Plasma oxidative stress marker levels related to functional brain abnormalities in first-episode drug-naive major depressive disorder

Psychiatry Research, Journal Year: 2024, Volume and Issue: 333, P. 115742 - 115742

Published: Jan. 16, 2024

Language: Английский

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A brain-targeted and ROS-responsive natural polysaccharide nanogel for enhancing antidepressant therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160719 - 160719

Published: Feb. 1, 2025

Language: Английский

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Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(1), P. 176 - 196

Published: March 5, 2024

Major depressive disorder (MDD), a prevalent mental illness, is marked by complex mixture of biological factors. This review focuses on the roles oxidative stress, tryptophan-serotonin metabolism, brain-derived neurotrophic factor (BDNF), and hypothalamic–pituitary–adrenal (HPA) axis in MDD’s pathophysiology. Oxidative defined as an imbalance between pro-oxidants antioxidants, closely linked to neurobiological changes. The tryptophan (TRP)-/serotonin (5-HT) metabolic pathway also known be crucial mood regulation, with its dysregulation being central aspect MDD. Additionally, BDNF, key for neuronal growth plasticity, often shows alterations MDD patients, supporting role disorder’s progression. Furthermore, HPA axis, which manages stress response, frequently disrupted MDD, further contributing pathology. In addition exploring these mechanisms, this explores pharmacotherapy including new advances. These advancements treatment strategies are managing effectively. Understanding mechanisms latest pharmacological interventions essential developing more effective treatments

Language: Английский

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Association between the triglyceride glucose index and depression: a meta-analysis

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

Background Obesity and diabetes have been associated with depressive symptoms. The aim of this systematic review meta-analysis was to evaluate the association between triglyceride glucose index (TyG index) a novel indicator insulin resistance (IR) depression in adult population. Methods Relevant observational studies were acquired through comprehensive searches Medline, Web Science, Embase, Wanfang, China National Knowledge Internet databases. To account for heterogeneity, random-effects model employed combine findings. Additionally, multiple subgroup analyses conducted assess impact various study characteristics on outcome. Results comprised eight datasets from six cross-sectional studies, encompassing total 28,973 adults. pooled findings suggested that subjects high TyG index, compared those low higher prevalence (odds ratio [OR]: 1.41, 95% confidence interval (CI): 1.28–1.56, p< 0.001; I 2 = 19%). Sensitivity analyses, by omitting one dataset at time, showed consistent results (OR: 1.39–1.45, p <0.05). Further participants aged <50 years old ≥50 old, men women, different cutoff values methods diagnosis (for each difference, >0.05). Conclusion A may be

Language: Английский

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Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders—An Overview of Experimental Evidence

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2856 - 2856

Published: Aug. 26, 2024

The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological and behavioral disorders. protective mechanisms resveratrol, particularly anxiety-related stress well documented. However, less has given to the side effects resveratrol. This review explores not only underlying anxiolytic but also that may lead increased anxiety following treatment. Understanding these is crucial for enhancing efficacy managing disorders associated with PTSD.

Language: Английский

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Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 159 - 173

Published: April 3, 2024

Brain-derived neurotrophic factor is a key in stress adaptation and avoidance of social behavioral response. Recent studies have shown that brain-derived expression stressed mice brain region–specific, particularly involving the corticolimbic system, including ventral tegmental area, nucleus accumbens, prefrontal cortex, amygdala, hippocampus. Determining how participates processing different regions will deepen our understanding psychopathology. In this review, we discuss regulation stress-sensitive closely related to pathophysiology depression. We focused on associated molecular pathways neural circuits, with special attention factor–tropomyosin receptor kinase B signaling pathway area–nucleus accumbens dopamine circuit. determined stress-induced alterations levels are likely nature, severity, duration stress, especially above-mentioned system. Therefore, BDNF might be biological indicator regulating stress-related processes various regions.

Language: Английский

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Research Hotspots and Trends in the Antioxidant Effects of Acupuncture: A Bibliometric analysis from 2003 to 2024

Complementary Therapies in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103123 - 103123

Published: Jan. 1, 2025

Oxidative stress is an important factor mediating the pathologic progression of many diseases. In recent years, antioxidant effects acupuncture have been gradually confirmed. However, bibliometric analysis in this field, which still lacking. This study aimed to explore current state research and trends regulating oxidative by using methods. Articles pertaining were systematically retrieved from Web Science Core Collection database, encompassing temporal scope inception September 6, 2024. Countries, publications, authors, co-citations, keywords visualized analyzed CiteSpace, VOSviewer, R software. A total 438 articles published with number increasing yearly. Chinese scholars constitute a significant force domain field. Beijing University Traditional Medicine institution highest publications. Cunzhi Liu (17) author The journals most publications (39) citations (652) are EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. Basic main type research. Both co-cited literature keyword examination indicated neurological disorders, including Alzheimer's disease, Parkinson's stroke, as prominent domains. Electroacupuncture common intervention. Pain inflammation may be trend area. summarises disease mapping some mechanisms acupuncture's effects. Neurological disorders such vascular dementia, stroke major areas direction for future

Language: Английский

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Estrogen Metabolites and H202 - Missing Elements in the Pathophysiology of Treatment-Resistant Depression?

Published: Jan. 1, 2025

Language: Английский

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Combined Effects of Particulate Matter Exposure and Exercise Training on Neuroplasticity-Related Growth Factors and Blood–Brain Barrier Integrity

Atmosphere, Journal Year: 2025, Volume and Issue: 16(2), P. 220 - 220

Published: Feb. 15, 2025

Particulate matter (PM) negatively impacts brain health, while exercise training can mitigate these effects and promote health. However, the effect of interaction between PM exposure on health remains insufficiently explored. This study investigated neuroplasticity-related growth factors blood–brain barrier (BBB) integrity. Forty male C57BL/6 mice were randomly assigned to four groups as follows: control (CON, n = 10), (PM, (EX, with (PMEX, 10). interventions conducted over 8 weeks. The group showed significantly elevated levels malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), S100 calcium-binding protein β (S100β), neuron-specific enolase (NSE) (p < 0.05) reduced superoxide dismutase (SOD), insulin-like factor-1 (IGF-1), brain-derived neurotrophic factor (BDNF), vascular endothelial (VEGF) compared CON EX groups. Conversely, demonstrated MDA, IL-6, TNF-α, S100β, NSE enhanced SOD, IGF-1, BDNF, VEGF group. PMEX exhibited attenuated benefits, showing higher lower SOD IGF-1 These findings suggest that induces oxidative stress, inflammation, BBB disruption downregulating factors. Exercise mitigates adverse by enhancing antioxidant activity, reducing upregulating factors, preserving protective may be partially diminished under conditions exposure.

Language: Английский

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Estrogen metabolites and H202 - missing elements in the pathophysiology of treatment-resistant depression?

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103547 - 103547

Published: Feb. 20, 2025

The pathogenesis of depression is complex and heterogeneous, the management this disease remains unsatisfactory, so mechanisms therapeutic strategies are constantly being sought. This study aimed to determine potential role estrogen metabolites in treatment-resistant (TRD) based on determination concentrations estrogens their hydrogen peroxide (H202) biological material patients with TRD. In study, we observed for first time an association between unbalanced metabolism elevated H202 levels TRD patients. Reduced 2-methoxyestradiol (2-ME2), 17α-estradiol (α-E2) 17β-estradiol (β-E2) may be due abnormal toward neurotoxic semiquinones quinones which a as yet undescribed mechanism responsible generating oxidative stress (OS)

Language: Английский

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