Avian Influenza – The next travel-associated pandemic? Proactive One Health surveillance is required to reduce the risk of the spread

Travel Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: unknown, P. 102829 - 102829

Published: Feb. 1, 2025

Language: Английский

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Chicken C4BPM facilitates replication of H5N1 and H9N2 Avian Influenza Viruses by inhibiting the production of type I interferons

Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104868 - 104868

Published: Jan. 31, 2025

Avian influenza viruses (AIVs) are potential pandemic of global concern, posing a major threat to both the poultry industry and human health. Host factors play key role in replication AIVs, while function complement component 4 binding protein, membrane (C4BPM) this process is still unclear. This research reports that C4BPM promotes H5N1 H9N2 AIVs by inhibiting type I interferons (IFNs). infection up-regulate expression chicken embryo fibroblast cells (DF-1). To verify knockout (C4BPM-KO) stable overexpressing (C4BPM-overexpressing) DF-1 were generated using lentivirus-mediated CRISPR/Cas9 gene editing technology molecular cloning strategies. Replication promoted C4BPM-overexpressing with inhibited IFNs (IFN-α, IFN-β), protein kinase R (PKR), cholesterol 25-hydroxylase (CH25H), interferon regulatory factor (IRF) 3, mitochondrial antiviral signaling (MAVS) compared cells. However, C4BPM-KO increased above related anti-viral factors. Further results showed did not affect viral adsorption, while, promote entry AIVs. These expand range host regulating suggest promising target for agent.

Language: Английский

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Highly Pathogenic Avian Influenza H5N1 in Cats (Felis catus): A Systematic Review and Meta-Analysis

Animals, Journal Year: 2025, Volume and Issue: 15(10), P. 1441 - 1441

Published: May 16, 2025

Introduction: Highly pathogenic avian influenza (HPAI) H5N1, a zoonotic virus primarily affecting birds, has shown increasing cross-species transmission, including to domestic animals such as cats. Recent reports of cat infections, often associated with contact infected birds or the consumption raw milk from H5N1-positive cattle, raise concerns about their role in viral adaptation and transmission. Objective: To assess global prevalence characteristics H5N1 infections cats (Felis catus) through systematic review meta-analysis. Methods: Following PRISMA guidelines, we conducted search across PubMed, Scopus, Web Science up 1 March 2025. Observational studies reporting seroprevalence were included. Data extraction quality assessment performed independently by four reviewers. Meta-analyses using random-effects model, heterogeneity was assessed via I2 statistics. Results: Twenty-one met inclusion criteria, which eight included meta-analysis (n = 3586 cats). The pooled Felis catus due 0.7% (95%CI: 0.3-1.1%), high (I2 86.5%). varied diagnostic method, region, type, time. Domestic those Africa had higher infection rates (20.0% 32.0%, respectively). Case 35) revealed mortality (74%), predominantly clade 2.3.4.4b, neurological respiratory manifestations. Conclusions: Although overall is low, increasing, particularly 2.3.4.4b. Their close humans other highlights need for enhanced surveillance, diagnostics, One Health strategies mitigate risks.

Language: Английский

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A review of the animal influenza viruses and their impact on human health

Deleted Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 26, 2025

Abstract Influenza viruses are a complex group of microorganisms that cause flu-like illnesses in humans and animals. These can multiply infect different animal hosts like the pigs, birds. Furthermore, influenza type A have potential to undergo significant genetic variations within develop into novel viral strain with high pathogenic potential. This evolution pose health risks animals humans. Therefore, it is important understand assess their narrative review discusses origin, epidemiology, transmission dynamics, impact on human treatment preventive strategies including WHOs one-health intervention, vaccination, for these transmit between possibly resulting pandemics.

Language: Английский

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The Growing Risk of Avian Influenza (H5N1) in Dairy Cows: Clinical, Economic, and Public Health Consequences

New Microbes and New Infections, Journal Year: 2024, Volume and Issue: 62, P. 101531 - 101531

Published: Nov. 13, 2024

Language: Английский

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