Identification of potential crucial genes shared in psoriasis and ulcerative colitis by machine learning and integrated bioinformatics

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(2)

Published: Feb. 1, 2024

Abstract Background Mounting evidence suggest that there are an association between psoriasis and ulcerative colitis (UC), although the common pathogeneses not fully understood. Our study aimed to find potential crucial genes in UC through machine learning integrated bioinformatics. Methods The overlapping differentially expressed (DEGs) of datasets GSE13355 GSE87466 were identified. Then functional enrichment analysis was performed. LASSO, SVM‐RFE key module WGCNA considered as genes. receiver operator characteristic (ROC) curve used estimate their diagnostic confidence. CIBERSORT conducted evaluate immune cell infiltration. Finally, GSE30999 GSE107499 retrieved validate. Results 112 DEGs identified revealed they closely related inflammatory response. Eight genes, including S100A9, PI3, KYNU, WNT5A, SERPINB3, CHI3L2, ARNTL2, SLAMF7, ultimately ROC curves showed all had high confidence test validation datasets. indicated a correlation infiltrating cells Conclusion In our study, we focused on comprehensive understanding UC. identification eight may contribute only mechanism, but also identifying occult patients, even serving therapeutic targets future.

Language: Английский

---

Precision medicine in inflammatory bowel disease

Precision Clinical Medicine, Journal Year: 2023, Volume and Issue: 6(4)

Published: Oct. 25, 2023

Abstract Inflammatory bowel disease (IBD) is an incurable characterized by remission-relapse cycles throughout its course. Both Crohn's (CD) and ulcerative colitis (UC), the two main forms of IBD, exhibit tendency to develop complications substantial heterogeneity in terms frequency severity relapse, thus posing great challenges clinical management for IBD. Current treatment strategies are effective different ways induction maintenance therapies Recent advances studies genetics, pharmacogenetics, proteomics microbiome provide a strong driving force identifying molecular markers prognosis response, which should help clinicians manage IBD patients more effectively, then, improve outcomes reduce costs patients. In this review, we summarize discuss precision medicine focusing on predictive course monitoring indices during therapeutic drug monitoring.

Language: Английский

---

Anti-CD20 monoclonal antibody (mAb) therapy and colitis: A case series and review

Multiple Sclerosis and Related Disorders, Journal Year: 2023, Volume and Issue: 75, P. 104763 - 104763

Published: May 15, 2023

Language: Английский

---

Thyroid disorders and inflammatory bowel disease: an association present in adults but also in children and adolescents

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

Inflammatory bowel diseases (IBD) represent chronic inflammatory multisystemic disorders that primarily involve the gastrointestinal tract. Patients with ulcerative colitis (UC) and Crohn’s disease (CD) exhibit a higher prevalence of thyroid compared to general population. The aim this review is summarize literature on concomitant IBD disorders, specifically autoimmune such as Graves’ (GD) Hashimoto’s thyroiditis (HT), well cancer, focus children adolescents. We provide an overview age-related differences between adults in association. Literature shows relatively few studies have been conducted subject pediatric populations. etiopathogenetic similarities are undeniable. Nevertheless, current data does not indicate unanimous association GD HT (both CD UC). Although evidence suggests potential particularly papillary precise nature relationship varies across influenced by multiple factors. limited information regarding highlights significant knowledge gap. Since plays critical role population’s development, it essential promptly recognize treat diseases. A function monitoring future research exploring genetic immunologic connections enhance our understanding interrelation disorders.

Language: Английский

---

Ocrelizumab-induced colitis—critical review and case series from a Romanian cohort of MS patients

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Background Widespread use of ocrelizumab, an anti-CD20 monoclonal antibody, for treating patients with multiple sclerosis (MS), has led to increase in reported adverse events following real-world observation. Among these, drug-induced colitis is a rare, but severe side effect, prompting recent FDA statement regarding this safety concern. Objectives: We analyzed cohort ocrelizumab treated our MS center evaluate the incidence colitis. Methods present critical review available literature on diagnosis and management induced display case series 3 suspected cohort. Results Two met full criteria ocrelizumab-induced colitis, while third partially criteria. Following symptomatic treatment discontinuation showed favorable outcomes. Conclusion Ocrelizumab-induced event. Its may be higher than expected, reaching 1,95% patients. Further reporting such cases essential broaden understanding effect.

Language: Английский

---

Exploring the genetic components and multi-omics sources of inflammatory bowel disease from the perspective of autoimmune disorders

Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

---

Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Introduction Psoriasis is a T-cell mediated autoimmune skin disease. HLA-C*06:02 the main psoriasis-specific risk gene. Using Vα3S1/Vβ13S1 receptor (TCR) from lesional psoriatic CD8 + clone we had discovered that, as an underlying pathomechanism, mediates response against melanocytes in psoriasis, and identified epitope ADAMTS-like protein 5 (ADAMTSL5) melanocyte autoantigen. The conditions activating genetically predisposed individuals throughout life remain incompletely understood. Here, aimed to identify environmental antigens that might trigger autoimmunity psoriasis because of TCR polyspecificity. Methods We screened databases with peptide recognition motif for proteins containing peptides this TCR. investigated immunogenicity these patients healthy controls by lymphocyte stimulation experiments peptide-loaded tetramers. Results wheat, Saccharomyces cerevisiae , microbiota, tobacco, pathogens activated both T cells patients. fluorescent tetramers loaded ADAMTSL5 or wheat peptides, find same may recognize autoantigen antigens. A wheat-free diet could alleviate several Discussion Our results show due polyspecificity, corresponding previously suspected converge reactivity pathogenic thus be able stimulate melanocytes. Avoiding factors contribute management psoriasis.

Language: Английский

---

Hepatobiliary and pancreatic manifestations in inflammatory bowel disease: an umbrella review of meta-analyses

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Background: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s (CD), can affect the hepatobiliary system pancreas, substantially impacting life quality of patients. Objectives: To evaluate evidence comprehensively assess validity associations IBD with pancreatic diseases. Design: We performed an umbrella review existing meta-analyses in accordance Preferred Reporting Items for Systematic Review Meta-Analyses (PRISMA) recommendations. Data sources methods: systematically searched PubMed, Embase, Web Science from inception to April 2024, identify appraise examining risk manifestations. Methodologic was assessed A Measurement Tool Assess Reviews (AMSTAR 2) strength graded according prespecified criteria. Results: total 14 observational studies were included. The strongest-validity suggested significant between gallstones (odds ratio (OR) = 1.72; 95% confidence interval (CI) 1.40–2.12) acute pancreatitis (OR 3.11; CI 2.93–3.30). Highly suggestive indicated a significantly increased cancer UC (incidence rate (IRR) 2.05; 1.52–2.76) CD (IRR 2.31; 1.25–4.28). In addition, highly that associated portal venous thrombosis. Suggestive showed higher prevalence primary sclerosing cholangitis, non-alcoholic fatty liver disease, autoimmune hepatitis, patients than general population. Conclusion: multiple disorders varying levels magnitude risk. Further high-quality are needed who more at would benefit most screening prevention programs. Trial registration (PROSPERO): CRD42023451461.

Language: Английский

---

Exploration of the Mechanism of Lithospermum erythrorhizon Oil in Treating Atopic Dermatitis Based on Network Pharmacology and Experimental Validation of the PI3K-Akt Pathway Regulation

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e41707 - e41707

Published: Jan. 1, 2025

This study aimed to explore the molecular mechanisms of Lithospermum erythrorhizon oil in treating atopic dermatitis (AD), with a particular focus on its regulatory effect PI3K-Akt signaling pathway. Utilizing network pharmacology approach integrated experimental validation, we identified active components and potential targets via TCMSP, ChemSrc, PubChem, PharmMapper. Common were selected by intersecting these AD-related from GeneCards. A protein-protein interaction (PPI) was built using STRING, functional analysis Gene Ontology (GO) pathway enrichment Kyoto Encyclopedia Genes Genomes (KEGG) performed Metascape. Gene-miRNA constructed miRTarBase NetworkAnalyst, miRNA functions annotated miEAA. An AD mouse model induced DNCB established evaluate oil's therapeutic efficacy, influence inflammatory markers, Fifteen common found be crucial pathogenesis. The PPI network, revealed interactions among 13 nodes 42 edges, Cytoscape highlighting 10 core targets. GO KEGG analyses significant biological processes like cell migration response regulation, pathways such as IL-17 signaling. suggested may regulate miRNAs hsa-mir-124-3p hsa-let-7b-5p. Experimental results showed that significantly improved symptoms mice, reduced IL-4 IL-13 levels, decreased p-PI3K, p-PI3K/PI3K, p-Akt, p-Akt/Akt expression, inhibiting activation. exerts multi-target, multi-pathway effects AD, potentially through suppressing Th2-mediated immune responses pathway, suggesting novel avenues for treatment strategies.

Language: Английский

---

Combining Advanced Targeted Therapy in Inflammatory Bowel Disease: Current Practice and Future Directions

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 590 - 590

Published: Jan. 17, 2025

Background/Objectives: Despite the increasing number of available medications, a significant proportion IBD patients fail to achieve current therapeutic targets. Uncontrolled has impact on patients' quality life and overall costs for healthcare system. Given complex pathophysiology IBD, Combined Advanced Targeted Therapy (CATT), involving combination biologics/small molecules, appears have biological plausibility is gaining interest. The aim this narrative review provide evidence regarding CATT in propose future developments field. Methods: Relevant literature was searched with pertinent MeSH terms most important database. Results: Available provides encouraging results efficacy effectiveness, an acceptable safety profile. may represent solution "difficult-to-treat" or concomitant immune-mediated inflammatory diseases. However, data are restricted by low level short follow-up. Conclusions: There no concluding superiority one therapy over another. Various schemes could be applied near future. Further studies needed recommendations integrate strategy into everyday clinical practice.

Language: Английский

---