Composites Communications, Journal Year: 2024, Volume and Issue: unknown, P. 102239 - 102239
Published: Dec. 1, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575
Published: Sept. 7, 2024
Language: Английский
Citations
5
IOP Conference Series Earth and Environmental Science, Journal Year: 2025, Volume and Issue: 1439(1), P. 012034 - 012034
Published: Jan. 1, 2025
Abstract This research aims to develop an optimal hydrogel formula using Design Expert 13.0 and the Simplex Lattice (SLD) method. The combines Centella asiatica Moringa oleifera extracts with carbopol 940 as a gelling agent triethanolamine (TEA) alkalizer. Hydrogels were chosen due their ease of use, cooling effect, superior biocompatibility compared other topical formulations like ointments or creams. study focused on optimizing meet Indonesian National Standards (SNI). After eight trials SLD method, physical evaluations conducted, including organoleptic tests, pH measurements, spreadability, viscosity tests. contained 0.6% Carbopol 0.4% TEA, validated three replications. exhibited deep green color, distinctive extract aroma, thick texture, meeting SNI standards average 7.1±0.29, spreadability 5.7±0.21 cm, 20,080±0.35 cPs. Stability tests confirmed its quality after cycling centrifugal evaluations. promotes sustainable eco-friendly practices by utilizing natural extracts, reducing reliance synthetic chemicals, contributing environmentally conscious drug innovations. development such hydrogels aligns sustainability goals, offering biodegradable safe that minimize environmental impact.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Harnessing cross‐species regenerative cues to direct human potential is increasingly recognized as an excellent strategy in medicine, particularly for addressing the challenges of impaired wound healing aging populations. The skin mucus Andrias davidianus plays a critical role self‐protection and tissue repair, yet fundamental factors mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from secretion (SAGs) serve potent mediators angiogenesis inflammatory remodeling, facilitating efficient diabetic wounds. Mechanistic studies reveal SAGs promote macrophage polarization toward anti‐inflammatory pro‐regenerative phenotype (CD206 + /Arg1 ) via glucolipid metabolic reprogramming. This process suppresses excessive inflammation enhances expression VEGF IL‐10 create facilitative microenvironment regeneration. Additionally, develops SAGs‐GelMA composite microspheres address multiple stages healing, including rapid hemostasis, exudate control, activation endogenous processes. engineered approach significantly improves scarless wounds by recruitment reparative macrophages. findings offer new insights into highlight therapeutic application repair.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143136 - 143136
Published: April 1, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101780 - 101780
Published: April 17, 2025
Chronic diabetic wounds remain a significant clinical challenge due to persistent bacterial infections, oxidative stress, impaired angiogenesis, and mitochondrial dysfunction. Traditional therapies often fail address these interrelated pathological factors, highlighting the urgent need for innovative solutions. Here, we present Mn-ZIF@GOx/BC (MZGB) hydrogel system, where Mn-ZIF@GOx (MZG) nanozymes are successfully integrated into cellulose (BC) via hydrogen bonding electrostatic interactions. The MZGB lowers wound pH by oxidizing excess glucose gluconic acid. It exhibits strong ROS scavenging capabilities through its superoxide dismutase catalase-like activities, while simultaneously providing oxygen. By restoring redox homeostasis, it protects function enhances cellular energy metabolism. reprogramming macrophages, creates favorable immune microenvironment, significantly promoting angiogenesis paracrine mechanisms. This facilitates cell-to-cell communication, forming positive feedback loop. Moreover, demonstrates ROS-independent antibacterial properties. BC ensures adhesion moisture regulation, protective barrier maintaining an optimal environment. multifunctional represents promising nanotherapeutic approach efficiently treating precisely regulating microenvironment.
Language: Английский
Citations
0
World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)
Published: April 24, 2025
Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.
Language: Английский
Citations
0
Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.
Language: Английский
Citations
0
Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2669 - 2686
Published: Nov. 1, 2024
The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. steady-state regular changes microenvironment around wound provide good conditions for healing achieve a dynamic complex process healing.The pH value ionic environment composed variety ions important factors affecting microenvironment, there direct or indirect connections between them. Abnormalities pH, ion concentrations, channels skin tissue may be one reasons difficulty healing. Currently, different wound-dressing applications have been developed based on efficacy ions. Here, effect wounds, concentrations calcium (Ca
Language: Английский
Citations
0
Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1869(1), P. 130735 - 130735
Published: Dec. 7, 2024
Language: Английский
Citations
0
Composites Communications, Journal Year: 2024, Volume and Issue: unknown, P. 102239 - 102239
Published: Dec. 1, 2024
Language: Английский
Citations
0