Changes of intestinal microbiome and its relationship with painful diabetic neuropathy in rats DOI Creative Commons
Shuaiying Jia,

Haiqi Mi,

Su Yao

et al.

BMC Microbiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 8, 2025

To analyze the gut bacterial microbiome in rats with painful diabetic neuropathy (PDN) compared to normal rats. Type 2 diabetes was induced via a high-fat and high-sugar diet combined low dose of streptozotocin. Glucose metabolism insulin sensitivity were evaluated using intraperitoneal glucose tolerance tests tests. The progression peripheral assessed mechanical withdrawal threshold thermal latency. Histopathological analysis rat colon tissues performed hematoxylin-eosin staining observe morphological changes. expression levels pro-inflammatory cytokines TNF-α IL-1β spinal cord measured enzyme-linked immunosorbent assay (ELISA). Fecal samples then collected for metagenomic sequencing analysis. Behavioral revealed reduced latency PDN Histological showed significant colonic mucosal damage inflammatory cell infiltration, suggesting impaired intestinal barrier function. Elevated further highlight inflammation's role PDN. Sequencing differences microbiota composition between control rats, altered Bacillota/Bacteroidota ratios increased Lactobacillus abundance. Functional annotation analysis, based on KEGG, EggNOG, CAZy databases, indicated enrichment metabolic pathways related carbohydrate amino acid metabolism, energy structure biogenesis Cluster identified higher functional clustering Metabolism Genetic Information Processing This study demonstrates that leads composition, disrupted pathways, inflammation, contributing pathological neuropathy. provides new insights into interplay neuropathy, offering potential avenues therapeutic interventions targeting metabolism.

Language: Английский

Pain-resolving immune mechanisms in neuropathic pain DOI
Nathan T. Fiore, Sophie R. Debs, Jessica P. Hayes

et al.

Nature Reviews Neurology, Journal Year: 2023, Volume and Issue: unknown

Published: March 1, 2023

Language: Английский

Citations

107
Gut Microbiome in Anesthesiology and Pain Medicine DOI Open Access
Amir Minerbi, Shiqian Shen

Anesthesiology, Journal Year: 2022, Volume and Issue: 137(1), P. 93 - 108

Published: April 29, 2022

The gut microbiome plays critical roles in human health and disease. Recent studies suggest it may also be associated with chronic pain postoperative outcomes. In animal models, the composition of changes after general anesthesia affects host response to medications, including anesthetics opioids. humans, is development neurocognitive disorders. Additionally, has been conditions visceral pain, nociplastic complex regional syndrome, headaches, partly through altered concentration circulating bacterial-derived metabolites. Furthermore, demonstrate role neuropathic via immunomodulatory mechanisms. This article reviews basic concepts its interactions provide a comprehensive overview evidence linking anesthesiology, care, medicine.

Language: Английский

Citations

42
Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain DOI

Wenyao Wu,

Xianwei Zhang, Shuo Wang

et al.

Neuropharmacology, Journal Year: 2022, Volume and Issue: 217, P. 109206 - 109206

Published: Aug. 1, 2022

Language: Английский

Citations

41
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis DOI Creative Commons

Pei Luo,

Kristen Lednovich, Kai Xu

et al.

Translational research, Journal Year: 2022, Volume and Issue: 248, P. 128 - 150

Published: June 7, 2022

Language: Английский

Citations

39
Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies DOI
Liping Liu, Qin Wu, Yuping Chen

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 115, P. 109685 - 109685

Published: Jan. 25, 2023

Language: Английский

Citations

36
Pectin mediates the mechanism of host blood glucose regulation through intestinal flora DOI
Qing Guo, Xiaoyan Hou,

Qiang Cui

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(19), P. 6714 - 6736

Published: Feb. 9, 2023

AbstractPectin is a complex polysaccharide found in plant cell walls and interlayers. As food component, pectin benefit for regulating intestinal flora. Metabolites of flora, including short-chain fatty acids (SCFAs), bile (BAs) lipopolysaccharides (LPS), are involved blood glucose regulation. SCFAs promote insulin synthesis through the intestine-GPCRs-derived pathway hepatic adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) to glycogen synthesis. On one hand, BAs stimulate L cells pancreatic α secrete Glucagon-like peptide-1 (GLP-1) peptide YY (PYY) receptors G protein-coupled receptor (TGR5) farnesoid X (FXR). other AMPK pathway. LPS inhibits release inflammatory cytokines Toll-like (TLRs)-myeloid differentiation factor 88 (MYD88) mitogen-activated (MAPK) pathway, thereby alleviating resistance (IR). In brief, both GLP-1 secretion different pathways, employing strategies increasing consumption decreasing production maintain normal levels. Notably, can also directly inhibit -TLRs-MYD88 These data provide valuable information further elucidating relationship between pectin-intestinal flora-glucose metabolism.Keywords: acidsblood regulationintestinal florapectinshort-chain Disclosure statementThe authors declare no conflicts interest.Additional informationFundingThis work was supported by Key Research & Development Project [2021YFN0016] Science Technology Department Sichuan Province, People's Republic China.

Language: Английский

Citations

26
Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic DOI Creative Commons

Wen-Xiang Duan,

Fen Wang, Junyi Liu

et al.

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 40(4), P. 500 - 516

Published: Sept. 27, 2023

Parkinson's disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, massive loss midbrain dopamine neurons. Increasing evidence suggests that gut microbiota microbial metabolites are involved development PD. Among these, short-chain fatty acids (SCFAs), most abundant metabolites, have been proven to play key role brain-gut communication. In this review, we analyze SCFAs pathology PD from multiple dimensions summarize alterations patients as well their correlation with motor non-motor symptoms. Future research should focus on further elucidating neuroinflammation, developing novel strategies employing derivatives treat

Language: Английский

Citations

24
Chronic Pain–Related Cognitive Deficits: Preclinical Insights into Molecular, Cellular, and Circuit Mechanisms DOI
Siyi Han, Jie Wang, Wen Zhang

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(10), P. 8123 - 8143

Published: March 12, 2024

Language: Английский

Citations

9
Probiotics alleviate painful diabetic neuropathy by modulating the microbiota–gut–nerve axis in rats DOI Creative Commons
Ye Jiang, Jing Yang, Min Wei

et al.

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 2, 2025

Language: Английский

Citations

1
Mechanisms of comorbidity between Alzheimer's disease and pain DOI Creative Commons
Kaifang Yao, Shenjun Wang, Zhifang Xu

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(2)

Published: Feb. 1, 2025

ABSTRACT Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive speech impairments, AD patients, especially those in moderate severe stages, are often overlooked management. The challenges obtaining pain‐related information from this population exacerbate the issue. Although recent clinical research has increasingly recognized comorbidity of pain, pathological alterations interactive mechanisms underlying relationship remain inadequately explored. This review provides comprehensive analysis features with without comorbidity. It examines processes, including neuroinflammation, peripheral‐central immune interactions, neurotransmitter dynamics. Furthermore, it highlights current assessment management strategies patients. By offering theoretical framework, aims support development effective approaches serve as reference for interventions targeting AD‐associated pain. Highlights CP encompasses multiple interrelated biological pathways, such neurodegeneration inflammatory responses. damage neurons synapses patients influences brain regions responsible processing thereby reducing response. Neuroinflammation plays vital role both CP. Enhanced responses an impact on CNS promote sensitization. Common exist CP, influencing cognition, emotion, perception.

Language: Английский

Citations

1