Targeting COVID-19 (SARS-CoV-2) main protease through phytochemicals of Albizia lebbeck: molecular docking, molecular dynamics simulation, MM–PBSA free energy calculations, and DFT analysis DOI

Nasiruddin Nalban,

Manish Wanjari, Rasika Kolhe

et al.

Journal of Proteins and Proteomics, Journal Year: 2024, Volume and Issue: 15(2), P. 197 - 208

Published: April 26, 2024

Language: Английский

Emerging Therapeutic Potential of Polyphenols from Geranium sanguineum L. in Viral Infections, Including SARS-CoV-2 DOI Creative Commons
Silviya Abarova, Ralitza Alexova, Stela Dragomanova

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 130 - 130

Published: Jan. 19, 2024

The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of polyphenol extracts derived from Geranium sanguineum L. These exhibit potential in hindering viral replication by inhibiting enzymes like DNA polymerase reverse transcriptase. properties G. seem to complement its immunomodulatory effects, contributing infection resolution. While preclinical studies on suggest effectiveness against COVID-19, there is still a lack clinical evidence. Therefore, polyphenols extracted this herb warrant further investigation as alternative for preventing treating COVID-19 infections.

Language: Английский

Citations

3
NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2 DOI Creative Commons

Mohsen Nakhaei,

Zohreh‐al‐sadat Ghoreshi, Mohammad Rezaei Zadeh Rukerd

et al.

Mediterranean Journal of Hematology and Infectious Diseases, Journal Year: 2023, Volume and Issue: 15(1), P. e2023059 - e2023059

Published: Oct. 16, 2023

Mutation in the genome of SARS-CoV-2 may play a role immune evasion, pathogenicity, and speed its transmission. Our investigation aimed to evaluate mutations that exist NSP2.RNA was extracted from nasopharyngeal swabs 100 COVID-19 patients. RT-PCR performed on all samples using NSP2-specific primers. Following gel electrophoresis, bands were cut, purified, sequenced Sanger method. After sequencing, 90 sequences could be used for further analysis. Bioinformatics analysis conducted investigate effect protein structure, stability, prediction homology models, phylogeny tree.The patients' mean age 51.08. The results revealed 8 17 NSP2 (R207C, T224I, G262V, T265I, K337D, N348S, G392D, I431M) missense. One deletion also found NSP2. Among missense studied, K337D G392D increased structural stability while others decreased it. homology-designed models demonstrated homologies comparable Wuhan-HU-1 virus.Our study suggested modulate NSP2, tracking viral evolution should implemented vaccine development updated.

Language: Английский

Citations

4
Identification of new inhibitors for the avian H1N1 virus through molecular docking and dynamic simulation approaches DOI
Md. Rezaul Islam,

Shankar Sharma,

Sk Yeasir Arafat

et al.

Journal of the Indian Chemical Society, Journal Year: 2024, Volume and Issue: 101(10), P. 101274 - 101274

Published: July 20, 2024

Language: Английский

Citations

1
Myricetin causes site-specific DNA damage via reactive oxygen species generation by redox interactions with copper ions DOI

Yuichiro Hirao,

Hatasu Kobayashi,

Yurie Mori

et al.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, Journal Year: 2023, Volume and Issue: 891, P. 503694 - 503694

Published: Sept. 18, 2023

Language: Английский

Citations

2
Synthesis, characterization, cytotoxicity, and antiviral activity of new coumarin analogues against coronavirus DOI Creative Commons
Mohammad Auwal Sa’ad, Manickam Ravichandran, Pattabhiraman Lalitha

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 10, P. 101702 - 101702

Published: Aug. 1, 2024

Coronaviruses have emerged as a global health challenge, with the recent outbreak of SARS-CoV-2 affecting more than 600 million individuals worldwide. While vaccination remains central preventive approach, addressing involves antiviral drugs, monoclonal antibodies, and corticosteroids. Research indicates that coumarin exhibits potent properties. Therefore, this study aimed to investigate properties newly synthesized analogues (NCA) against coronaviruses. The involved synthesis NCAs through esterification, hydrazination, imination, cyclo-condensation reactions, followed by their characterization using FTIR, NMR, Mass Spectrometry. Cell viability analysis was conducted HEK-293 cells, viral replication inhibition activity OC43 assessed plaque assays. Infectious Bronchitis Virus (IBV) evaluated based on mortality rate, lesion development, RNA load suppression. successfully elucidated structures. assay demonstrated ability effectively inhibit replication. Analysis qRTPCR confirmed decrease in following NCA treatment. Immunofluorescence assays also showed reduction infection presence NCAs. Evaluation cytotoxicity cells indicated exhibited favourable safety profile while inhibiting IBV These findings highlight promising activities coronavirus infection.

Language: Английский

Citations

0
Antiviral activity of Polygonum aviculare extract against murine norovirus as norovirus surrogate and its application in model food1 DOI Creative Commons

Ji-Hye Han,

Nari Lee, Sung Wook Choi

et al.

LWT, Journal Year: 2024, Volume and Issue: unknown, P. 116887 - 116887

Published: Oct. 1, 2024

Language: Английский

Citations

0
Myricetin as a Promising Flavonoid with Multitargeted Biological Activity DOI Creative Commons
A. Chiriapkin

Juvenis scientia, Journal Year: 2024, Volume and Issue: 10(1), P. 5 - 18

Published: Feb. 29, 2024

Polyphenolic compounds are widely represented in objects of plant origin and have diverse types biological activity. Since ancient times, the beneficial effect various galenic preparations on human health has been known, they acted as almost only source treatment for diseases improvement well-being. The major components many herbal medicines flavonoids, which by both individual structures related carbohydrate components. One flavonoids plants is myricetin. This molecule belongs to one most hydroxylated a wide range therapeutic possibilities. modern review summarizes latest information myricetin’s antioxidant, antidiabetic, anti-inflammatory, antiviral, neuroprotective, antitumor, hepatoprotective activity its functioning cardiovascular system. From results studying myricetin, it obvious that polyphenolic compound promising substance prevention complex therapy diseases. It should be noted myricetin can considered potential candidate targeted design new substances with more pronounced pharmacological effects. In addition, flavonoid finds application biologically active additives food products, expands prospects research.

Language: Английский

Citations

0
Targeting COVID-19 (SARS-CoV-2) main protease through phytochemicals of Albizia lebbeck: molecular docking, molecular dynamics simulation, MM–PBSA free energy calculations, and DFT analysis DOI

Nasiruddin Nalban,

Manish Wanjari, Rasika Kolhe

et al.

Journal of Proteins and Proteomics, Journal Year: 2024, Volume and Issue: 15(2), P. 197 - 208

Published: April 26, 2024

Language: Английский

Citations

0