Effects of five cannabis oils with different CBD:THC ratios and terpenes on hypertension, dyslipidemia, hepatic steatosis, oxidative stress, and CB1 receptor in an experimental model DOI
Valentina Degrave, Michelle Berenice Vega Joubert,

Camila Fillipa

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is a common disorder caused by oxidative stress and dysregulation of lipid metabolism. The endocannabinoid system (ECS), particularly the type 1 cannabinoid (CB1) receptor, plays crucial role in NAFLD progression. Cannabinoids, such as cannabidiol (CBD) tetrahydrocannabinol (THC), along with terpenes, beta-myrcene d-limonene, have shown potential therapeutic effects on health, reducing modulating This study aimed to analyse five cannabis oils (COs), each different CBD:THC ratios terpenes content, hypertension, dyslipidemia, hepatic steatosis, stress, CB1 receptor expression an experimental model induced sucrose-rich diet (SRD) Wistar rats for 3 weeks. Methods: Male were fed either a: 1) reference (RD; standard commercial laboratory diet) or 2) 7 SRD+CO following: 3) SRD+THC; 4) SRD+CBD; 5) SRD+CBD:THC 1:1; 6) 2:1; 7) 3:1. COs administered orally at dose 1.5 mg total cannabinoids/kg body weight daily. content all used was determined. found beta-myrcene, terpinolene, linalool, beta-caryophyllene, alpha-humulene, (-)-guaiol, (-)-alpha-bisabolol. During period, weight, food intake blood pressure measured. Serum glucose, triglyceride, cholesterol, uric acid, alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (AP) levels evaluated. Liver tissue histology, activity score (NAS), triglyceride cholesterol lipogenic enzyme activities, related mitochondrial acid oxidation, reactive oxygen species (ROS), thiobarbituric substance (TBARS), antioxidant activities also Results: The results showed that SRD-fed developed damage, peroxidation, stress. accompanied upregulation expression. CBD-rich CO, 1:1 ratio CO; 2:1 CO 3:1 antihypertensive properties. THC-rich greatest beneficial against steatosis damage. All exhibited tissue. associated normal Conclusions: This demonstrated COs, can effectively reduce damage SRD-induced NAFLD. higher proportion CBD their composition These findings suggest especially those may represent promising approach managing preventing its progression more severe disease.

Language: Английский

Unlocking the Therapeutic Potential of Patchouli Leaves: A Comprehensive Review of Phytochemical and Pharmacological Insights DOI Creative Commons
Isack Ibrahim Mrisho, Elshan Musazade,

Haobo Chen

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(7), P. 1034 - 1034

Published: March 26, 2025

Plant-based products play an increasingly vital role in the pharmaceutical industry, including Pogostemon cablin (Blanco) Benth. (patchouli), which is notable for its rich history and extensive use traditional medicine. Patchouli has a longstanding historical as remedy wide range of health conditions, colds, fevers, headaches, inflammation, digestive disorders, insect snake bites. Comprehensive phytochemical studies have revealed that patchouli leaves contain diverse valuable bioactive compounds, notably alcohol, β-patchoulene, pogostone, α-bulnesene, β-caryophyllene. Recent demonstrated exhibit various pharmacological properties, anti-oxidant, anti-inflammatory, antimicrobial, antidepressant, anticancer effects. Despite robust knowledge, specific therapeutic applications require scientific validation standardization their compounds. This review provides comprehensive overview existing literature on composition, underlying mechanisms action essential oil (PEO) plant extracts obtained from leaves. It offers detailed insights into potential applications, aiming to inform guide future research across multiple medical disciplines. Ultimately, this underscores need further validate develop medicinal leaves, providing foundation healthcare advancements.

Language: Английский

Citations

0
Effects of five cannabis oils with different CBD:THC ratios and terpenes on hypertension, dyslipidemia, hepatic steatosis, oxidative stress, and CB1 receptor in an experimental model DOI
Valentina Degrave, Michelle Berenice Vega Joubert,

Camila Fillipa

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) is a common disorder caused by oxidative stress and dysregulation of lipid metabolism. The endocannabinoid system (ECS), particularly the type 1 cannabinoid (CB1) receptor, plays crucial role in NAFLD progression. Cannabinoids, such as cannabidiol (CBD) tetrahydrocannabinol (THC), along with terpenes, beta-myrcene d-limonene, have shown potential therapeutic effects on health, reducing modulating This study aimed to analyse five cannabis oils (COs), each different CBD:THC ratios terpenes content, hypertension, dyslipidemia, hepatic steatosis, stress, CB1 receptor expression an experimental model induced sucrose-rich diet (SRD) Wistar rats for 3 weeks. Methods: Male were fed either a: 1) reference (RD; standard commercial laboratory diet) or 2) 7 SRD+CO following: 3) SRD+THC; 4) SRD+CBD; 5) SRD+CBD:THC 1:1; 6) 2:1; 7) 3:1. COs administered orally at dose 1.5 mg total cannabinoids/kg body weight daily. content all used was determined. found beta-myrcene, terpinolene, linalool, beta-caryophyllene, alpha-humulene, (-)-guaiol, (-)-alpha-bisabolol. During period, weight, food intake blood pressure measured. Serum glucose, triglyceride, cholesterol, uric acid, alanine aminotransferase (ALT), aspartate (AST), alkaline phosphatase (AP) levels evaluated. Liver tissue histology, activity score (NAS), triglyceride cholesterol lipogenic enzyme activities, related mitochondrial acid oxidation, reactive oxygen species (ROS), thiobarbituric substance (TBARS), antioxidant activities also Results: The results showed that SRD-fed developed damage, peroxidation, stress. accompanied upregulation expression. CBD-rich CO, 1:1 ratio CO; 2:1 CO 3:1 antihypertensive properties. THC-rich greatest beneficial against steatosis damage. All exhibited tissue. associated normal Conclusions: This demonstrated COs, can effectively reduce damage SRD-induced NAFLD. higher proportion CBD their composition These findings suggest especially those may represent promising approach managing preventing its progression more severe disease.

Language: Английский

Citations

0