Review of the therapeutic potential of Forsythiae Fructus on the central nervous system: Active ingredients and mechanisms of action

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117275 - 117275

Published: Oct. 4, 2023

Traditional Chinese medicine has gained significant attention in recent years owing to its multi-component, multi-target, and multi-pathway advantages treating various diseases. Forsythiae Fructus, derived from the dried fruit of Forsythia suspensa (Thunb.) Vahl, is one such traditional with numerous vivo ex therapeutic effects, including anti-inflammatory, antibacterial, antiviral properties. Fructus contains more than 200 chemical constituents, forsythiaside, forsythiaside A, B, isoforsythiaside, forsythin, phillyrin being most active ingredients. exerts neuroprotective effects by modulating pathways, oxidative stress, anti-inflammation, NF-κB signaling, 2-AG, Nrf2 acetylcholinesterase, PI3K-Akt ferroptosis, gut-brain axis, TLR4 endoplasmic reticulum PI3K/Akt/mTOR PPARγ signaling pathway. This review aims highlight potential on central nervous system summarize current knowledge ingredients their different pathways involved neuroprotection. In this review, we conducted a comprehensive search databases (PubMed, Google Scholar, Web Science, China Knowledge Resource Integrated, local dissertations books) up until June 2023 using key terms as forsythia suspensa, phillyrin, Alzheimer′s disease, Parkinson's ischemic stroke, intracerebral hemorrhage, traumatic brain injury, aging, herpes simplex virus encephalitis. Our findings indicate that own have demonstrated promising Future clinical studies should be establish precise dosage standard guidelines for effective application treatment neurological disorders.

Language: Английский

Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis

Immunologic Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Language: Английский

Evaluation of Genotoxicity and Teratogenicity of Phillyrin

Toxicon, Journal Year: 2024, Volume and Issue: 249, P. 108080 - 108080

Published: Aug. 26, 2024

Language: Английский