Molecules,
Journal Year:
2018,
Volume and Issue:
23(3), P. 518 - 518
Published: Feb. 26, 2018
Melatonin
is
a
natural
indoleamine
produced
by
the
pineal
gland
that
has
many
functions,
including
regulation
of
circadian
rhythm.
Many
studies
have
reported
anticancer
effect
melatonin
against
myriad
cancer
types.
Cancer
hallmarks
include
sustained
proliferation,
evading
growth
suppressors,
metastasis,
replicative
immortality,
angiogenesis,
resisting
cell
death,
altered
cellular
energetics,
and
immune
evasion.
activity
mediated
interfering
with
various
hallmarks.
This
review
summarizes
role
in
each
hallmark.
The
discussed
this
should
serve
as
solid
foundation
for
researchers
physicians
to
support
basic
clinical
on
promising
agent.
Cancer Discovery,
Journal Year:
2020,
Volume and Issue:
10(3), P. 351 - 370
Published: Feb. 18, 2020
Drugs
targeting
the
cell
cycle-regulatory
cyclin-dependent
kinase
(CDK)
4
and
6
have
been
approved
for
treatment
of
hormone
receptor-positive
breast
cancer,
inhibitors
other
cell-cycle
CDKs
are
currently
in
clinical
trials.
Another
class
CDKs,
transcription-associated
including
CDK7,
CDK8,
CDK9,
CDK12
CDK13,
critical
regulators
gene
expression.
Recent
evidence
suggests
several
novel
functions
these
regulation
epigenetic
modifications,
intronic
polyadenylation,
DNA-damage
responses,
genomic
stability.
Here,
we
summarize
our
current
understanding
transcriptional
their
utility
as
biomarkers,
potential
therapeutic
targets.
SIGNIFICANCE:
CDK
CDK4
CDK6
Several
studies
now
point
to
opportunities
by
inhibiting
well
vulnerabilities
with
PARP
immunotherapy
tumors
deficient
CDKs.
Journal of Clinical and Experimental Hepatology,
Journal Year:
2019,
Volume and Issue:
9(2), P. 221 - 232
Published: Jan. 27, 2019
Hepatocellular
carcinoma
(HCC)
is
swiftly
increasing
in
prevalence
globally
with
a
high
mortality
rate.
The
progression
of
HCC
patients
induced
advanced
fibrosis,
mainly
cirrhosis,
and
hepatitis.
absence
proper
preventive
or
curative
treatment
methods
encouraged
extensive
research
against
to
develop
new
therapeutic
strategies.
Food
Drug
Administration-approved
Nexavar
(sorafenib)
used
the
unresectable
HCC.
In
2017,
Stivarga
(regorafenib)
Opdivo
(nivolumab)
got
approved
for
after
being
treated
sorafenib,
2018,
Lenvima
(lenvatinib)
But,
owing
rapid
drug
resistance
development
toxicities,
these
options
are
not
completely
satisfactory.
Therefore,
there
an
urgent
need
systemic
combination
therapies
that
target
different
signaling
mechanisms,
thereby
decreasing
prospect
cancer
cells
developing
treatment.
this
review,
etiology
strategies
include
currently
drugs
other
potential
candidates
such
as
Milciclib,
palbociclib,
galunisertib,
ipafricept,
ramucirumab
evaluated.
Open Biology,
Journal Year:
2018,
Volume and Issue:
8(9)
Published: Sept. 1, 2018
Since
their
characterization
as
conserved
modules
that
regulate
progression
through
the
eukaryotic
cell
cycle,
cyclin-dependent
protein
kinases
(CDKs)
in
higher
cells
are
now
also
emerging
significant
regulators
of
transcription,
metabolism
and
differentiation.
The
cyclins,
though
originally
characterized
CDK
partners,
have
CDK-independent
roles
include
regulation
DNA
damage
repair
transcriptional
programmes
direct
differentiation,
apoptosis
metabolic
flux.
This
review
compares
structures
members
cyclin
families
determined
by
X-ray
crystallography,
considers
what
mechanistic
insights
they
provide
to
guide
functional
studies
distinguish
CDK-
cyclin-specific
activities.
Aberrant
activity
is
a
hallmark
number
diseases,
structural
can
important
identify
novel
routes
therapy.
Annual Review of Plant Biology,
Journal Year:
2015,
Volume and Issue:
67(1), P. 439 - 462
Published: Dec. 9, 2015
Because
the
genome
stores
all
genetic
information
required
for
growth
and
development,
it
is
of
pivotal
importance
to
maintain
DNA
integrity,
especially
during
cell
division,
when
prone
replication
errors
damage.
Although
over
last
two
decades
has
become
evident
that
basic
cycle
toolbox
plants
shares
several
similarities
with
those
fungi
mammals,
appear
have
evolved
a
set
distinct
checkpoint
regulators
in
response
different
types
stress.
This
might
be
consequence
plants'
sessile
lifestyle,
which
exposes
them
unique
damage-inducing
conditions.
In
this
review,
we
highlight
stress
typically
experience
describe
plant-specific
molecular
mechanisms
control
division
these
stresses.
