Maternal and neonatal COVID-19 – the pandemic experience in a tertiary maternity unit in Romania – unicentric, prospective study DOI Open Access
Maria Livia Ognean, Dumitru Alin Teacoe, I Radu

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(1-2), P. 8 - 23

Published: June 30, 2023

Background and objectives. Multiple reports, available while the pandemic progressed, raised concerns that COVID-19 poses higher risks to pregnant women their newborns. Still, limited evidence exists on impact of during pregnancy perinatal period. This study aimed evaluate rate early-onset neonatal COVID outcomes newborns born by mothers diagnosed with at delivery concerning presence maternal symptoms dominant SARS-CoV-2 variant. Materials methods. The prospective data confirmed infection admission for was developed in a tertiary maternity hospital between February 1, 2020, December 2023. All admitted were screened infection, and, if positive, newborn also screened. Data all positive RT-PCT test extracted from medical charts electronic system hospital: pregnancy, delivery, symptoms, demographics, gestational age, birth weight, Apgar score, pathology, routine laboratory tests, results RT-PCR virus, feedings, death charts. primary neonatal: rates, prematurity, conditions. IBM SPSS 23 used analysis comparisons. Results. A total number 218 (92.7% asymptomatic) neonates included study. occurred 1.91% deliveries registered unit Neonatal 3/218 infants, none symptomatic, transmission 1.37%. Most delivered COVID-19-positive term, only 14 prematurely, 16 had weight <2500 g; 15% COVID-19-infected condition needed significant interventions or therapies. mean age score 1 minute significantly lower infants symptomatic Delta/Omicron/other new variants period as compared those asymptomatic pre-Delta period, respectively. Also, major minor conditions found more often (p<0.050) (p<0.050). Conclusions. Our low rates COVID-19. we have prematurity LBW, maternal-neonatal SARSCoV-2, excellent among mothers, although complications frequent Delta/Omicron/ other More studies are completely reveal virus fetal, neonatal, infant, child growth, health, development.

Language: Английский

Epigenetics of prenatal stress in humans: the current research landscape DOI Creative Commons
Linda Dieckmann, Darina Czamara

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 2, 2024

Abstract Fetal exposure to prenatal stress can have significant consequences on short- and long-term health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible process how these adverse environmental events could be biologically embedded. We evaluated candidate gene as well epigenome-wide association studies associating DNAm changes in peripheral tissues; however, most of findings lack robust replication. Prenatal stress-associated epigenetic also been linked child health including internalizing problems, neurobehavioral outcomes reactivity. Future should focus refined measurement definition its timing, ideally incorporating genomic longitudinal information. This will provide further opportunities enhance our understanding the biological embedding exposure.

Language: Английский

Citations

14
Blood DNA methylation in post-acute sequelae of COVID-19 (PASC): a prospective cohort study DOI Creative Commons
Joseph Balnis, Andy Madrid, Lisa A. Drake

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 106, P. 105251 - 105251

Published: July 17, 2024

Language: Английский

Citations

5
1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit DOI Open Access
Jozef Nahálka

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4440 - 4440

Published: April 18, 2024

The COVID-19 pandemic prompted rapid research on SARS-CoV-2 pathogenicity. Consequently, new data can be used to advance the molecular understanding of infection. present bioinformatics study discusses "spikeopathy" at level and focuses possible post-transcriptional regulation spike protein S1 subunit in host cell/tissue. A theoretical protein-RNA recognition code was check compatibility with mRNAs human transcriptome (1-L transcription). principle for this method is elucidated defined RNA binding GEMIN5 (gem nuclear organelle-associated 5) RNU2-1 (U2 spliceosomal RNA). Using described here, it shown that 45% genes/proteins identified by 1-L transcription are directly linked COVID-19, 39% indirectly 16% cannot currently associated COVID-19. stroke, diabetes, cardiac injury.

Language: Английский

Citations

1
Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study DOI Creative Commons
Anna Suleri, Kristina Salontaji, Mannan Luo

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 121, P. 244 - 256

Published: July 29, 2024

Infections during pregnancy have been robustly associated with adverse mental and physical health outcomes in offspring, yet the underlying molecular pathways remain largely unknown. Here, we examined whether exposure to common infections utero associates DNA methylation (DNAm) patterns at birth this turn relates offspring general population. Using data from 2,367 children Dutch population-based Generation R Study, first performed an epigenome-wide association study identify differentially methylated sites regions prenatal infection exposure. We also influence of timing by using self-reported cumulative scores for each trimester. Second, sought develop aggregate profile score (MPS) based on cord blood DNAm as epigenetic proxy tested MPS prospectively outcomes, including psychiatric symptoms, BMI, asthma ages 13–16 years. Third, investigated age acceleration – a marker biological aging. Across all analysis steps, our findings replicate 864 participants independent cohort (ALSPAC, UK). observed no or relation exposure, after multiple testing correction. 33 showed suggestive associations (p < 5e10 − 5; which one was nominally ALSPAC), indicating potential links genes immune, neurodevelopmental, cardiovascular pathways. While maternal reports internal hold out sample Study (R2incremental = 0.049), it did not ALSPAC 0.001), associate either cohort. Moreover, between across cohorts clocks. In contrast prior studies, reported differences exposed severe utero, do find evidence clinically evident aging within pediatric Future studies are needed establish exist but too subtle be statistically meaningful present sizes, they more similar discovery cohort, occur different tissues than blood, other may relevant mediating effect downstream outcomes.

Language: Английский

Citations

0
The COVID-19 legacy: consequences for the human DNA methylome and therapeutic perspectives DOI Creative Commons
Carlo Gaetano, Sandra Atlante, Michela Gottardi Zamperla

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract The COVID-19 pandemic has left a lasting legacy on human health, extending beyond the acute phase of infection. This article explores evidence suggesting that SARS-CoV-2 infection can induce persistent epigenetic modifications, particularly in DNA methylation patterns, with potential long-term consequences for individuals’ health and aging trajectories. review discusses methylation-based biomarkers, such as clocks, to identify individuals at risk accelerated tailor personalized interventions. Integrating clock analysis into clinical management could mark new era treatment COVID-19, possibly helping clinicians understand patient susceptibility severe outcomes establish preventive strategies. Several valuable reviews address role epigenetics infectious diseases, including Sars-CoV-2 However, this provides an original overview current understanding dimensions offering insights implications pandemic. While acknowledging limitations data, we emphasize need future research unravel precise mechanisms underlying COVID-19-induced changes explore approaches target these modifications. Graphical Abstract: Impact landscape individual response Following infection, may develop either normal immune or aberrant one, cytokine storm. Both scenarios result long-lasting consequences, known “long COVID.” condition reshape by altering contributing “epigenetic drift.” drift, further influenced various factors, lead gene expression, functionality, disease susceptibility. One significant consequence drift is acceleration biological aging, which profoundly impact medical Created BioRender.com.

Language: Английский

Citations

0
Clinical Perspectives on Maternal Immune Activation Theory DOI
Tomomi Kotani, Kazuya Fuma, Takafumi Ushida

et al.

Integrated science, Journal Year: 2024, Volume and Issue: unknown, P. 201 - 230

Published: Jan. 1, 2024

Language: Английский

Citations

0
Maternal and neonatal COVID-19 – the pandemic experience in a tertiary maternity unit in Romania – unicentric, prospective study DOI Open Access
Maria Livia Ognean, Dumitru Alin Teacoe, I Radu

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(1-2), P. 8 - 23

Published: June 30, 2023

Background and objectives. Multiple reports, available while the pandemic progressed, raised concerns that COVID-19 poses higher risks to pregnant women their newborns. Still, limited evidence exists on impact of during pregnancy perinatal period. This study aimed evaluate rate early-onset neonatal COVID outcomes newborns born by mothers diagnosed with at delivery concerning presence maternal symptoms dominant SARS-CoV-2 variant. Materials methods. The prospective data confirmed infection admission for was developed in a tertiary maternity hospital between February 1, 2020, December 2023. All admitted were screened infection, and, if positive, newborn also screened. Data all positive RT-PCT test extracted from medical charts electronic system hospital: pregnancy, delivery, symptoms, demographics, gestational age, birth weight, Apgar score, pathology, routine laboratory tests, results RT-PCR virus, feedings, death charts. primary neonatal: rates, prematurity, conditions. IBM SPSS 23 used analysis comparisons. Results. A total number 218 (92.7% asymptomatic) neonates included study. occurred 1.91% deliveries registered unit Neonatal 3/218 infants, none symptomatic, transmission 1.37%. Most delivered COVID-19-positive term, only 14 prematurely, 16 had weight <2500 g; 15% COVID-19-infected condition needed significant interventions or therapies. mean age score 1 minute significantly lower infants symptomatic Delta/Omicron/other new variants period as compared those asymptomatic pre-Delta period, respectively. Also, major minor conditions found more often (p<0.050) (p<0.050). Conclusions. Our low rates COVID-19. we have prematurity LBW, maternal-neonatal SARSCoV-2, excellent among mothers, although complications frequent Delta/Omicron/ other More studies are completely reveal virus fetal, neonatal, infant, child growth, health, development.

Language: Английский

Citations

0