International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3242 - 3242

Published: March 31, 2025

Killer Ig-like Receptors (KIRs) regulate immune responses, maintaining the balance between activation and inhibition of system. KIRs are expressed on natural killer cells some CD8 T interact with HLA class I molecules, influencing various physiological pathological processes. KIRs' polymorphism creates a variability in responses among individuals. involved autoimmune disorders, cancer, infections, neurological diseases, other diseases. Specific combinations linked to several diseases' susceptibility, progression, outcomes. In particular, inhibitory activating can determine how system responds pathogens tumors. An imbalance lead an excessive response, contributing or inadequate allowing evasion by cancer cells. The increasing number studies highlights their essential role as diagnostic prognostic biomarkers potential therapeutic targets. This review provides comprehensive overview all clinical conditions listed alphabetically, where they analyzed.

Language: Английский