Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis DOI
Xiaoqing Liu, Lianghui Huang,

Enguang Wu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(41)

Published: Oct. 29, 2024

Abstract Ulcerative colitis (UC) is a chronic non‐specific inflammatory disease of the intestines with high prevalence. Polymer‐prepared nanoparticles are well‐targeted, highly biocompatible, and have potential for personalized therapy. Polymer able to achieve localized therapy through their unique design. First, this review compares advantages disadvantages natural synthetic polymeric materials as well describes application in UC Then, preparation, characterization methods, current challenges common polymer presented. Next, one‐by‐one examples nanoparticle‐targeted drug delivery strategies treatment In addition, nanoparticle‐based therapeutic approaches UC, including anti‐inflammatory therapies, reactive oxygen species scavenging intestinal flora modulation Finally, future research directions discussed identified. The aim paper provide valuable references guidance researchers design develop novel therapies.

Language: Английский

Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development DOI Creative Commons

Elena Gardey,

Johannes C. Brendel, Andreas Stallmach

et al.

Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.

Language: Английский

Citations

0
Nano-Phytoconstituents: Recent Advances, Regulatory Insights, Challenges, and Future Horizons DOI
M H Miran Beygi, Fatemeh Oroojalian, Sercan Karav

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106908 - 106908

Published: April 1, 2025

Language: Английский

Citations

0
Intratracheal delivery of macrophage targeted Celastrol-loaded PLGA nanoparticles for enhanced anti-inflammatory efficacy in acute lung injury mice DOI

Yinlian Yao,

Shilong Fan,

Yinqiang Fan

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 114511 - 114511

Published: Sept. 1, 2024

Language: Английский

Citations

2
Application of Polymers as Drug Nanocarriers in the Oral Treatment of Ulcerative Colitis DOI
Xiaoqing Liu, Lianghui Huang,

Enguang Wu

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(41)

Published: Oct. 29, 2024

Abstract Ulcerative colitis (UC) is a chronic non‐specific inflammatory disease of the intestines with high prevalence. Polymer‐prepared nanoparticles are well‐targeted, highly biocompatible, and have potential for personalized therapy. Polymer able to achieve localized therapy through their unique design. First, this review compares advantages disadvantages natural synthetic polymeric materials as well describes application in UC Then, preparation, characterization methods, current challenges common polymer presented. Next, one‐by‐one examples nanoparticle‐targeted drug delivery strategies treatment In addition, nanoparticle‐based therapeutic approaches UC, including anti‐inflammatory therapies, reactive oxygen species scavenging intestinal flora modulation Finally, future research directions discussed identified. The aim paper provide valuable references guidance researchers design develop novel therapies.

Language: Английский

Citations

0