Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 27, 2025

Background UCK2 (Uridine-Cytidine Kinase 2) is a promising prognostic marker for malignant tumors, but its association with immune infiltration and cancer stemness in pan-cancer remains to be fully understood. we find that gene closed related RNA scores (RNAss) DNA (DNAss), which measured the tumor stemness. We also discover an between expression cells by CIBERSORT algorithm, ESTIMATE algorithm ssGSEA especially, T cell, monocytes, mast cells, macrophages. This study aims shed light on role possible mechanism of pan-cancer. Methods used R programming language bulk sequencing data analysis, were obtained from University California, Santa Cruz (UCSC) datasets. UCSC database very useful explore TCGA other genomics datasets, The explored at transcriptome level came database. differential normal samples. Immunohistochemistry (IHC) was utilized validate different types cancers using tissue chips. correlations prognosis, genetic instability, repair, stem cell characteristics, investigated. Furthermore, single-cell acquired Gene Expression Omnibus (GEO) database, relationship cells. GEO famous public supporting freely disseminates microarray data. Finally, analyzed correlation drug sensitivity. Results observed high most remarkably prognosis pan-cancers. found increased associated higher instability. Additionally, positive relationships mismatch repair genes, homologous recombination across types. There significant Moreover, as expected, checkpoint human leucocyte antigen (HLA) negatively UCK2. Similarly, have negative major histocompatibility complex (MHC) genes. noted had sensitivity various anti-cancer drug. Conclusion plays pivotal roles immunity, it exhibits strong checkpoints HLA. highlights potential impact

Language: Английский

SYNLAC Prime probiotics alleviate Enterocytozoon hepatopenaei-induced damage in white shrimp, Penaeus vannamei by enhancing growth, immunity, and resistance to Vibrio parahaemolyticus

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110383 - 110383

Published: April 1, 2025

Language: Английский

Viral oncogenesis in cancer: from mechanisms to therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: May 11, 2025

Abstract The year 2024 marks the 60th anniversary of discovery Epstein-Barr virus (EBV), first confirmed to cause human cancer. Viral infections significantly contribute global cancer burden, with seven known Group 1 oncogenic viruses, including hepatitis B (HBV), papillomavirus (HPV), EBV, Kaposi sarcoma-associated herpesvirus (KSHV), C (HCV), T-cell leukemia type (HTLV-1), and immunodeficiency (HIV). These viruses induce cellular transformation development by altering various biological processes within host cells, particularly under immunosuppression or co-carcinogenic exposures. are primarily associated hepatocellular carcinoma, gastric cancer, cervical nasopharyngeal sarcoma, lymphoma, adult leukemia/lymphoma. Understanding mechanisms viral oncogenesis is crucial for identifying characterizing early virus-related cancers, providing new targets strategies treatment prevention. This review outlines epidemiology tumors, milestone events in research, process which infect target cells. It then focuses on molecular these tumors directly indirectly, regulation oncogenes tumor suppressor genes, induction genomic instability, disruption regular life cycle immune suppression, chronic inflammation, inducing angiogenesis. Finally, current therapeutic recent advances preclinical clinical research discussed.

Language: Английский