Prolactin Role in COVID-19 and Its Association with the Underlying Inflammatory Response DOI Open Access

Eleni Polyzou,

Georgios Schinas, Panagiotis Bountouris

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11905 - 11905

Published: Nov. 6, 2024

The COVID-19 pandemic has prompted interest in identifying reliable biomarkers to predict disease severity and guide clinical decisions. Prolactin (PRL), a hormone traditionally associated with lactation, gained attention for its role immune modulation. This study aimed assess PRL as biomarker COVID-19. A prospective cohort of 142 patients moderate severe COVID-19, defined WHO-CPS 5 or 6, was recruited from the University General Hospital Patras. Baseline levels were measured using an electrochemiluminescence immunoassay, serum cytokines, including IL-1β, IL-6, IL-8, IL-10, IL-12p70, TNF-α, quantified through flow cytometry. Clinical outcomes, mortality need invasive mechanical ventilation (IMV), recorded. Results indicated that significantly higher female (12.95 ng/mL vs. 9.40 ng/mL,

Language: Английский

Association between serum levels of GDF-15, suPAR, PIVKA-II, sdLDL and clinical outcomes in hospitalized COVID-19 patients DOI Creative Commons
Alessio Molfino, Emanuela Anastasi,

Eleonora Assanto

et al.

Internal and Emergency Medicine, Journal Year: 2024, Volume and Issue: 19(6), P. 1557 - 1566

Published: May 3, 2024

To quantify the circulating levels of novel serum biomarkers including GDF-15, PIVKA-II, sdLDL, suPAR, and CRP in hospitalized COVID-19 patients compared with healthy subjects, to evaluate their association(s) outcomes COVID-19. We considered confirmed COVID-19, an Internal Medicine ward. The clinical characteristics were collected, number type comorbidities. Serum as well measured. As outcomes, we Intensive Care Unit (ICU) transfer or death, length stay (days) in-hospital complications. Data statistically analyzed, appropriate, a p value < 0.05 was significant. Ninety-three 20 controls enrolled. vs. showed higher median GDF-15 (p 0.0001), PIVKA-II 0.0001) sdLDL = 0.0002), whereas no difference observed for suPAR. In patients, most frequent comorbidities arterial hypertension (62.4%) cardiovascular disease (30.1%). positively correlated age (r 0.433, this correlation suPAR 0.308, 0.003) (Rho 0.40 but not sdLDL. Higher associated 0.021). 22 (15; 30) days. During hospitalization, 15 (16%) ICU transferred, 6 (6.45%) died. (rho 0.27 0.010), death 0.003), 0.038) 0.001). Moreover, infectious complications 0.008 0.017, respectively). cohort inflammatory biomarkers, PIVKA II some patient's characteristics, complications, poor outcomes.

Language: Английский

Citations

5
The predictive value of endocan as a novel biomarker: an umbrella study on meta-analyses DOI Creative Commons
Sandeep Samethadka Nayak,

Daniyal Ameen,

Sara Nobakht

et al.

Systematic Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: May 1, 2025

In recent years, endocan has emerged as a potential biomarker in various medical conditions. This multifaceted molecule, involved key processes such inflammation and endothelial dysfunction, shown promise predicting disease progression therapeutic response across spectrum of pathologies. However, the heterogeneity studies complexity endocan's role different diseases necessitate comprehensive review. umbrella review aimed to systematically synthesize evaluate evidence from multiple meta-analyses, offering view effectiveness predictive diseases. An extensive search was carried out on March 12, 2024, using following four databases: PubMed, Scopus, Web Science, Cochrane Library. The goal identify meta-analyses that assess efficacy. pooled effect size its 95% confidence interval were taken each discovered meta-analysis. Furthermore, power analyses performed robustness dependability results. additional GRADE assessment gauge epidemiological reliability findings. final analysis, 12 included current results showed there is significant correlation between higher level COVID-19 (SMD: 1.40, CI 0.21-2.58, P = 0.02), followed by chronic kidney 1.34, 0.20 2.48, < 0.01), obstructive sleep apnea 1.30, 1.06-1.54, diabetes mellitus 1.00, 0.81 1.19, coronary artery 0.99, 0.58-1.39, hypertension 0.91, 0.44-1.38, preeclampsia 0.37, 0.13-0.62, 0.01). Endocan highly promising with considerable Its relevance spans critical areas COVID-19, disease, apnea, mellitus, preeclampsia. broad applicability highlights value improving diagnostic accuracy enhancing our understanding these Clinically, incorporating testing could aid early detection, monitoring progression, refining patient management, particularly for high-risk populations. research needed fully specificity, sensitivity, overall clinical utility, paving way integration into routine healthcare practices enabling more precise, individualized treatment strategies.

Language: Английский

Citations

0
Soluble Urokinase-Type Plasminogen Activator Receptor and Inflammatory Biomarker Response with Prognostic Significance after Acute Neuronal Injury – a Prospective Cohort Study DOI Creative Commons

Antti Sajanti,

Santtu Hellström,

Carolyn M. Bennett

et al.

Inflammation, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Aneurysmal subarachnoid hemorrhage (aSAH), ischemic stroke (IS), and traumatic brain injury (TBI) are severe conditions impacting individuals society. Identifying reliable prognostic biomarkers for predicting survival or recovery remains a challenge. Soluble urokinase type plasminogen activator receptor (suPAR) has gained attention as potential biomarker in acute sepsis. This study evaluates suPAR related neuroinflammatory serum prognosis. prospective included 31 aSAH, 30 IS, 13 TBI, three healthy controls (n = 77). Serum samples were collected on average 5.9 days post-injury, analyzing suPAR, IL-1β, cyclophilin A, TNFα levels using ELISA. Outcomes assessed 90 post-injury with the modified Rankin Scale (mRS), categorized favorable (mRS 0-2) unfavorable 3-6). Statistical analyses 2-tailed t-tests, Pearson's correlations, machine learning linear discriminant analysis (LDA) combinations. Elevated found patients compared to (p 0.017). Increased correlated outcomes 0.0018) showed value (AUC 0.66, p 0.03). IL-1β higher group 0.0015). LDA combinatory resulted fair accuracy canonical equation 0.775[suPAR] + 0.667[IL1-β] 0.77, OR 0.296, sensitivity 93.1%, specificity 53.1%, 0.0007). No correlation was between CRP infection status. associated poorer outcomes, highlighting suPAR's across different types. Combining improved accuracy, supporting multimodal approach outcomes.

Language: Английский

Citations

1
Prolactin Role in COVID-19 and Its Association with the Underlying Inflammatory Response DOI Open Access

Eleni Polyzou,

Georgios Schinas, Panagiotis Bountouris

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11905 - 11905

Published: Nov. 6, 2024

The COVID-19 pandemic has prompted interest in identifying reliable biomarkers to predict disease severity and guide clinical decisions. Prolactin (PRL), a hormone traditionally associated with lactation, gained attention for its role immune modulation. This study aimed assess PRL as biomarker COVID-19. A prospective cohort of 142 patients moderate severe COVID-19, defined WHO-CPS 5 or 6, was recruited from the University General Hospital Patras. Baseline levels were measured using an electrochemiluminescence immunoassay, serum cytokines, including IL-1β, IL-6, IL-8, IL-10, IL-12p70, TNF-α, quantified through flow cytometry. Clinical outcomes, mortality need invasive mechanical ventilation (IMV), recorded. Results indicated that significantly higher female (12.95 ng/mL vs. 9.40 ng/mL,

Language: Английский

Citations

0