Comparison of the application value of contrast-enhanced ultrasound and contrast-enhanced CT in puncture biopsy of peripheral pulmonary lesions

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 30, 2025

Objective This study assesses the clinical utility of contrast - enhanced ultrasound (CEUS) in comparison to computed tomography (CECT) context peripheral lung mass biopsy. The overarching objective is establish robust benchmarks that can guide evidence based decision making field pulmonary interventional procedures. Methods A 420 patients admitted our hospital from January 2019 December 2022 who underwent biopsy using two different guidance methods, including 196 cases CEUS-guided group and 224 CECT-guided group. average number pleural punctures, puncture time, satisfaction with first specimen, diagnostic accuracy complication rate were compared between methods. Results ① Compared CECT group, required fewer punctures (2.5 vs. 4.1 times) shorter time (24 minutes 42 minutes) on average, difference was statistically significant (P<0.001). ② In terms complications, incidence pneumothorax (3.1% 8%) lower CEUS while bleeding (1.5% 3.1%) had no groups ③ When diameter lesion <3 cm, specimen are than those (71.0% 88.3%, 64.5% 86.7%). (3 ~ 6cm), higher (98.6% 89.6%, 95.8% 85.2%), above differences significant; but when >6cm, there Conclusion better reducing shortening pneumothorax, especially suitable for diagnosis medium-sized lesions. However, lesions less 3 cm diameter, demonstrated accuracy. suggests performance be optimized by selecting appropriate techniques size risk complications.

Language: Английский

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Radial Endobronchial Ultrasound-guided Transbronchial Cryobiopsy versus Forceps Biopsy for the Diagnosis of Solitary Pulmonary Nodules: A Prospective Randomised Trial

The Open Respiratory Medicine Journal, Journal Year: 2023, Volume and Issue: 17(1)

Published: Oct. 10, 2023

Background: Improvements in pulmonary diagnostic imaging and the development of lung cancer screening are increasing prevalence Solitary nodules (SPNs). Fluoroscopically guided radial endobronchial ultrasound (EBUS) with transbronchial forceps biopsy (TB-FB) has been conventional method. Transbronchial cryobiopsy (TB-CB) is an alternative We sought to compare for diagnosis SPNs. Methods: A prospective, single-centre, randomised controlled trial was conducted at Royal Adelaide Hospital (RAH). Patients SPNs were either 5 biopsies or one cryobiopsy. Complete blinding investigators participants not possible, as required general anaesthesia. The primary outcome yield secondary outcomes specimen size, subsets challenging access safety. Results: overall 28 enrolled subjects 76.8%(22/28). 91.7% (11/12 patients) 68.8% (11/16 (p=0.14). Median sizes consistently larger arm 7.0mm compared 2.5mm(p<0.0001). An eccentric EBUS image signalling probe adjacent nodule occurred 4/28 cases, TB-CB confirmed a 3/3 this arm. There no major complications technique. Conclusion: under guidance fluoroscopy facilitates specimens without significant increase complications. Further research confirm effect on yield; however, our study supports role small, nodule-adjacent biopsies. Clinical Trial Registration Number: Reference number R20160213(HREC/16/RAH/37).

Language: Английский

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Balloon Dilatation for Bronchoscope Delivery in a Swine Model: A Novel Technique for Ultra-Peripheral Lung Field Access and Accurate Biopsy

Respiration, Journal Year: 2024, Volume and Issue: 103(4), P. 205 - 213

Published: Jan. 1, 2024

<b><i>Introduction:</i></b> In transbronchial biopsy of peripheral pulmonary lesions, the bronchoscope can reach only a limited depth due to progressive narrowing bronchi, which may reduce diagnostic rate. This study examined balloon dilatation for delivery (BDBD) technique, employing novel device enhance bronchoscopy into lung areas. <b><i>Methods:</i></b> Anaesthetised swine served as our primary model. Using computed tomography (CT) scans, we positioned virtual targets characterised by positive bronchus sign and diameter 20 mm beneath pleura. The was navigated along pathways determined from CT images. We performed when bronchial obstructed progress assess whether would enable enter further periphery. <b><i>Results:</i></b> established 21 on scans. An average 12.1 branches were identified scans; however, without BDBD allowed access an 6.7 branches. Based 72 dilatations with 3.0-mm or 4.0-mm ultra-thin bronchoscopes, there increased 3.43 5.14 per route, respectively, no significant complications. able planned location all pathways, mean final bronchoscopic endpoints at distance 14.7 Post-procedure confirmed accuracy. <b><i>Conclusion:</i></b> technique flexible fields, could potentially allow more accurate interventions targets.

Language: Английский

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Effect of forceps biopsy on bronchial washing results in patients with endoscopically visible lung tumors

World Academy of Sciences Journal, Journal Year: 2024, Volume and Issue: 6(6)

Published: Aug. 7, 2024

Enhancing diagnostic bronchoscopy techniques is paramount for lung cancer detection; bronchial washing one of those modalities. However, there controversy regarding the optimum sequence performing this procedure in relation to biopsy. The present study aimed assess most effective biopsy diagnosing cancer. was a single‑center prospective carried out over period 18 months. included patients >18 years age with mass or suspected lesions on chest computed tomography and an endoscopically visible mass. They were randomly assigned before forceps group after group. Bronchial performed under cytological histopathological analysis, respectively. 50 mean 72 years. males comprised 36 (72%) patients. pre‑biopsy wash (pre‑BW) yielded positive results 21 (42%) patients, post‑biopsy (post‑BW) 23 (46%) revealed that 22 (44%) cases squamous cell carcinoma, (36%) adenocarcinoma, 8 (16%) small 1 (2%) acinar not malignant. A comparison pre‑BW post‑BW statistically significant difference between them (P‑value <0.001). Pre- post-BW may affect yield outcomes tumors. additional research, such as studies using larger sample sizes meta-analyses, required determine efficacy approach.

Language: Английский

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Improved diagnostic yield of peripheral pulmonary malignant lesions with emphysema using a combination of radial endobronchial ultrasonography and rapid on-site evaluation

BMC Pulmonary Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 20, 2024

This is a retrospective cohort study from single center of Chest Medical District Nanjing Brain Hospital Affiliated to University, Jiangsu Province, China. It was aim evaluate the diagnostic value radial endobronchial ultrasound (R-EBUS) combination with rapid on-site evaluation (ROSE) guided transbronchial lung biopsy (TBLB) for peripheral pulmonary lesions in patients emphysema.

Language: Английский

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Diagnostic efficacy of endobronchial ultrasound-guided transbronchoscopic lung biopsy for identifying tuberculous nodules

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 26, 2024

Microbiological diagnosis of pulmonary tuberculosis (PTB) is hampered by a low pathogen burden, compliance and unreliable sputum sampling. Although endobronchial ultrasound-guided transbronchoscopic lung biopsy (EBUS-TBLB) has been found to be useful for the assessment intrapulmonary nodules in adults, few data are available clinical tuberculosis. Here, we evaluated EBUS-TBLB as diagnostic procedure adult patients with radiologically suspected tuberculous nodules. This was retrospective analysis admitted between January 2022 2023 at Hangzhou Red Cross Hospital. All underwent EBUS-TBLB, samples were obtained during hospitalization. tested Mycobacterium using acid‒fast smears, Bactec MGIT 960, Xpert MTB/RIF, next-generation sequencing (NGS), DNA (TB‒DNA) RNA (TB‒RNA). The concordance different methods analysed via kappa analysis. efficacy PTB ROC curve. A total 107 included this study. Among them, 86 diagnosed overall rate 80.37%. In addition, 102 enrolled had benign lesions, only 5 tumours. Univariate revealed that related location probe. consistency curve NGS highest results (agreement = 78.50%, κ 0.558) (AUC 0.778). MTB/RIF + 84.11%, 0.667) 0.826). sensitive safe method pathological combined can used initial PTB.

Language: Английский

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Diagnostic performance of rapid on‐site evaluation during bronchoscopy for lung cancer: A comprehensive meta‐analysis

Cancer Cytopathology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Lung cancer is the leading cause of cancer-related mortality worldwide. Screening high-risk populations for lung with low-dose computed tomography (LDCT) reduces mortality. Bronchoscopy a diagnostic procedure used to monitor patients suspected having after LDCT. Rapid on-site evaluation (ROSE) can improve accuracy endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), although its value remains unclear. In this meta-analysis, authors evaluated ROSE during bronchoscopy.

Language: Английский

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