19 was subsequently diagnosed with RA. Her symptoms included swelling, pain, abnormal serological markers. Initial treatment methylprednisolone tofacitinib discontinued due side effects, she switched combined approach of herbal Western medicine. After year treatment, her swelling largely resolved, leaving persistent localized in specific joints. To address this received 35 kDa hyaluronan fragment (HA35) injections, resulting significant improvement, including complete relief elbow knee restored mobility. Continuous HA35 followed oral powder, also completely relieved foot highlights the effectiveness managing RA particularly for residual conventional treatments, suggests its potential as therapeutic option.

Language: Английский

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Size-dependent aggregation of erythrocytes by low molecular weight hyaluronic acids of different sizes: bioactivity and quality control potential

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Hyaluronic acid (HA) is a crucial biological molecule whose diverse functions are strongly influenced by its molecular weight. In particular, low weight HA (LMW-HA) fragments-such as HA60 (average 60 kDa), HA35 35 and HA24 24 kDa)-exhibit enhanced tissue permeability unique interactions with cell surfaces compared to high (HMW-HA). This study investigates the size-dependent aggregation effects of LMW-HA on erythrocytes examines implications for bioactivity, quality control, therapeutic applications. We investigated fragments erythrocyte across sizes using sedimentation rate (ESR) assays, CD44 receptor blocking assessment via gel electrophoresis GPC-MALLS. samples were applied at varying concentrations measure their binding affinity erythrocytes, while antibodies used assess involvement. Species-specificity was examined comparing from different animals. induced in manner, exhibiting strongest affinity, followed HA24. Aggregation partially reversible could be inhibited antibodies, indicating receptor-mediated interaction. Minimum effective inversely related weight, lower requiring higher concentrations. Species-specific also observed, highlighting variations erythrocyte-HA The suggests that facilitates through CD44-mediated binding, offering insights into HA's role physiology blood rheology. findings support potential applications pain inflammation management, given interaction erythrocytes. Additionally, provides valuable parameter enabling consistency products. These results underscore importance determining physiological pharmacological activity, paving way further clinical research confirm species-specific optimize safe uses LMW-HA.

Language: Английский

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Analgesic Effect of 35 kDa Hyaluronan Fragment on Vaginal Oocyte Retrieval Operation-Associated Pain: A Case Report

Case Reports in Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 503 - 511

Published: Jan. 1, 2024

Language: Английский

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