Molecules,
Journal Year:
2018,
Volume and Issue:
23(3), P. 518 - 518
Published: Feb. 26, 2018
Melatonin
is
a
natural
indoleamine
produced
by
the
pineal
gland
that
has
many
functions,
including
regulation
of
circadian
rhythm.
Many
studies
have
reported
anticancer
effect
melatonin
against
myriad
cancer
types.
Cancer
hallmarks
include
sustained
proliferation,
evading
growth
suppressors,
metastasis,
replicative
immortality,
angiogenesis,
resisting
cell
death,
altered
cellular
energetics,
and
immune
evasion.
activity
mediated
interfering
with
various
hallmarks.
This
review
summarizes
role
in
each
hallmark.
The
discussed
this
should
serve
as
solid
foundation
for
researchers
physicians
to
support
basic
clinical
on
promising
agent.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(6), P. 1960 - 1960
Published: March 13, 2020
Cyclin-dependent
kinases
(CDKs)
are
serine/threonine
whose
catalytic
activities
regulated
by
interactions
with
cyclins
and
CDK
inhibitors
(CKIs).
CDKs
key
regulatory
enzymes
involved
in
cell
proliferation
through
regulating
cell-cycle
checkpoints
transcriptional
events
response
to
extracellular
intracellular
signals.
Not
surprisingly,
the
dysregulation
of
is
a
hallmark
cancers,
inhibition
specific
members
considered
an
attractive
target
cancer
therapy.
In
breast
(BC),
dual
CDK4/6
inhibitors,
palbociclib,
ribociclib,
abemaciclib,
combined
other
agents,
were
approved
Food
Drug
Administration
(FDA)
recently
for
treatment
hormone
receptor
positive
(HR+)
advanced
or
metastatic
(A/MBC),
as
well
sub-types
cancer.
Furthermore,
ongoing
studies
identified
more
selective
promising
clinical
targets.
this
review,
we
focus
on
roles
driving
progression,
checkpoints,
regulation,
highlight
dysregulated
activation
BC.
We
also
discuss
most
relevant
currently
BC
trials,
special
emphasis
used
estrogen
receptor-positive
(ER+)/human
epidermal
growth
factor
2-negative
(HER2−)
M/ABC
patients,
emerging
precise
therapeutic
strategies,
such
combination
therapies
microRNA
(miRNA)
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2013,
Volume and Issue:
5(3), P. a008904 - a008904
Published: March 1, 2013
Robert
J.
Duronio1,2,3
and
Yue
Xiong2,3,4
1Department
of
Biology
Genetics,
University
North
Carolina,
Chapel
Hill,
Carolina
27599
2Program
in
Molecular
Biotechnology,
3Lineberger
Comprehensive
Cancer
Center,
4Department
Biochemistry
Biophysics,
Correspondence:
duronio{at}med.unc.edu;
yxiong{at}email.unc.edu
Critical Reviews in Biochemistry and Molecular Biology,
Journal Year:
2013,
Volume and Issue:
48(6), P. 575 - 608
Published: Oct. 3, 2013
The
Mediator
complex
is
a
multi-subunit
assembly
that
appears
to
be
required
for
regulating
expression
of
most
RNA
polymerase
II
(pol
II)
transcripts,
which
include
protein-coding
and
non-coding
genes.
pol
function
within
the
pre-initiation
(PIC),
consists
Mediator,
II,
TFIIA,
TFIIB,
TFIID,
TFIIE,
TFIIF
TFIIH
approximately
4.0
MDa
in
size.
serves
as
central
scaffold
PIC
helps
regulate
activity
ways
remain
poorly
understood.
also
generally
targeted
by
sequence-specific,
DNA-binding
transcription
factors
(TFs)
work
control
gene
programs
response
developmental
or
environmental
cues.
At
basic
level,
functions
relaying
signals
from
TFs
directly
enzyme,
thereby
facilitating
TF-dependent
regulation
expression.
Thus,
essential
converting
biological
inputs
(communicated
TFs)
physiological
responses
(via
changes
expression).
In
this
review,
we
summarize
an
expansive
body
research
on
complex,
with
emphasis
yeast
mammalian
complexes.
We
focus
basics
underlie
function,
such
its
structure
subunit
composition,
describe
broad
regulatory
influence
expression,
ranging
chromatin
architecture
initiation
elongation,
mRNA
processing.
activity,
including
TFs,
RNAs
CDK8
module.
