Diagnosis and Classification of Follicular Lymphoma and Related Entities

Advances in Anatomic Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Follicular lymphoma (FL) is a mature B cell neoplasm classically characterized by cells harboring the t(14;18) IGH::BCL2 leading to overexpression of BCL2 in most cases. Conventional FL occurs lymph nodes and typically shows follicular B-cell proliferation expressing at least one germinal center marker. Two early lesions closely related conventional are recognized as variants, namely situ neoplasia (ISFN), duodenal-type (DTFL). lacking rearrangement ( -R negative) accounts for around 10% 15% FLs constitutes heterogeneous group FLs. Most these alternative forms considered distinct entities separate from 2022 International Consensus Classification. This review aims summarize key pathologic diagnostic features its well further emphasize increasing role molecular studies work-up.

Language: Английский

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The role of non-malignant B cells in malignant hematologic diseases

Hematology, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 18, 2025

The tumor microenvironment (TME) represents a heterogeneous, complicated ecosystem characterized by intricate interactions between cells and immune cells. During the past decade, especially T were found to play an important role in progression of many related checkpoints drugs created. In recent years, more scientists revealed critical B-cells within TME, particularly various populations non-malignant B Some studies indicated that may exert 'double-edged sword' solid tumors. However, there has been comparatively less focus on hematologic malignancies. this review, we development summarized its functions antitumor immunity with emphasis elucidating roles potential mechanisms diseases including classical Hodgkin's lymphoma, non-Hodgkin's B-cell T-cell leukemia multiple myeloma.

Language: Английский

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A low lymphocyte‐to‐monocyte ratio is independently associated with early relapse (POD24) in high tumour burden follicular lymphoma: A RELEVANCE subanalysis

British Journal of Haematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Summary The peripheral blood lymphocyte‐to‐monocyte ratio (LMR) has been shown to predict outcomes in follicular lymphoma (FL). Among 1018 patients from the RELEVANCE trial (for previously untreated, high tumour burden FL), median LMR was 2.5 (range, 0.3–93.5) and an cut‐off of 2 mostly associated with survival end‐points. Patients ≤2 ( n = 372; 37%) were older had higher risk disease. An a shorter progression‐free (PFS) (hazard [HR] 1.39, p 0.002) overall (OS) (HR 1.44, 0.049). association PFS significant rituximab plus chemotherapy arm 0.01) inconclusive lenalidomide 0.08). Within three Follicular Lymphoma International Prognostic Index categories, retained its only low‐risk group 0.03). also progression disease within 24 months treatment initiation (univariable odds (OR) 1.84, < 0.001; multivariable OR 1.58, 0.02). In conclusion, is easily accessible parameter informative FL need treatment, being especially helpful otherwise patients. Whether incorporation immunomodulators such as will reduce negative prognostic value needs be further investigated.

Language: Английский

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Integrated analysis reveals an immune evasion prognostic signature for predicting the overall survival in patients with hepatocellular carcinoma

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 18, 2025

The development of immunotherapy has enriched the treatment hepatocellular carcinoma (HCC), but efficacy is not as expected, which may be due to immune evasion. Immune evasion related microenvironment HCC, there little research on it. We employed unsupervised clustering analysis categorize patients from TCGA based 182 evasion-related genes (IEGs). utilized single-sample gene set enrichment (ssGSEA) and CIBERSORT calculate differences in cell infiltration between clusters. cells immune-related pathways were assessed using GSEA. constructed an escape prognosis signature (IEPS) univariate Cox LASSO algorithms evaluated predictive performance IEPS with receiver operating characteristic (ROC) curves survival curves. Additionally, we established a nomogram for clinical application IEPS. IHC validated expression Carbamoyl phosphate synthetase 2, Aspartate transcarbamylase, Dihydroorotase (CAD) Phosphatidylinositol Glycan Anchor Biosynthesis Class U (PIGU) HCC. transfected liver cancer lines siRNA overexpression plasmids, confirmed relationship CAD, PIGU, potential downstream TGF-β1 HCC qRT-PCR Western blot. Finally, tumor response CAD animal model. Unsupervised IEGs divided into two groups. There significant characteristics groups patients. Scoring revealed that higher scores associated poorer overall (OS). Validation was performed ICGC database. TIME indicated high-IEPS group immunosuppressive state, possibly increase Treg infiltration. Compared normal cells, expressed levels PIGU. Cellular experimental results showed positive correlation PIGU expression. Animal experiments demonstrated significantly promoted progression, strong prognostic value patients, provide perspectives new biomarkers therapeutic targets

Language: Английский

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Perspective on Immunoglobulin N-Glycosylation Status in Follicular Lymphoma: Uncovering BCR-Dependent and Independent Mechanisms Driving Subclonal Evolution

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1219 - 1219

Published: April 4, 2025

Follicular lymphoma (FL) is a heterogeneous and incurable disease. One of the hallmark features FL cells introduction N-glycosylation (N-gly) amino acid sequence motifs into immunoglobulin variable (IgV) region through ongoing somatic hypermutation (SHM) in early stages development. These N-gly motifs, containing oligomannoses, are rarely found healthy B but evidently play crucial role clonal evolution survival hostile environment germinal centers. The random nature SHM occasionally results loss productive (Ig) genes or elimination genes. Such events typically lead to deletion, as demonstrated by longitudinal analysis samples. However, rare N-gly-negative subclones demonstrate prolonged with evidence SHM, giving rise new before eventual deletion. This observation suggests presence specific mechanisms supporting their proliferation. perspective examines current literature explores whether detailed transcriptomic functional comparison characterized different statuses, particular focus on subclones, will comprehensive understanding both N-gly-dependent independent pro-survival proliferative transcriptional signatures. Specifically, it aims deepen our pathobiology identify novel therapeutic targets for better disease management.

Language: Английский

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PDL1-expressing macrophages infiltrate diffuse large B-cell lymphoma and promote lymphoma growth in a MYC-driven experimental model

Blood Cancer Journal, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

Language: Английский

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The essential microenvironmental role of oligomannoses specifically inserted into the antigen-binding sites of lymphoma cells

Blood, Journal Year: 2023, Volume and Issue: 143(12), P. 1091 - 1100

Published: Nov. 22, 2023

Language: Английский

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Identification and Functional Investigation of Hub Genes Associated with Follicular Lymphoma

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: May 27, 2024

Language: Английский

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Intratumoral T-cell composition predicts epcoritamab-based treatment efficacy in B-cell non-Hodgkin lymphomas

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 5, 2024

Leveraging endogenous tumor-resident T-cells for immunotherapy using bispecific antibodies (BsAb) targeting CD20 and CD3 has emerged as a promising therapeutic strategy patients with B-cell non-Hodgkin lymphomas. However, features associated treatment response or resistance are unknown. To this end, we analyzed data from treated epcoritamab-containing regimens in the EPCORE NHL-2 trial (NCT04663347). We observed downregulation of expression on B-cells following initiation both progressing achieving durable complete responses (CR), suggesting that does not universally predict to BsAb-based therapy. Single-cell immune profiling tumor biopsies obtained one cycle therapy revealed substantial clonal expansion cytotoxic CD4+ CD8+ CR, an follicular helper regulatory whose disease progressed. These results identify distinct T-cell profiles BsAb

Language: Английский

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Impact of positive CD4 cells on event‐free survival in follicular lymphoma patients

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(17)

Published: Sept. 1, 2024

Abstract Objective Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial. Methods Immunohistochemistry was used to examine expression positive CD4 103 patients with FL 1‐3A. Early failure described as failing achieve event‐free survival (EFS) at 12 or 24 months. Results There were 49 (47.6%) male and 54 (52.4%) females, a median age years. Compared <20% cells, ≥20% exhibited significant lower risk early (2‐year EFS rate: 56.7% vs 73.5%, p = 0.047). When stratified based on cell combined FLIPI, the ( 0.002) OS 0.007) significantly different. Conclusions This study demonstrated that higher predicts lymphoma, combination analysis FLIPI could better predict disease relapse outcome.

Language: Английский

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