Protective and Therapeutic Effects of Orlistat in Combination with Elettaria cardamomum “Cardamom” Extract on Learning, Memory, Anxiety, and Neuroinflammation in Obese Mice

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 263 - 263

Published: Feb. 4, 2025

Introduction and Objective: Obesity has increased worldwide, existing anti-obesity medications have treatment limitations that diminish their overall benefits. This study aimed to investigate the effects of orlistat in combination with Elettaria cardamomum “Cardamom” (CAR) extract on working memory, recognition anxiety, inflammation within hippocampal tissue. Methods: Mice were categorized into two groups: a control group (CD) cafeteria diet (CAF) induced obesity for 10 weeks. The groups then subdivided CAF treated (CAF-ORL), (CAF-ORL-CARD), continued CAF. CAF-ORL received at dosage mg/kg/day four weeks, while CAF-ORL-CARD 500 mg/kg CAR via oral gavage. In 14th week, various assessments conducted, including novel object (NOR) test, Y maze marble-burying test (MBT), open-field TNF-α levels hippocampus. Result: tissue elevated compared CD (p < 0.01), whereas exhibited reduced 0.01). Moreover, significantly lower than index was notably higher 0.01) However, there no changes > 0.05). Conclusions: Orlistat combined positive neuroinflammation suggesting this may offer potential therapeutic benefits cognitive impairments dysfunction associated obesity.

Language: Английский

Exploring the antidiabetic effect of various therapeutic essential oils synergistically with repaglinide

Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 103721 - 103721

Published: March 1, 2025

Language: Английский