Persistent CD19+ B cell lymphopenia in critically ill COVID-19 patients 50 days after symptom onset DOI Creative Commons

Hui Jeong An,

Ting Li, Xinyue Zhang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 22, 2024

Introduction Long COVID (LC) poses a persistent challenge in clinical practice due to limited understanding of its etiology. LC is hypothesized stem from aberrant immune responses COVID-19. Vaccinations, which boost cells restore function, could help ease symptoms. Methods To exclude the impact vaccination, we examined cell profiles recovering COVID-19 patients before vaccines were available. White blood differentials monitored ninety-twohealthy unvaccinated controls. Seventy-six upon admission and on 50th day post-symptom onset (DPSO50). Peripheral lymphocyte subsets analyzed using flow cytometry. Results Mild cases showed no significant changes counts or DPSO50. By DPSO50, severe critical almost complete recovery lymphopenia, with having CD19+ B-cell approximately 45% lower than mild group. Severe exhibited reduced frequencies, displaying around 48% higher natural killer (NK) counts. In cases, NK negatively correlated (r=-0.528, p=0.02). Additionally, positive correlations between CD4+ T-cell (r=0.83, p<0.01), CD8+ (r=0.74, p<0.01). demonstrated decreased CD4+CD25+CD127lowFoxP3+ regulatory T-cells (Tregs), positively (r=0.37, p<0.05). Discussion Our findings indicate that change dynamically during recovery, depending disease severity. This study suggests convalescent may experience long-lasting lymphopenia.

Language: Английский

Efficacy of Vitamin D Replacement Therapy on 28 Cases of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 Vaccination DOI Creative Commons
Shohta Kodama,

Nafuko Konishi,

Yuriko Hirai

et al.

Nutrition, Journal Year: 2025, Volume and Issue: 134, P. 112718 - 112718

Published: Feb. 19, 2025

Prolonged symptoms have been reported following both COVID-19 infection and vaccination, with some cases leading to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Of 80 patients presenting our hospital postvaccination syndrome, 28 met the diagnostic criteria for ME/CFS. We conducted a retrospective study on these patients. measured serum 25-hydroxyvitamin D levels in who developed ME/CFS after vaccination between August 2022 February 2024. Vitamin replacement therapy included dietary counseling, sun exposure recommendations, oral vitamin supplementation. evaluated changes blood symptom improvement. At initial visit, 27 of diagnosed had insufficient or deficient (16 ± 4 ng/mL, mean SD). Following therapy, we observed an increase (28 5 ng/mL) associated decrease (from 10.3 2.1 3.3 2.0). Notably, 23 (82%) no longer therapy. Among symptoms, sleep problems showed most improvement (71%), followed by autonomic (68%). For developing levels, appropriate under medical guidance may lead symptomatic relief. are preparing randomized controlled trial evaluate efficacy individuals deficiency vaccination.

Language: Английский

Citations

0
Recent Debacle on COVID-19 Vaccine Front Will Fuel Vaccine Hesitancy More DOI Creative Commons

Nikunja Kumar Das,

Sahjid Mukhida,

Rajashri Patil

et al.

Journal of Marine Medical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Citations

0
Persistent CD19+ B cell lymphopenia in critically ill COVID-19 patients 50 days after symptom onset DOI Creative Commons

Hui Jeong An,

Ting Li, Xinyue Zhang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Nov. 22, 2024

Introduction Long COVID (LC) poses a persistent challenge in clinical practice due to limited understanding of its etiology. LC is hypothesized stem from aberrant immune responses COVID-19. Vaccinations, which boost cells restore function, could help ease symptoms. Methods To exclude the impact vaccination, we examined cell profiles recovering COVID-19 patients before vaccines were available. White blood differentials monitored ninety-twohealthy unvaccinated controls. Seventy-six upon admission and on 50th day post-symptom onset (DPSO50). Peripheral lymphocyte subsets analyzed using flow cytometry. Results Mild cases showed no significant changes counts or DPSO50. By DPSO50, severe critical almost complete recovery lymphopenia, with having CD19+ B-cell approximately 45% lower than mild group. Severe exhibited reduced frequencies, displaying around 48% higher natural killer (NK) counts. In cases, NK negatively correlated (r=-0.528, p=0.02). Additionally, positive correlations between CD4+ T-cell (r=0.83, p<0.01), CD8+ (r=0.74, p<0.01). demonstrated decreased CD4+CD25+CD127lowFoxP3+ regulatory T-cells (Tregs), positively (r=0.37, p<0.05). Discussion Our findings indicate that change dynamically during recovery, depending disease severity. This study suggests convalescent may experience long-lasting lymphopenia.

Language: Английский

Citations

0